High efficacy with deep nurse-administered propofol sedation for advanced gastroenterologic endoscopic procedures
Background and study aims: Whereas data on moderate nurse-administered propofol sedation (NAPS) efficacy and safety for standard endoscopy is abundant, few reports on the use of deep sedation by endoscopy nurses during advanced endoscopy, such as Endoscopic Retrograde Cholangiopancreatography (ERCP)...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2016-01-01
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| Series: | Endoscopy International Open |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-107899 |
| _version_ | 1819047892103462912 |
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| author | Jeppe Thue Jensen Pernille Hornslet Lars Konge Ann Merete Møller Peter Vilmann |
| author_facet | Jeppe Thue Jensen Pernille Hornslet Lars Konge Ann Merete Møller Peter Vilmann |
| author_sort | Jeppe Thue Jensen |
| collection | DOAJ |
| description | Background and study aims: Whereas data on moderate nurse-administered propofol sedation (NAPS) efficacy and safety for standard endoscopy is abundant, few reports on the use of deep sedation by endoscopy nurses during advanced endoscopy, such as Endoscopic Retrograde Cholangiopancreatography (ERCP) and Endoscopic Ultrasound (EUS) are available and potential benefits or hazards remain unclear. The aims of this study were to investigate the efficacy of intermittent deep sedation with propofol for a large cohort of advanced endoscopies and to provide data on the safety.
Patients and methods: All available data from patients sedated with intermittent deep NAPS for ERCP, EUS or double balloon enteroscopy (DBE, since the method was implemented in May 2007 through December 2012 were included for evaluation in a retrospective case-control design.
Results: Data from 1899 patients undergoing 1899 procedures were included for evaluation. All but one procedure were completed with intermittent deep NAPS. The mean propofol dose was 397 mg (SD: 232.4) and the infusion rate was 23.9 mg/kg. The frequency of hypoxia was 4.3 % and 20 patients needed assisted ventilation (1.1 %). Anesthesiologic support was requested eight times (0.4 %). One patient was intubated due to suspected aspiration.
Conclusions: Intermittent deep NAPS for advanced endoscopies in selected patients provided an almost 100 % success rate. However, the rate of hypoxia, hypotension and respiratory support was high compared with previously published data, but the method was still assessed as safe. |
| first_indexed | 2024-12-21T11:07:34Z |
| format | Article |
| id | doaj.art-bd859d927edd4009975d551e681397e1 |
| institution | Directory Open Access Journal |
| issn | 2364-3722 2196-9736 |
| language | English |
| last_indexed | 2024-12-21T11:07:34Z |
| publishDate | 2016-01-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Endoscopy International Open |
| spelling | doaj.art-bd859d927edd4009975d551e681397e12022-12-21T19:06:11ZengGeorg Thieme Verlag KGEndoscopy International Open2364-37222196-97362016-01-010401E107E11110.1055/s-0041-107899High efficacy with deep nurse-administered propofol sedation for advanced gastroenterologic endoscopic proceduresJeppe Thue Jensen0Pernille Hornslet1Lars Konge2Ann Merete Møller3Peter Vilmann4Gastro unit D, Department of endoscopy, Copenhagen University Hospital Herlev, DenmarkGastro unit D, Department of endoscopy, Copenhagen University Hospital Herlev, DenmarkCopenhagen Academy for Medical Education and Simulation, University of Copenhagen and the Capital Region of Denmark, DenmarkDepartment of Anaesthesiology, Copenhagen University Hospital Herlev, DenmarkGastro unit D, Department of endoscopy, Copenhagen University Hospital Herlev, DenmarkBackground and study aims: Whereas data on moderate nurse-administered propofol sedation (NAPS) efficacy and safety for standard endoscopy is abundant, few reports on the use of deep sedation by endoscopy nurses during advanced endoscopy, such as Endoscopic Retrograde Cholangiopancreatography (ERCP) and Endoscopic Ultrasound (EUS) are available and potential benefits or hazards remain unclear. The aims of this study were to investigate the efficacy of intermittent deep sedation with propofol for a large cohort of advanced endoscopies and to provide data on the safety. Patients and methods: All available data from patients sedated with intermittent deep NAPS for ERCP, EUS or double balloon enteroscopy (DBE, since the method was implemented in May 2007 through December 2012 were included for evaluation in a retrospective case-control design. Results: Data from 1899 patients undergoing 1899 procedures were included for evaluation. All but one procedure were completed with intermittent deep NAPS. The mean propofol dose was 397 mg (SD: 232.4) and the infusion rate was 23.9 mg/kg. The frequency of hypoxia was 4.3 % and 20 patients needed assisted ventilation (1.1 %). Anesthesiologic support was requested eight times (0.4 %). One patient was intubated due to suspected aspiration. Conclusions: Intermittent deep NAPS for advanced endoscopies in selected patients provided an almost 100 % success rate. However, the rate of hypoxia, hypotension and respiratory support was high compared with previously published data, but the method was still assessed as safe.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-107899 |
| spellingShingle | Jeppe Thue Jensen Pernille Hornslet Lars Konge Ann Merete Møller Peter Vilmann High efficacy with deep nurse-administered propofol sedation for advanced gastroenterologic endoscopic procedures Endoscopy International Open |
| title | High efficacy with deep nurse-administered propofol sedation for advanced gastroenterologic endoscopic procedures |
| title_full | High efficacy with deep nurse-administered propofol sedation for advanced gastroenterologic endoscopic procedures |
| title_fullStr | High efficacy with deep nurse-administered propofol sedation for advanced gastroenterologic endoscopic procedures |
| title_full_unstemmed | High efficacy with deep nurse-administered propofol sedation for advanced gastroenterologic endoscopic procedures |
| title_short | High efficacy with deep nurse-administered propofol sedation for advanced gastroenterologic endoscopic procedures |
| title_sort | high efficacy with deep nurse administered propofol sedation for advanced gastroenterologic endoscopic procedures |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-107899 |
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