The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2

Diacylglycerol acyltransferase (DGAT) catalyzes the final step in triglyceride (TG) synthesis. There are two isoforms, DGAT1 and DGAT2, with distinct protein sequences and potentially different physiological functions. To date, the ability to determine clear functional differences between DGAT1 and...

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Bibliographic Details
Main Authors: Jenson Qi, Wensheng Lang, John G. Geisler, Ping Wang, Ioanna Petrounia, Selyna Mai, Charles Smith, Hossein Askari, Geoffrey T. Struble, Robyn Williams, Sanjay Bhanot, Brett P. Monia, Shariff Bayoumy, Eugene Grant, Gary W. Caldwell, Matthew J. Todd, Yin Liang, Micheal D. Gaul, Keith T. Demarest, Margery A. Connelly
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Journal of Lipid Research
Subjects:
diacylglycerol acyltransferase
triglyceride synthesis
very low density lipoprotein triglyceride
liquid chromatography tandem mass spectrometry
13C3-D5-glycerol
13C18-oleic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752031703X

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http://www.sciencedirect.com/science/article/pii/S002222752031703X

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