Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study
Abstract Background The effects of corticosteroid-based therapy in patients with idiopathic nonspecific interstitial pneumonia (iNSIP), and factors affecting treatment outcome, are not fully understood. We aimed to investigate the long-term treatment response and factors affecting the treatment outc...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-12-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12931-017-0686-7 |
| _version_ | 1818494194700779520 |
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| author | Sang Hoon Lee Moo Suk Park Song Yee Kim Dong Soon Kim Young Whan Kim Man Pyo Chung Soo Taek Uh Choon Sik Park Sung Woo Park Sung Hwan Jeong Yong Bum Park Hong Lyeol Lee Jong Wook Shin Eun Joo Lee Jin Hwa Lee Yangin Jegal Hyun Kyung Lee Yong Hyun Kim Jin Woo Song Jong Sun Park |
| author_facet | Sang Hoon Lee Moo Suk Park Song Yee Kim Dong Soon Kim Young Whan Kim Man Pyo Chung Soo Taek Uh Choon Sik Park Sung Woo Park Sung Hwan Jeong Yong Bum Park Hong Lyeol Lee Jong Wook Shin Eun Joo Lee Jin Hwa Lee Yangin Jegal Hyun Kyung Lee Yong Hyun Kim Jin Woo Song Jong Sun Park |
| author_sort | Sang Hoon Lee |
| collection | DOAJ |
| description | Abstract Background The effects of corticosteroid-based therapy in patients with idiopathic nonspecific interstitial pneumonia (iNSIP), and factors affecting treatment outcome, are not fully understood. We aimed to investigate the long-term treatment response and factors affecting the treatment outcome in iNSIP patients from a multi-center study in Korea. Methods The Korean interstitial lung disease (ILD) Study Group surveyed ILD patients from 2003 to 2007. Patients were divided into two groups to compare the treatment response: response group (forced vital capacity (FVC) improves ≥10% after 1 year) and non-response group (FVC <10%). Factors affecting treatment response were evaluated by multivariate logistic regression analysis. Results A total of 261 patients with iNSIP were enrolled, and 95 patients were followed-up for more than 1 year. Corticosteroid treatment was performed in 86 patients. The treatment group showed a significant improvement in lung function after 1-year: FVC, 10.0%; forced expiratory volume (FEV1), 9.8%; diffusing capacity of the lung for carbon monoxide (DLco), 8.4% (p < 0.001). Sero-negative anti-nuclear antibody (ANA) was significantly related with lung function improvement. Sero-positivity ANA was significantly lower in the response group (p = 0.013), compared to that in the non-response group. A shorter duration of respiratory symptoms at diagnosis was significantly associated with a good response to treatment (p = 0.018). Conclusion Treatment with corticosteroids and/or immunosuppressants improved lung function in iNSIP patients, which was more pronounced in sero-negative ANA and shorter symptom duration patients. These findings suggest that early treatment should be considered in iNSIP patients, even in an early disease stage. |
| first_indexed | 2024-12-10T18:03:22Z |
| format | Article |
| id | doaj.art-bd8bffc0ccef4b4fb9eb6d0b02ca2549 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-12-10T18:03:22Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-bd8bffc0ccef4b4fb9eb6d0b02ca25492022-12-22T01:38:42ZengBMCRespiratory Research1465-993X2017-12-011811910.1186/s12931-017-0686-7Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort studySang Hoon Lee0Moo Suk Park1Song Yee Kim2Dong Soon Kim3Young Whan Kim4Man Pyo Chung5Soo Taek Uh6Choon Sik Park7Sung Woo Park8Sung Hwan Jeong9Yong Bum Park10Hong Lyeol Lee11Jong Wook Shin12Eun Joo Lee13Jin Hwa Lee14Yangin Jegal15Hyun Kyung Lee16Yong Hyun Kim17Jin Woo Song18Jong Sun Park19Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Seoul National University Bundang HospitalDepartment of Internal Medicine, Division of Pulmonology, Severance Hospital, Institute of Chest Diseases, Yonsei University College of MedicineDepartment of Internal Medicine, Division of Pulmonology, Severance Hospital, Institute of Chest Diseases, Yonsei University College of MedicineDivision of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical CenterDepartment of Internal Medicine and Lung Institute, Division of Pulmonary and Critical Care Medicine, Seoul National University College of MedicineDivision of Pulmonary and Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Internal Medicine, Division of Allergy and Respiratory Medicine, Soonchunhyang University Seoul HospitalDepartment of Internal Medicine, Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon HospitalDepartment of Internal Medicine, Division of Allergy and Respiratory Medicine, Soonchunhyang University Bucheon HospitalDepartment of Internal Medicine, Division of Pulmonology, Gachon University Gil Medical CenterDepartment of Internal Medicine, Division of Pulmonary, Allergy & Critical Care Medicine, Kangdong Sacred Heart Hospital, Hallym UniversityDepartment of Internal Medicine, Pulmonary Division, Inha University HospitalDepartment of Internal medicine, Division of Pulmonary Medicine, Chung Ang University College of MedicineDepartment of Internal Medicine, Division of Respiratory and Critical Care Medicine, Korea University Anam Hospital, Korea University College of MedicineDepartment of Internal Medicine, Ewha Medical Research Institute, Ewha Womans University School of MedicineDepartment of Internal Medicine, Division of Pulmonary Medicine, Ulsan University Hospital, University of Ulsan College of MedicineDepartment of Internal Medicine, Division of Critical Care and Pulmonary Medicine, Inje University Busan Paik HospitalDepartment of Internal Medicine, Division of Allergy and Pulmonology, Bucheon St. Mary’s Hospital, The Catholic University of Korea School of MedicineDivision of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical CenterDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Seoul National University Bundang HospitalAbstract Background The effects of corticosteroid-based therapy in patients with idiopathic nonspecific interstitial pneumonia (iNSIP), and factors affecting treatment outcome, are not fully understood. We aimed to investigate the long-term treatment response and factors affecting the treatment outcome in iNSIP patients from a multi-center study in Korea. Methods The Korean interstitial lung disease (ILD) Study Group surveyed ILD patients from 2003 to 2007. Patients were divided into two groups to compare the treatment response: response group (forced vital capacity (FVC) improves ≥10% after 1 year) and non-response group (FVC <10%). Factors affecting treatment response were evaluated by multivariate logistic regression analysis. Results A total of 261 patients with iNSIP were enrolled, and 95 patients were followed-up for more than 1 year. Corticosteroid treatment was performed in 86 patients. The treatment group showed a significant improvement in lung function after 1-year: FVC, 10.0%; forced expiratory volume (FEV1), 9.8%; diffusing capacity of the lung for carbon monoxide (DLco), 8.4% (p < 0.001). Sero-negative anti-nuclear antibody (ANA) was significantly related with lung function improvement. Sero-positivity ANA was significantly lower in the response group (p = 0.013), compared to that in the non-response group. A shorter duration of respiratory symptoms at diagnosis was significantly associated with a good response to treatment (p = 0.018). Conclusion Treatment with corticosteroids and/or immunosuppressants improved lung function in iNSIP patients, which was more pronounced in sero-negative ANA and shorter symptom duration patients. These findings suggest that early treatment should be considered in iNSIP patients, even in an early disease stage.http://link.springer.com/article/10.1186/s12931-017-0686-7Non-specific interstitial pneumoniaTreatmentPulmonary lung function |
| spellingShingle | Sang Hoon Lee Moo Suk Park Song Yee Kim Dong Soon Kim Young Whan Kim Man Pyo Chung Soo Taek Uh Choon Sik Park Sung Woo Park Sung Hwan Jeong Yong Bum Park Hong Lyeol Lee Jong Wook Shin Eun Joo Lee Jin Hwa Lee Yangin Jegal Hyun Kyung Lee Yong Hyun Kim Jin Woo Song Jong Sun Park Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study Respiratory Research Non-specific interstitial pneumonia Treatment Pulmonary lung function |
| title | Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study |
| title_full | Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study |
| title_fullStr | Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study |
| title_full_unstemmed | Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study |
| title_short | Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study |
| title_sort | factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia a nationwide cohort study |
| topic | Non-specific interstitial pneumonia Treatment Pulmonary lung function |
| url | http://link.springer.com/article/10.1186/s12931-017-0686-7 |
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