Highly expressed FAM189B predicts poor prognosis in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most malignant tumors with persistently high morbidity and mortality. However, the expression, prognostic and clinical significance of FAM189 family genes in HCC remain largely unknown. In this study, the expression levels of FAM189 family genes in HCC we...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Pathology and Oncology Research |
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| Online Access: | https://www.por-journal.com/articles/10.3389/pore.2022.1610674/full |
| _version_ | 1827290287704113152 |
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| author | Wanshan Ma Xiaoning Zhang Chenchen Ma Peng Liu |
| author_facet | Wanshan Ma Xiaoning Zhang Chenchen Ma Peng Liu |
| author_sort | Wanshan Ma |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is one of the most malignant tumors with persistently high morbidity and mortality. However, the expression, prognostic and clinical significance of FAM189 family genes in HCC remain largely unknown. In this study, the expression levels of FAM189 family genes in HCC were analyzed through TCGA-LIHC and ICGC-LIRI-JP cohorts, and further validated in multiple independent GEO datasets. It was found that the expression of FAM189B was significantly upregulated in HCC tumor tissues, while the expression of FAM189A1 and FAM189A2 was not significantly changed between tumor and adjacent tissues. Further analysis revealed that upregulated copy number variation contributed to increased expression of FAM189B in HCC. Survival analysis showed that highly expressed FAM189B was significantly correlated with unfavorable prognosis, including overall survival, disease-specific survival, and progression-free interval. Univariate and multivariate Cox regression analysis showed that FAM189B was a potential novel prognosis factor for HCC patients. In addition, the association between FAM189B expression and clinical and molecular characteristics was analyzed. High expression of FAM189B was associated with high AFP level, high predicted risk metastasis signature, and TP53 mutation, while there was no significant association between FAM189B expression and cancer stage or tumor grade of HCC. Gene set enrichment analysis revealed that highly expressed FAM189B was closely related with signal pathways and biological processes associated with cell proliferation and cell cycle in HCC. In conclusion, this study suggested that FAM189B was highly expressed in HCC and highly expressed FAM189B may serve as an effective prognostic indicator and a potential therapeutic target for HCC patients. |
| first_indexed | 2024-04-24T12:13:57Z |
| format | Article |
| id | doaj.art-bd85a5e2e4254b0ba4e03d408c889551 |
| institution | Directory Open Access Journal |
| issn | 1532-2807 |
| language | English |
| last_indexed | 2024-04-24T12:13:57Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Pathology and Oncology Research |
| spelling | doaj.art-bd85a5e2e4254b0ba4e03d408c8895512024-04-08T09:32:17ZengFrontiers Media S.A.Pathology and Oncology Research1532-28072022-11-012810.3389/pore.2022.16106741610674Highly expressed FAM189B predicts poor prognosis in hepatocellular carcinomaWanshan Ma0Xiaoning Zhang1Chenchen Ma2Peng Liu3Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Laboratory Medicine, Jinan, Shandong, ChinaDepartment of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Laboratory Medicine, Jinan, Shandong, ChinaCentral Laboratory, Affiliated Hospital of Shandong University of Chinese Traditional Medicine, Jinan, Shandong, ChinaDepartment of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Laboratory Medicine, Jinan, Shandong, ChinaHepatocellular carcinoma (HCC) is one of the most malignant tumors with persistently high morbidity and mortality. However, the expression, prognostic and clinical significance of FAM189 family genes in HCC remain largely unknown. In this study, the expression levels of FAM189 family genes in HCC were analyzed through TCGA-LIHC and ICGC-LIRI-JP cohorts, and further validated in multiple independent GEO datasets. It was found that the expression of FAM189B was significantly upregulated in HCC tumor tissues, while the expression of FAM189A1 and FAM189A2 was not significantly changed between tumor and adjacent tissues. Further analysis revealed that upregulated copy number variation contributed to increased expression of FAM189B in HCC. Survival analysis showed that highly expressed FAM189B was significantly correlated with unfavorable prognosis, including overall survival, disease-specific survival, and progression-free interval. Univariate and multivariate Cox regression analysis showed that FAM189B was a potential novel prognosis factor for HCC patients. In addition, the association between FAM189B expression and clinical and molecular characteristics was analyzed. High expression of FAM189B was associated with high AFP level, high predicted risk metastasis signature, and TP53 mutation, while there was no significant association between FAM189B expression and cancer stage or tumor grade of HCC. Gene set enrichment analysis revealed that highly expressed FAM189B was closely related with signal pathways and biological processes associated with cell proliferation and cell cycle in HCC. In conclusion, this study suggested that FAM189B was highly expressed in HCC and highly expressed FAM189B may serve as an effective prognostic indicator and a potential therapeutic target for HCC patients.https://www.por-journal.com/articles/10.3389/pore.2022.1610674/fullbiomarkerprognosishepatocellular carcinomaclinical significanceFAM189B |
| spellingShingle | Wanshan Ma Xiaoning Zhang Chenchen Ma Peng Liu Highly expressed FAM189B predicts poor prognosis in hepatocellular carcinoma Pathology and Oncology Research biomarker prognosis hepatocellular carcinoma clinical significance FAM189B |
| title | Highly expressed FAM189B predicts poor prognosis in hepatocellular carcinoma |
| title_full | Highly expressed FAM189B predicts poor prognosis in hepatocellular carcinoma |
| title_fullStr | Highly expressed FAM189B predicts poor prognosis in hepatocellular carcinoma |
| title_full_unstemmed | Highly expressed FAM189B predicts poor prognosis in hepatocellular carcinoma |
| title_short | Highly expressed FAM189B predicts poor prognosis in hepatocellular carcinoma |
| title_sort | highly expressed fam189b predicts poor prognosis in hepatocellular carcinoma |
| topic | biomarker prognosis hepatocellular carcinoma clinical significance FAM189B |
| url | https://www.por-journal.com/articles/10.3389/pore.2022.1610674/full |
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