Dihydroarteannuin Ameliorates Collagen-Induced Arthritis Via Inhibiting B Cell Activation by Activating the FcγRIIb/Lyn/SHP-1 Pathway

Dihydroarteannuin Ameliorates Collagen-Induced Arthritis Via Inhibiting B Cell Activation by Activating the FcγRIIb/Lyn/SHP-1 Pathway

Background: Dihydroarteannuin (DHA), which is extracted from the traditional Chinese herb Artemisia annua L, exhibits potent immunosuppressive activity in rheumatoid arthritis (RA). Strong evidence indicates that B cells act as an essential factor in the pathogenesis of RA, but research on the immun...

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Bibliographic Details
Main Authors: Congqi Hu, Danbin Wu, Jiahui Yu, Jia Xu, Lijuan Liu, Mingying Zhang, Wei Jiao, Guangxing Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
dihydroarteannuin
FcγRIIb
rheumatoid arthritis
ST486
CIA mice
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.883835/full

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