Adequacy of sentinel lymph node biopsy in malignant melanoma of the trunk and extremities: Clinical observations regarding prognosis
Background Methods for identifying local lymph node metastasis in malignant melanoma include sentinel lymph node biopsy (SLNB) and lymph node dissection (LND). In particular, SLNB has been widely used in recent years. This study aimed to retrospectively confirm the adequacy of the current indicatio...
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2020-01-01
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| Series: | Archives of Plastic Surgery |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2019.00934 |
| _version_ | 1797999287455449088 |
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| author | Yong Chan Bae Dae Kyun Jeong Kyoung Hoon Kim Kyung Wook Nam Geon Woo Kim Hoon Soo Kim Su Bong Nam Seong Hwan Bae |
| author_facet | Yong Chan Bae Dae Kyun Jeong Kyoung Hoon Kim Kyung Wook Nam Geon Woo Kim Hoon Soo Kim Su Bong Nam Seong Hwan Bae |
| author_sort | Yong Chan Bae |
| collection | DOAJ |
| description | Background Methods for identifying local lymph node metastasis in malignant melanoma include sentinel lymph node biopsy (SLNB) and lymph node dissection (LND). In particular, SLNB has been widely used in recent years. This study aimed to retrospectively confirm the adequacy of the current indication criteria for SLNB by applying those criteria to a mixed group of patients who previously received SLNB and LND.
Methods This study included 77 patients with malignant melanoma of the extremities and trunk who were monitored for >24 months. The patients were classified according to whether the current indication criteria for SLNB were applicable. The sentinel lymph nodes were evaluated for each group. Patients for whom the indication criteria for SLNB and LND were applicable were analyzed according to whether SLNB or LND was performed. Finally, the outpatient records of these patients were reviewed to evaluate recurrence, metastasis, and prognosis.
Results Of the 77 patients, SLNB was indicated according to the current criteria in 60 cases. Among the 60 patients for whom SLNB was indicated, 35 survived the follow-up period disease-free, 21 died during the follow-up period, and four experienced metastasis. The 17 patients for whom SLNB was not indicated had no recurrence or metastasis.
Conclusions Patients for whom SLNB was not indicated had no recurrence or metastasis. In cases where SLNB is indicated, the possibility of metastasis and recurrence may be high even if SLNB is negative or LND is performed, so more aggressive treatment and careful follow-up are crucial. |
| first_indexed | 2024-04-11T11:02:15Z |
| format | Article |
| id | doaj.art-bd89eb5db2aa4275a76ad64e62d34c87 |
| institution | Directory Open Access Journal |
| issn | 2234-6163 2234-6171 |
| language | English |
| last_indexed | 2024-04-11T11:02:15Z |
| publishDate | 2020-01-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | Archives of Plastic Surgery |
| spelling | doaj.art-bd89eb5db2aa4275a76ad64e62d34c872022-12-22T04:28:34ZengThieme Medical Publishers, Inc.Archives of Plastic Surgery2234-61632234-61712020-01-014701424810.5999/aps.2019.009343700Adequacy of sentinel lymph node biopsy in malignant melanoma of the trunk and extremities: Clinical observations regarding prognosisYong Chan Bae0Dae Kyun Jeong1Kyoung Hoon Kim2Kyung Wook Nam3Geon Woo Kim4Hoon Soo Kim5Su Bong Nam6Seong Hwan Bae7Department of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Busan, KoreaDepartment of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Busan, KoreaBrand Plastic Surgery, Busan, KoreaDepartment of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Busan, KoreaDepartment of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Busan, KoreaDepartment of Dermatology, Pusan National University School of Medicine, Busan, KoreaDepartment of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Busan, KoreaDepartment of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Busan, KoreaBackground Methods for identifying local lymph node metastasis in malignant melanoma include sentinel lymph node biopsy (SLNB) and lymph node dissection (LND). In particular, SLNB has been widely used in recent years. This study aimed to retrospectively confirm the adequacy of the current indication criteria for SLNB by applying those criteria to a mixed group of patients who previously received SLNB and LND. Methods This study included 77 patients with malignant melanoma of the extremities and trunk who were monitored for >24 months. The patients were classified according to whether the current indication criteria for SLNB were applicable. The sentinel lymph nodes were evaluated for each group. Patients for whom the indication criteria for SLNB and LND were applicable were analyzed according to whether SLNB or LND was performed. Finally, the outpatient records of these patients were reviewed to evaluate recurrence, metastasis, and prognosis. Results Of the 77 patients, SLNB was indicated according to the current criteria in 60 cases. Among the 60 patients for whom SLNB was indicated, 35 survived the follow-up period disease-free, 21 died during the follow-up period, and four experienced metastasis. The 17 patients for whom SLNB was not indicated had no recurrence or metastasis. Conclusions Patients for whom SLNB was not indicated had no recurrence or metastasis. In cases where SLNB is indicated, the possibility of metastasis and recurrence may be high even if SLNB is negative or LND is performed, so more aggressive treatment and careful follow-up are crucial.http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2019.00934melanomalymphbiopsyskin neoplasmsprognosis |
| spellingShingle | Yong Chan Bae Dae Kyun Jeong Kyoung Hoon Kim Kyung Wook Nam Geon Woo Kim Hoon Soo Kim Su Bong Nam Seong Hwan Bae Adequacy of sentinel lymph node biopsy in malignant melanoma of the trunk and extremities: Clinical observations regarding prognosis Archives of Plastic Surgery melanoma lymph biopsy skin neoplasms prognosis |
| title | Adequacy of sentinel lymph node biopsy in malignant melanoma of the trunk and extremities: Clinical observations regarding prognosis |
| title_full | Adequacy of sentinel lymph node biopsy in malignant melanoma of the trunk and extremities: Clinical observations regarding prognosis |
| title_fullStr | Adequacy of sentinel lymph node biopsy in malignant melanoma of the trunk and extremities: Clinical observations regarding prognosis |
| title_full_unstemmed | Adequacy of sentinel lymph node biopsy in malignant melanoma of the trunk and extremities: Clinical observations regarding prognosis |
| title_short | Adequacy of sentinel lymph node biopsy in malignant melanoma of the trunk and extremities: Clinical observations regarding prognosis |
| title_sort | adequacy of sentinel lymph node biopsy in malignant melanoma of the trunk and extremities clinical observations regarding prognosis |
| topic | melanoma lymph biopsy skin neoplasms prognosis |
| url | http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2019.00934 |
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