Deep venous thrombosis and acute pericarditis associated with severe acute respiratory syndrome coronavirus 2 infection in a Congolese infant with sickle cell disease: a case report
Abstract Background Since the beginning of the pandemic, no severe pediatric coronavirus disease 2019 cases have been described in Congo. Case We studied a 3-month-old male child of Congolese origin who was admitted to the pediatric department with 7-day history of fever, unilateral lower leg swelli...
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-022-03459-8 |
| _version_ | 1811320963091922944 |
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| author | Toni Kasole Lubala Tony Kayembe-Kitenge Paul Makinko Luguette Kalenga Hénoch Kachil Axel Kayembe Augustin Mutombo Mick Shongo |
| author_facet | Toni Kasole Lubala Tony Kayembe-Kitenge Paul Makinko Luguette Kalenga Hénoch Kachil Axel Kayembe Augustin Mutombo Mick Shongo |
| author_sort | Toni Kasole Lubala |
| collection | DOAJ |
| description | Abstract Background Since the beginning of the pandemic, no severe pediatric coronavirus disease 2019 cases have been described in Congo. Case We studied a 3-month-old male child of Congolese origin who was admitted to the pediatric department with 7-day history of fever, unilateral lower leg swelling, and dyspnea. There was no known history of contact with a coronavirus disease 2019 patient, and all the family members were asymptomatic. Nasopharyngeal swabs done at admission did not detect severe acute respiratory syndrome coronavirus 2. However, serology tests for severe acute respiratory syndrome coronavirus 2 antibodies were positive for immunoglobulin M and negative for immunoglobulin G. Hemoglobin electrophoresis showed hemoglobin A1, hemoglobin A2, hemoglobin F, and hemoglobin S of 46.2%, 2.5%, 19.9%, and 38.4%, respectively. Chest X-ray showed retrocardiac pneumonia in the left lung, and Doppler ultrasound of the left lower limb showed a recent total femoropopliteal venous thrombosis. At day 10 of hospitalization, our patient had classical signs of cardiac tamponade with a voluminous pericardial effusion seen on echocardiographic examination and elevated C-reactive protein, compatible with a diagnosis of constrictive pericarditis. To the best of the authors’ knowledge, this is the first report of a case of plausible severe acute respiratory syndrome coronavirus 2 infection associated with venous thrombosis and acute pericarditis in Congo. Conclusion We hypothesized that this case of venous thrombosis and acute pericarditis in a Congolese child with heterozygous sickle cell disease was related to severe acute respiratory syndrome coronavirus 2 infection. |
| first_indexed | 2024-04-13T13:08:46Z |
| format | Article |
| id | doaj.art-bd8d9b5758ba4cd0b7ff4de471202d68 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-13T13:08:46Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-bd8d9b5758ba4cd0b7ff4de471202d682022-12-22T02:45:40ZengBMCJournal of Medical Case Reports1752-19472022-08-011611410.1186/s13256-022-03459-8Deep venous thrombosis and acute pericarditis associated with severe acute respiratory syndrome coronavirus 2 infection in a Congolese infant with sickle cell disease: a case reportToni Kasole Lubala0Tony Kayembe-Kitenge1Paul Makinko2Luguette Kalenga3Hénoch Kachil4Axel Kayembe5Augustin Mutombo6Mick Shongo7Department of Pediatrics, University of LubumbashiUnit of Toxicology, University of LubumbashiDepartment of Pediatrics, University of LubumbashiDepartment of Pediatrics, CMDC ClinicDepartment of Radiology, CMDC ClinicDepartment of Radiology, CMDC ClinicDepartment of Pediatrics, University of LubumbashiDepartment of Pediatrics, University of LubumbashiAbstract Background Since the beginning of the pandemic, no severe pediatric coronavirus disease 2019 cases have been described in Congo. Case We studied a 3-month-old male child of Congolese origin who was admitted to the pediatric department with 7-day history of fever, unilateral lower leg swelling, and dyspnea. There was no known history of contact with a coronavirus disease 2019 patient, and all the family members were asymptomatic. Nasopharyngeal swabs done at admission did not detect severe acute respiratory syndrome coronavirus 2. However, serology tests for severe acute respiratory syndrome coronavirus 2 antibodies were positive for immunoglobulin M and negative for immunoglobulin G. Hemoglobin electrophoresis showed hemoglobin A1, hemoglobin A2, hemoglobin F, and hemoglobin S of 46.2%, 2.5%, 19.9%, and 38.4%, respectively. Chest X-ray showed retrocardiac pneumonia in the left lung, and Doppler ultrasound of the left lower limb showed a recent total femoropopliteal venous thrombosis. At day 10 of hospitalization, our patient had classical signs of cardiac tamponade with a voluminous pericardial effusion seen on echocardiographic examination and elevated C-reactive protein, compatible with a diagnosis of constrictive pericarditis. To the best of the authors’ knowledge, this is the first report of a case of plausible severe acute respiratory syndrome coronavirus 2 infection associated with venous thrombosis and acute pericarditis in Congo. Conclusion We hypothesized that this case of venous thrombosis and acute pericarditis in a Congolese child with heterozygous sickle cell disease was related to severe acute respiratory syndrome coronavirus 2 infection.https://doi.org/10.1186/s13256-022-03459-8ThrombosisPericarditisSARS-CoV-2Sickle cell diseaseCongo |
| spellingShingle | Toni Kasole Lubala Tony Kayembe-Kitenge Paul Makinko Luguette Kalenga Hénoch Kachil Axel Kayembe Augustin Mutombo Mick Shongo Deep venous thrombosis and acute pericarditis associated with severe acute respiratory syndrome coronavirus 2 infection in a Congolese infant with sickle cell disease: a case report Journal of Medical Case Reports Thrombosis Pericarditis SARS-CoV-2 Sickle cell disease Congo |
| title | Deep venous thrombosis and acute pericarditis associated with severe acute respiratory syndrome coronavirus 2 infection in a Congolese infant with sickle cell disease: a case report |
| title_full | Deep venous thrombosis and acute pericarditis associated with severe acute respiratory syndrome coronavirus 2 infection in a Congolese infant with sickle cell disease: a case report |
| title_fullStr | Deep venous thrombosis and acute pericarditis associated with severe acute respiratory syndrome coronavirus 2 infection in a Congolese infant with sickle cell disease: a case report |
| title_full_unstemmed | Deep venous thrombosis and acute pericarditis associated with severe acute respiratory syndrome coronavirus 2 infection in a Congolese infant with sickle cell disease: a case report |
| title_short | Deep venous thrombosis and acute pericarditis associated with severe acute respiratory syndrome coronavirus 2 infection in a Congolese infant with sickle cell disease: a case report |
| title_sort | deep venous thrombosis and acute pericarditis associated with severe acute respiratory syndrome coronavirus 2 infection in a congolese infant with sickle cell disease a case report |
| topic | Thrombosis Pericarditis SARS-CoV-2 Sickle cell disease Congo |
| url | https://doi.org/10.1186/s13256-022-03459-8 |
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