Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chattogram Metropolitan Area, Bangladesh
Seroprevalence studies of COVID-19 are used to assess the degree of undetected transmission in the community and different groups such as health care workers (HCWs) are deemed vulnerable due to their workplace hazards. The present study estimated the seroprevalence and quantified the titer of anti-S...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Antibodies |
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| Online Access: | https://www.mdpi.com/2073-4468/11/4/69 |
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| author | Jahan Ara Md. Sirazul Islam Md. Tarek Ul Quader Anan Das F. M. Yasir Hasib Mohammad Saiful Islam Tazrina Rahman Seemanta Das M. A. Hassan Chowdhury Goutam Buddha Das Sharmin Chowdhury |
| author_facet | Jahan Ara Md. Sirazul Islam Md. Tarek Ul Quader Anan Das F. M. Yasir Hasib Mohammad Saiful Islam Tazrina Rahman Seemanta Das M. A. Hassan Chowdhury Goutam Buddha Das Sharmin Chowdhury |
| author_sort | Jahan Ara |
| collection | DOAJ |
| description | Seroprevalence studies of COVID-19 are used to assess the degree of undetected transmission in the community and different groups such as health care workers (HCWs) are deemed vulnerable due to their workplace hazards. The present study estimated the seroprevalence and quantified the titer of anti-SARS-CoV-2 antibody (IgG) and its association with different factors. This cross-sectional study observed HCWs, in indoor and outdoor patients (non-COVID-19) and garment workers in the Chattogram metropolitan area (CMA, N = 748) from six hospitals and two garment factories. Qualitative and quantitative ELISA were used to identify and quantify antibodies (IgG) in the serum samples. Descriptive, univariable, and multivariable statistical analysis were performed. Overall seroprevalence and among HCWs, in indoor and outdoor patients, and garment workers were 66.99% (95% CI: 63.40–70.40%), 68.99% (95% CI: 63.8–73.7%), 81.37% (95% CI: 74.7–86.7%), and 50.56% (95% CI: 43.5–57.5%), respectively. Seroprevalence and mean titer was 44.47% (95% CI: 38.6–50.4%) and 53.71 DU/mL in the non-vaccinated population, respectively, while it was higher in the population who received a first dose (61.66%, 95% CI: 54.8–68.0%, 159.08 DU/mL) and both doses (100%, 95% CI: 98.4–100%, 255.46 DU/mL). This study emphasizes the role of vaccine in antibody production; the second dose of vaccine significantly increased the seroprevalence and titer and both were low in natural infection. |
| first_indexed | 2024-03-09T17:24:21Z |
| format | Article |
| id | doaj.art-bd96873886cc47bdb0404c246c323aa6 |
| institution | Directory Open Access Journal |
| issn | 2073-4468 |
| language | English |
| last_indexed | 2024-03-09T17:24:21Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibodies |
| spelling | doaj.art-bd96873886cc47bdb0404c246c323aa62023-11-24T12:55:35ZengMDPI AGAntibodies2073-44682022-11-011146910.3390/antib11040069Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chattogram Metropolitan Area, BangladeshJahan Ara0Md. Sirazul Islam1Md. Tarek Ul Quader2Anan Das3F. M. Yasir Hasib4Mohammad Saiful Islam5Tazrina Rahman6Seemanta Das7M. A. Hassan Chowdhury8Goutam Buddha Das9Sharmin Chowdhury10One Health Institute, Chattogram Veterinary and Animal Sciences University, Khulshi, Chattogram 4225, BangladeshDepartment of Pathology and Parasitology, Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University, Khulshi, Chattogram 4225, BangladeshDepartment of Anesthesiology and ICU, Chittagong Medical College Hospital, Chattogram 4203, BangladeshOne Health Institute, Chattogram Veterinary and Animal Sciences University, Khulshi, Chattogram 4225, BangladeshDepartment of Pathology and Parasitology, Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University, Khulshi, Chattogram 4225, BangladeshDepartment of Emergency and Accident, Imperial Hospital Limited, Chattogram 4202, BangladeshDepartment of Microbiology and Virology, Chittagong Medical College, Chattogram 4203, BangladeshOne Health Institute, Chattogram Veterinary and Animal Sciences University, Khulshi, Chattogram 4225, BangladeshDepartment of Medicine, Chittagong Medical College, Chattogram 4203, BangladeshCOVID-19 Detection Laboratory, Chattogram Veterinary and Animal Sciences University, Khulshi, Chattogram 4225, BangladeshOne Health Institute, Chattogram Veterinary and Animal Sciences University, Khulshi, Chattogram 4225, BangladeshSeroprevalence studies of COVID-19 are used to assess the degree of undetected transmission in the community and different groups such as health care workers (HCWs) are deemed vulnerable due to their workplace hazards. The present study estimated the seroprevalence and quantified the titer of anti-SARS-CoV-2 antibody (IgG) and its association with different factors. This cross-sectional study observed HCWs, in indoor and outdoor patients (non-COVID-19) and garment workers in the Chattogram metropolitan area (CMA, N = 748) from six hospitals and two garment factories. Qualitative and quantitative ELISA were used to identify and quantify antibodies (IgG) in the serum samples. Descriptive, univariable, and multivariable statistical analysis were performed. Overall seroprevalence and among HCWs, in indoor and outdoor patients, and garment workers were 66.99% (95% CI: 63.40–70.40%), 68.99% (95% CI: 63.8–73.7%), 81.37% (95% CI: 74.7–86.7%), and 50.56% (95% CI: 43.5–57.5%), respectively. Seroprevalence and mean titer was 44.47% (95% CI: 38.6–50.4%) and 53.71 DU/mL in the non-vaccinated population, respectively, while it was higher in the population who received a first dose (61.66%, 95% CI: 54.8–68.0%, 159.08 DU/mL) and both doses (100%, 95% CI: 98.4–100%, 255.46 DU/mL). This study emphasizes the role of vaccine in antibody production; the second dose of vaccine significantly increased the seroprevalence and titer and both were low in natural infection.https://www.mdpi.com/2073-4468/11/4/69seroprevalenceanti-SARS-CoV-2 antibodyantibody titerIgG |
| spellingShingle | Jahan Ara Md. Sirazul Islam Md. Tarek Ul Quader Anan Das F. M. Yasir Hasib Mohammad Saiful Islam Tazrina Rahman Seemanta Das M. A. Hassan Chowdhury Goutam Buddha Das Sharmin Chowdhury Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chattogram Metropolitan Area, Bangladesh Antibodies seroprevalence anti-SARS-CoV-2 antibody antibody titer IgG |
| title | Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chattogram Metropolitan Area, Bangladesh |
| title_full | Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chattogram Metropolitan Area, Bangladesh |
| title_fullStr | Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chattogram Metropolitan Area, Bangladesh |
| title_full_unstemmed | Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chattogram Metropolitan Area, Bangladesh |
| title_short | Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chattogram Metropolitan Area, Bangladesh |
| title_sort | seroprevalence of anti sars cov 2 antibodies in chattogram metropolitan area bangladesh |
| topic | seroprevalence anti-SARS-CoV-2 antibody antibody titer IgG |
| url | https://www.mdpi.com/2073-4468/11/4/69 |
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