Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate
Heterogeneous populations of basal cells in the prostate epithelium contain stem cells. Here the authors show that Zeb1 marks a pool of prostate epithelial stem cells that self-renew, generate prostate glandular structures with all 3 epithelial cell types and are required for prostate basal cell dev...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14296-y |
| _version_ | 1830281875680133120 |
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| author | Xue Wang Haibo Xu Chaping Cheng Zhongzhong Ji Huifang Zhao Yaru Sheng Xiaoxia Li Jinming Wang Yu Shu Yuman He Liancheng Fan Baijun Dong Wei Xue Chee Wai Chua Dongdong Wu Wei-Qiang Gao Helen He Zhu |
| author_facet | Xue Wang Haibo Xu Chaping Cheng Zhongzhong Ji Huifang Zhao Yaru Sheng Xiaoxia Li Jinming Wang Yu Shu Yuman He Liancheng Fan Baijun Dong Wei Xue Chee Wai Chua Dongdong Wu Wei-Qiang Gao Helen He Zhu |
| author_sort | Xue Wang |
| collection | DOAJ |
| description | Heterogeneous populations of basal cells in the prostate epithelium contain stem cells. Here the authors show that Zeb1 marks a pool of prostate epithelial stem cells that self-renew, generate prostate glandular structures with all 3 epithelial cell types and are required for prostate basal cell development. |
| first_indexed | 2024-12-19T02:27:43Z |
| format | Article |
| id | doaj.art-bd8edfecd5cc4953a997a60f4c5ace58 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T02:27:43Z |
| publishDate | 2020-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bd8edfecd5cc4953a997a60f4c5ace582022-12-21T20:39:53ZengNature PortfolioNature Communications2041-17232020-02-0111111610.1038/s41467-020-14296-yIdentification of a Zeb1 expressing basal stem cell subpopulation in the prostateXue Wang0Haibo Xu1Chaping Cheng2Zhongzhong Ji3Huifang Zhao4Yaru Sheng5Xiaoxia Li6Jinming Wang7Yu Shu8Yuman He9Liancheng Fan10Baijun Dong11Wei Xue12Chee Wai Chua13Dongdong Wu14Wei-Qiang Gao15Helen He Zhu16State Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong UniversityState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of SciencesState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong UniversityState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong UniversityState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong UniversityState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong UniversityState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong UniversityState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong UniversityState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong UniversityState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong UniversityDepartment of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong UniversityState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of SciencesState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong UniversityState Key Laboratory of Oncogenes and Related Genes, Renji-Med-X Stem Cell Research Center, Department of Urology, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong UniversityHeterogeneous populations of basal cells in the prostate epithelium contain stem cells. Here the authors show that Zeb1 marks a pool of prostate epithelial stem cells that self-renew, generate prostate glandular structures with all 3 epithelial cell types and are required for prostate basal cell development.https://doi.org/10.1038/s41467-020-14296-y |
| spellingShingle | Xue Wang Haibo Xu Chaping Cheng Zhongzhong Ji Huifang Zhao Yaru Sheng Xiaoxia Li Jinming Wang Yu Shu Yuman He Liancheng Fan Baijun Dong Wei Xue Chee Wai Chua Dongdong Wu Wei-Qiang Gao Helen He Zhu Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate Nature Communications |
| title | Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate |
| title_full | Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate |
| title_fullStr | Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate |
| title_full_unstemmed | Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate |
| title_short | Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate |
| title_sort | identification of a zeb1 expressing basal stem cell subpopulation in the prostate |
| url | https://doi.org/10.1038/s41467-020-14296-y |
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