Process development and preclinical evaluation of a major Plasmodium falciparum blood stage vaccine candidate, Cysteine-Rich Protective Antigen (CyRPA)

Process development and preclinical evaluation of a major Plasmodium falciparum blood stage vaccine candidate, Cysteine-Rich Protective Antigen (CyRPA)

Plasmodium falciparum Cysteine-Rich Protective Antigen (CyRPA) is an essential, highly conserved merozoite antigen that forms an important multi-protein complex (RH5/Ripr/CyRPA) necessary for erythrocyte invasion. CyRPA is a promising blood-stage vaccine target that has been shown to elicit potent s...

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Bibliographic Details
Main Authors: Anjali Somanathan, Syed Yusuf Mian, Kritika Chaddha, Seemalata Uchoi, Praveen K. Bharti, Ravi Tandon, Deepak Gaur, Virander Singh Chauhan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
Plasmodium falciparum
CyRPA
gia
adjuvants
recombinant subunit malaria vaccines
humoral and cellular response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1005332/full

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