Default-mode-like network activation in awake rodents.
During wakefulness and in absence of performing tasks or sensory processing, the default-mode network (DMN), an intrinsic central nervous system (CNS) network, is in an active state. Non-human primate and human CNS imaging studies have identified the DMN in these two species. Clinical imaging studie...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3220684?pdf=render |
| _version_ | 1818610739820101632 |
|---|---|
| author | Jaymin Upadhyay Scott J Baker Prasant Chandran Loan Miller Younglim Lee Gerard J Marek Unal Sakoglu Chih-Liang Chin Feng Luo Gerard B Fox Mark Day |
| author_facet | Jaymin Upadhyay Scott J Baker Prasant Chandran Loan Miller Younglim Lee Gerard J Marek Unal Sakoglu Chih-Liang Chin Feng Luo Gerard B Fox Mark Day |
| author_sort | Jaymin Upadhyay |
| collection | DOAJ |
| description | During wakefulness and in absence of performing tasks or sensory processing, the default-mode network (DMN), an intrinsic central nervous system (CNS) network, is in an active state. Non-human primate and human CNS imaging studies have identified the DMN in these two species. Clinical imaging studies have shown that the pattern of activity within the DMN is often modulated in various disease states (e.g., Alzheimer's, schizophrenia or chronic pain). However, whether the DMN exists in awake rodents has not been characterized. The current data provides evidence that awake rodents also possess 'DMN-like' functional connectivity, but only subsequent to habituation to what is initially a novel magnetic resonance imaging (MRI) environment as well as physical restraint. Specifically, the habituation process spanned across four separate scanning sessions (Day 2, 4, 6 and 8). At Day 8, significant (p<0.05) functional connectivity was observed amongst structures such as the anterior cingulate (seed region), retrosplenial, parietal, and hippocampal cortices. Prior to habituation (Day 2), functional connectivity was only detected (p<0.05) amongst CNS structures known to mediate anxiety (i.e., anterior cingulate (seed region), posterior hypothalamic area, amygdala and parabracial nucleus). In relating functional connectivity between cingulate-default-mode and cingulate-anxiety structures across Days 2-8, a significant inverse relationship (r = -0.65, p = 0.0004) was observed between these two functional interactions such that increased cingulate-DMN connectivity corresponded to decreased cingulate anxiety network connectivity. This investigation demonstrates that the cingulate is an important component of both the rodent DMN-like and anxiety networks. |
| first_indexed | 2024-12-16T15:19:14Z |
| format | Article |
| id | doaj.art-bd8d319d60d941108cea16c1a0f4051a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T15:19:14Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-bd8d319d60d941108cea16c1a0f4051a2022-12-21T22:26:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-01611e2783910.1371/journal.pone.0027839Default-mode-like network activation in awake rodents.Jaymin UpadhyayScott J BakerPrasant ChandranLoan MillerYounglim LeeGerard J MarekUnal SakogluChih-Liang ChinFeng LuoGerard B FoxMark DayDuring wakefulness and in absence of performing tasks or sensory processing, the default-mode network (DMN), an intrinsic central nervous system (CNS) network, is in an active state. Non-human primate and human CNS imaging studies have identified the DMN in these two species. Clinical imaging studies have shown that the pattern of activity within the DMN is often modulated in various disease states (e.g., Alzheimer's, schizophrenia or chronic pain). However, whether the DMN exists in awake rodents has not been characterized. The current data provides evidence that awake rodents also possess 'DMN-like' functional connectivity, but only subsequent to habituation to what is initially a novel magnetic resonance imaging (MRI) environment as well as physical restraint. Specifically, the habituation process spanned across four separate scanning sessions (Day 2, 4, 6 and 8). At Day 8, significant (p<0.05) functional connectivity was observed amongst structures such as the anterior cingulate (seed region), retrosplenial, parietal, and hippocampal cortices. Prior to habituation (Day 2), functional connectivity was only detected (p<0.05) amongst CNS structures known to mediate anxiety (i.e., anterior cingulate (seed region), posterior hypothalamic area, amygdala and parabracial nucleus). In relating functional connectivity between cingulate-default-mode and cingulate-anxiety structures across Days 2-8, a significant inverse relationship (r = -0.65, p = 0.0004) was observed between these two functional interactions such that increased cingulate-DMN connectivity corresponded to decreased cingulate anxiety network connectivity. This investigation demonstrates that the cingulate is an important component of both the rodent DMN-like and anxiety networks.http://europepmc.org/articles/PMC3220684?pdf=render |
| spellingShingle | Jaymin Upadhyay Scott J Baker Prasant Chandran Loan Miller Younglim Lee Gerard J Marek Unal Sakoglu Chih-Liang Chin Feng Luo Gerard B Fox Mark Day Default-mode-like network activation in awake rodents. PLoS ONE |
| title | Default-mode-like network activation in awake rodents. |
| title_full | Default-mode-like network activation in awake rodents. |
| title_fullStr | Default-mode-like network activation in awake rodents. |
| title_full_unstemmed | Default-mode-like network activation in awake rodents. |
| title_short | Default-mode-like network activation in awake rodents. |
| title_sort | default mode like network activation in awake rodents |
| url | http://europepmc.org/articles/PMC3220684?pdf=render |
| work_keys_str_mv | AT jayminupadhyay defaultmodelikenetworkactivationinawakerodents AT scottjbaker defaultmodelikenetworkactivationinawakerodents AT prasantchandran defaultmodelikenetworkactivationinawakerodents AT loanmiller defaultmodelikenetworkactivationinawakerodents AT younglimlee defaultmodelikenetworkactivationinawakerodents AT gerardjmarek defaultmodelikenetworkactivationinawakerodents AT unalsakoglu defaultmodelikenetworkactivationinawakerodents AT chihliangchin defaultmodelikenetworkactivationinawakerodents AT fengluo defaultmodelikenetworkactivationinawakerodents AT gerardbfox defaultmodelikenetworkactivationinawakerodents AT markday defaultmodelikenetworkactivationinawakerodents |