Episodes from the Continuous Search for Solutions against Downy Mildew Diseases
Discovery background, lead optimization pathways, synthesis and structure–activity relationships of three different research projects searching for new active ingredients against downy mildew diseases are reported. These case studies, on which the author worked in three different decades i...
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2019-08-01
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| Series: | CHIMIA |
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| Online Access: | https://www.chimia.ch/chimia/article/view/1281 |
| _version_ | 1828863827351961600 |
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| author | Clemens Lamberth |
| author_facet | Clemens Lamberth |
| author_sort | Clemens Lamberth |
| collection | DOAJ |
| description |
Discovery background, lead optimization pathways, synthesis and structure–activity relationships of three different research projects searching for new active ingredients against downy mildew diseases are reported. These case studies, on which the author worked in three different
decades in the research departments of Syngenta Crop Protection AG and its legacy company Novartis Crop Protection AG deal with inhibitors of cellulose synthase, tubulin polymerization and oxysterol-binding protein. Rarely used reactions, which have been applied within these projects, such
as Seebach's variation of the Passerini reaction, the Bogert quinazoline synthesis and the carbonyldiimidazole-mediated Lossen rearrangement give proof of the significance of synthetic organic chemistry for modern crop protection.
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| first_indexed | 2024-12-13T03:52:31Z |
| format | Article |
| id | doaj.art-bd8f9013fa9d4c60870344d6c0e43bed |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-12-13T03:52:31Z |
| publishDate | 2019-08-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-bd8f9013fa9d4c60870344d6c0e43bed2022-12-22T00:00:41ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242019-08-01737-810.2533/chimia.2019.571Episodes from the Continuous Search for Solutions against Downy Mildew DiseasesClemens Lamberth0Syngenta Crop Protection AG, Research Chemistry, Schaffhauserstrasse 101, CH-4332 Stein;, Email: clemens.lamberth@syngenta.com Discovery background, lead optimization pathways, synthesis and structure–activity relationships of three different research projects searching for new active ingredients against downy mildew diseases are reported. These case studies, on which the author worked in three different decades in the research departments of Syngenta Crop Protection AG and its legacy company Novartis Crop Protection AG deal with inhibitors of cellulose synthase, tubulin polymerization and oxysterol-binding protein. Rarely used reactions, which have been applied within these projects, such as Seebach's variation of the Passerini reaction, the Bogert quinazoline synthesis and the carbonyldiimidazole-mediated Lossen rearrangement give proof of the significance of synthetic organic chemistry for modern crop protection. https://www.chimia.ch/chimia/article/view/1281AgrochemicalCrop protectionFungicideMandipropamidOomycete |
| spellingShingle | Clemens Lamberth Episodes from the Continuous Search for Solutions against Downy Mildew Diseases CHIMIA Agrochemical Crop protection Fungicide Mandipropamid Oomycete |
| title | Episodes from the Continuous Search for Solutions against Downy Mildew Diseases |
| title_full | Episodes from the Continuous Search for Solutions against Downy Mildew Diseases |
| title_fullStr | Episodes from the Continuous Search for Solutions against Downy Mildew Diseases |
| title_full_unstemmed | Episodes from the Continuous Search for Solutions against Downy Mildew Diseases |
| title_short | Episodes from the Continuous Search for Solutions against Downy Mildew Diseases |
| title_sort | episodes from the continuous search for solutions against downy mildew diseases |
| topic | Agrochemical Crop protection Fungicide Mandipropamid Oomycete |
| url | https://www.chimia.ch/chimia/article/view/1281 |
| work_keys_str_mv | AT clemenslamberth episodesfromthecontinuoussearchforsolutionsagainstdownymildewdiseases |