The use of Gene-Xpert MTB RIF in the diagnosis of extrapulmonary tuberculosis in childhood and adolescence
Abstract INTRODUCTION: Gene-Xpert MTB RIF (Xpert) is based on nucleic acid amplification by real-time polymerase chain reaction, which allows for the identification of Mycobacterium tuberculosis and rifampin resistance. We describe the use of Xpert for extrapulmonary tuberculosis (EPTB) in childre...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2020-10-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100664&tlng=en |
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| author | Rafaela Baroni Aurilio Vivian Vidal Marsili Thiago da Silva Santos Malaquias Afrânio Lineu Kritski Clemax Couto Sant’Anna |
| author_facet | Rafaela Baroni Aurilio Vivian Vidal Marsili Thiago da Silva Santos Malaquias Afrânio Lineu Kritski Clemax Couto Sant’Anna |
| author_sort | Rafaela Baroni Aurilio |
| collection | DOAJ |
| description | Abstract INTRODUCTION: Gene-Xpert MTB RIF (Xpert) is based on nucleic acid amplification by real-time polymerase chain reaction, which allows for the identification of Mycobacterium tuberculosis and rifampin resistance. We describe the use of Xpert for extrapulmonary tuberculosis (EPTB) in children and adolescents. METHODS: A case series of two reference centers in Rio de Janeiro from 2014-2019. RESULTS: The final diagnosis of EPTB was established in 11/36 (31%) patients, with five cases detectable by Xpert. For lymph node evaluation (9/11), diagnosis by Xpert occurred in 5/9 patients, all with caseous aspects. CONCLUSIONS: Xpert can facilitate the rapid diagnosis of lymph node tuberculosis. |
| first_indexed | 2024-04-13T22:34:37Z |
| format | Article |
| id | doaj.art-bd9a2824f1b844f1b88dbf91492b4dc8 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-13T22:34:37Z |
| publishDate | 2020-10-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-bd9a2824f1b844f1b88dbf91492b4dc82022-12-22T02:26:49ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492020-10-015310.1590/0037-8682-0104-2020The use of Gene-Xpert MTB RIF in the diagnosis of extrapulmonary tuberculosis in childhood and adolescenceRafaela Baroni Auriliohttps://orcid.org/0000-0003-2727-520XVivian Vidal MarsiliThiago da Silva Santos MalaquiasAfrânio Lineu KritskiClemax Couto Sant’AnnaAbstract INTRODUCTION: Gene-Xpert MTB RIF (Xpert) is based on nucleic acid amplification by real-time polymerase chain reaction, which allows for the identification of Mycobacterium tuberculosis and rifampin resistance. We describe the use of Xpert for extrapulmonary tuberculosis (EPTB) in children and adolescents. METHODS: A case series of two reference centers in Rio de Janeiro from 2014-2019. RESULTS: The final diagnosis of EPTB was established in 11/36 (31%) patients, with five cases detectable by Xpert. For lymph node evaluation (9/11), diagnosis by Xpert occurred in 5/9 patients, all with caseous aspects. CONCLUSIONS: Xpert can facilitate the rapid diagnosis of lymph node tuberculosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100664&tlng=enExtrapulmonaryTuberculosisChildAdolescent |
| spellingShingle | Rafaela Baroni Aurilio Vivian Vidal Marsili Thiago da Silva Santos Malaquias Afrânio Lineu Kritski Clemax Couto Sant’Anna The use of Gene-Xpert MTB RIF in the diagnosis of extrapulmonary tuberculosis in childhood and adolescence Revista da Sociedade Brasileira de Medicina Tropical Extrapulmonary Tuberculosis Child Adolescent |
| title | The use of Gene-Xpert MTB RIF in the diagnosis of extrapulmonary tuberculosis in childhood and adolescence |
| title_full | The use of Gene-Xpert MTB RIF in the diagnosis of extrapulmonary tuberculosis in childhood and adolescence |
| title_fullStr | The use of Gene-Xpert MTB RIF in the diagnosis of extrapulmonary tuberculosis in childhood and adolescence |
| title_full_unstemmed | The use of Gene-Xpert MTB RIF in the diagnosis of extrapulmonary tuberculosis in childhood and adolescence |
| title_short | The use of Gene-Xpert MTB RIF in the diagnosis of extrapulmonary tuberculosis in childhood and adolescence |
| title_sort | use of gene xpert mtb rif in the diagnosis of extrapulmonary tuberculosis in childhood and adolescence |
| topic | Extrapulmonary Tuberculosis Child Adolescent |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100664&tlng=en |
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