Rapid Actions of the Nuclear Progesterone Receptor through cSrc in Cancer
The nuclear progesterone receptor (PR) is mainly known for its role as a ligand-regulated transcription factor. However, in the last ten years, this receptor’s extranuclear or rapid actions have gained importance in the context of physiological and pathophysiological conditions such as cancer. The P...
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MDPI AG
2022-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/12/1964 |
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| author | Claudia Bello-Alvarez Carmen J. Zamora-Sánchez Ignacio Camacho-Arroyo |
| author_facet | Claudia Bello-Alvarez Carmen J. Zamora-Sánchez Ignacio Camacho-Arroyo |
| author_sort | Claudia Bello-Alvarez |
| collection | DOAJ |
| description | The nuclear progesterone receptor (PR) is mainly known for its role as a ligand-regulated transcription factor. However, in the last ten years, this receptor’s extranuclear or rapid actions have gained importance in the context of physiological and pathophysiological conditions such as cancer. The PR’s polyproline (PXPP) motif allows protein–protein interaction through SH3 domains of several cytoplasmatic proteins, including the Src family kinases (SFKs). Among members of this family, cSrc is the most well-characterized protein in the scenario of rapid actions of the PR in cancer. Studies in breast cancer have provided the most detailed information on the signaling and effects triggered by the cSrc–PR interaction. Nevertheless, the study of this phenomenon and its consequences has been underestimated in other types of malignancies, especially those not associated with the reproductive system, such as glioblastomas (GBs). This review will provide a detailed analysis of the impact of the PR–cSrc interplay in the progression of some non-reproductive cancers, particularly, in GBs. |
| first_indexed | 2024-03-10T00:09:29Z |
| format | Article |
| id | doaj.art-bd8fe99d65bb49f3b4b093cf6e50369d |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:09:29Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-bd8fe99d65bb49f3b4b093cf6e50369d2023-11-23T16:02:18ZengMDPI AGCells2073-44092022-06-011112196410.3390/cells11121964Rapid Actions of the Nuclear Progesterone Receptor through cSrc in CancerClaudia Bello-Alvarez0Carmen J. Zamora-Sánchez1Ignacio Camacho-Arroyo2Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México C.P. 0451, MexicoUnidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México C.P. 0451, MexicoUnidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México C.P. 0451, MexicoThe nuclear progesterone receptor (PR) is mainly known for its role as a ligand-regulated transcription factor. However, in the last ten years, this receptor’s extranuclear or rapid actions have gained importance in the context of physiological and pathophysiological conditions such as cancer. The PR’s polyproline (PXPP) motif allows protein–protein interaction through SH3 domains of several cytoplasmatic proteins, including the Src family kinases (SFKs). Among members of this family, cSrc is the most well-characterized protein in the scenario of rapid actions of the PR in cancer. Studies in breast cancer have provided the most detailed information on the signaling and effects triggered by the cSrc–PR interaction. Nevertheless, the study of this phenomenon and its consequences has been underestimated in other types of malignancies, especially those not associated with the reproductive system, such as glioblastomas (GBs). This review will provide a detailed analysis of the impact of the PR–cSrc interplay in the progression of some non-reproductive cancers, particularly, in GBs.https://www.mdpi.com/2073-4409/11/12/1964nuclear progesterone receptorcSrcrapid actionsbreast cancerglioblastoma |
| spellingShingle | Claudia Bello-Alvarez Carmen J. Zamora-Sánchez Ignacio Camacho-Arroyo Rapid Actions of the Nuclear Progesterone Receptor through cSrc in Cancer Cells nuclear progesterone receptor cSrc rapid actions breast cancer glioblastoma |
| title | Rapid Actions of the Nuclear Progesterone Receptor through cSrc in Cancer |
| title_full | Rapid Actions of the Nuclear Progesterone Receptor through cSrc in Cancer |
| title_fullStr | Rapid Actions of the Nuclear Progesterone Receptor through cSrc in Cancer |
| title_full_unstemmed | Rapid Actions of the Nuclear Progesterone Receptor through cSrc in Cancer |
| title_short | Rapid Actions of the Nuclear Progesterone Receptor through cSrc in Cancer |
| title_sort | rapid actions of the nuclear progesterone receptor through csrc in cancer |
| topic | nuclear progesterone receptor cSrc rapid actions breast cancer glioblastoma |
| url | https://www.mdpi.com/2073-4409/11/12/1964 |
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