Significance of the apoptotic index, mitotic index, and turnover index in premalignant and malignant squamous cell lesion of the oral cavity: How much is their diagnostic and prognostic role?
Background: Carcinoma of the oral cavity is one of the most common cancers in our country. High mitotic index (MI) rate with growth, proliferation, and carcinoma of tissue linked with a lower survival rate. The combination of MI screening with proliferation and apoptotic assay is more compelling and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Journal of the Scientific Society |
| Subjects: | |
| Online Access: | http://www.jscisociety.com/article.asp?issn=0974-5009;year=2019;volume=46;issue=2;spage=49;epage=52;aulast=Singh |
| _version_ | 1818029747972603904 |
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| author | Preeti Singh Vijay Kumar Ganesh Singh Anshu Singh Ankita Singh |
| author_facet | Preeti Singh Vijay Kumar Ganesh Singh Anshu Singh Ankita Singh |
| author_sort | Preeti Singh |
| collection | DOAJ |
| description | Background: Carcinoma of the oral cavity is one of the most common cancers in our country. High mitotic index (MI) rate with growth, proliferation, and carcinoma of tissue linked with a lower survival rate. The combination of MI screening with proliferation and apoptotic assay is more compelling and comprehensive give more conclusion about anti-proliferative targets. Aim: The study aimed to show the impact of the apoptotic index (AI), MI, and turnover index (TI) to access the behavior of the lesion. Materials and Methods: A total of 68 histologically proven cases of premalignant and malignant squamous cell carcinoma were analyzed over a period of 1 year. Biopsy specimen with hematoxylin and eosin-stained sections was evaluated and correlated with different grade of the oral lesion with AI, MI, and TI. Results: Statistical analysis in premalignant between mild, moderate, and severe dysplasia shows no significant difference, whereas premalignant and malignant show a significant difference. Conclusion: Apoptotic, mitotic, and turnover base index can provide useful information and prediction of the nature of the lesion. |
| first_indexed | 2024-12-10T05:24:37Z |
| format | Article |
| id | doaj.art-bd8b8db866d844d8ab1882f51bb2e58c |
| institution | Directory Open Access Journal |
| issn | 0974-5009 |
| language | English |
| last_indexed | 2024-12-10T05:24:37Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Scientific Society |
| spelling | doaj.art-bd8b8db866d844d8ab1882f51bb2e58c2022-12-22T02:00:43ZengWolters Kluwer Medknow PublicationsJournal of the Scientific Society0974-50092019-01-01462495210.4103/jss.JSS_24_19Significance of the apoptotic index, mitotic index, and turnover index in premalignant and malignant squamous cell lesion of the oral cavity: How much is their diagnostic and prognostic role?Preeti SinghVijay KumarGanesh SinghAnshu SinghAnkita SinghBackground: Carcinoma of the oral cavity is one of the most common cancers in our country. High mitotic index (MI) rate with growth, proliferation, and carcinoma of tissue linked with a lower survival rate. The combination of MI screening with proliferation and apoptotic assay is more compelling and comprehensive give more conclusion about anti-proliferative targets. Aim: The study aimed to show the impact of the apoptotic index (AI), MI, and turnover index (TI) to access the behavior of the lesion. Materials and Methods: A total of 68 histologically proven cases of premalignant and malignant squamous cell carcinoma were analyzed over a period of 1 year. Biopsy specimen with hematoxylin and eosin-stained sections was evaluated and correlated with different grade of the oral lesion with AI, MI, and TI. Results: Statistical analysis in premalignant between mild, moderate, and severe dysplasia shows no significant difference, whereas premalignant and malignant show a significant difference. Conclusion: Apoptotic, mitotic, and turnover base index can provide useful information and prediction of the nature of the lesion.http://www.jscisociety.com/article.asp?issn=0974-5009;year=2019;volume=46;issue=2;spage=49;epage=52;aulast=Singhapoptotic indexmitotic index and turnover indexoral squamous cell carcinoma |
| spellingShingle | Preeti Singh Vijay Kumar Ganesh Singh Anshu Singh Ankita Singh Significance of the apoptotic index, mitotic index, and turnover index in premalignant and malignant squamous cell lesion of the oral cavity: How much is their diagnostic and prognostic role? Journal of the Scientific Society apoptotic index mitotic index and turnover index oral squamous cell carcinoma |
| title | Significance of the apoptotic index, mitotic index, and turnover index in premalignant and malignant squamous cell lesion of the oral cavity: How much is their diagnostic and prognostic role? |
| title_full | Significance of the apoptotic index, mitotic index, and turnover index in premalignant and malignant squamous cell lesion of the oral cavity: How much is their diagnostic and prognostic role? |
| title_fullStr | Significance of the apoptotic index, mitotic index, and turnover index in premalignant and malignant squamous cell lesion of the oral cavity: How much is their diagnostic and prognostic role? |
| title_full_unstemmed | Significance of the apoptotic index, mitotic index, and turnover index in premalignant and malignant squamous cell lesion of the oral cavity: How much is their diagnostic and prognostic role? |
| title_short | Significance of the apoptotic index, mitotic index, and turnover index in premalignant and malignant squamous cell lesion of the oral cavity: How much is their diagnostic and prognostic role? |
| title_sort | significance of the apoptotic index mitotic index and turnover index in premalignant and malignant squamous cell lesion of the oral cavity how much is their diagnostic and prognostic role |
| topic | apoptotic index mitotic index and turnover index oral squamous cell carcinoma |
| url | http://www.jscisociety.com/article.asp?issn=0974-5009;year=2019;volume=46;issue=2;spage=49;epage=52;aulast=Singh |
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