Safety and immunogenicity of synchronous COVID19 and influenza vaccination
Given the ongoing COVID19 pandemic, the decline in serological response since dose 2, and the upcoming flu season, COVID19 vaccines will increasingly be administered in combination with vaccines against seasonal pathogens. It is of interest to confirm that concurrent vaccination against influenzavir...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Journal of Clinical Virology Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667038022000217 |
| _version_ | 1828321995341692928 |
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| author | Andreina Baj Daniela Dalla Gasperina Daniele Focosi Greta Forlani Francesca Drago Ferrante Federica Novazzi Lorenzo Azzi Fabrizio Maggi |
| author_facet | Andreina Baj Daniela Dalla Gasperina Daniele Focosi Greta Forlani Francesca Drago Ferrante Federica Novazzi Lorenzo Azzi Fabrizio Maggi |
| author_sort | Andreina Baj |
| collection | DOAJ |
| description | Given the ongoing COVID19 pandemic, the decline in serological response since dose 2, and the upcoming flu season, COVID19 vaccines will increasingly be administered in combination with vaccines against seasonal pathogens. It is of interest to confirm that concurrent vaccination against influenzavirus has no negative impact on serological response to SARS CoV-2.Anti-Spike IgG and Anti-Receptor Binding Domain (RBD) Neutralizing Antibodies (NAb) in serum was assessed in 64 immunocompetent healthcare workers (HCW) before and 14 days post the third dose of BNT162b2 vaccine (Comirnaty®, Pfizer/BioNTech) or BNT162b2 plus quadrivalent flu vaccine (Vaxigript Tetra ®Sanofi Pasteur) on the same day.We report here safety and efficacy of combined BNT162b2 and flu vaccine in 64 healthcare workers at a single institution. No differences were found in adverse events or anti-Spike antibody levels. |
| first_indexed | 2024-04-13T18:35:29Z |
| format | Article |
| id | doaj.art-bd9d7e711c0d44a2b3b91dca1539c2b8 |
| institution | Directory Open Access Journal |
| issn | 2667-0380 |
| language | English |
| last_indexed | 2024-04-13T18:35:29Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical Virology Plus |
| spelling | doaj.art-bd9d7e711c0d44a2b3b91dca1539c2b82022-12-22T02:34:55ZengElsevierJournal of Clinical Virology Plus2667-03802022-08-0123100082Safety and immunogenicity of synchronous COVID19 and influenza vaccinationAndreina Baj0Daniela Dalla Gasperina1Daniele Focosi2Greta Forlani3Francesca Drago Ferrante4Federica Novazzi5Lorenzo Azzi6Fabrizio Maggi7Department of Medicine and Surgery, University of Insubria, Varese, Italy; Laboratory of Microbiology, ASST Sette Laghi, Varese, Italy; Corresponding author at: Department of Medicine and Surgery, University of Insubria, Varese, ItalyDepartment of Medicine and Surgery, University of Insubria, Varese, ItalyNorth-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, ItalyDepartment of Medicine and Surgery, University of Insubria, Varese, ItalyLaboratory of Microbiology, ASST Sette Laghi, Varese, ItalyLaboratory of Microbiology, ASST Sette Laghi, Varese, ItalyDepartment of Medicine and Surgery, University of Insubria, Varese, Italy; Unit of Oral Medicine and Pathology, ASST Sette Laghi, Varese, ItalyDepartment of Medicine and Surgery, University of Insubria, Varese, Italy; Laboratory of Microbiology, ASST Sette Laghi, Varese, ItalyGiven the ongoing COVID19 pandemic, the decline in serological response since dose 2, and the upcoming flu season, COVID19 vaccines will increasingly be administered in combination with vaccines against seasonal pathogens. It is of interest to confirm that concurrent vaccination against influenzavirus has no negative impact on serological response to SARS CoV-2.Anti-Spike IgG and Anti-Receptor Binding Domain (RBD) Neutralizing Antibodies (NAb) in serum was assessed in 64 immunocompetent healthcare workers (HCW) before and 14 days post the third dose of BNT162b2 vaccine (Comirnaty®, Pfizer/BioNTech) or BNT162b2 plus quadrivalent flu vaccine (Vaxigript Tetra ®Sanofi Pasteur) on the same day.We report here safety and efficacy of combined BNT162b2 and flu vaccine in 64 healthcare workers at a single institution. No differences were found in adverse events or anti-Spike antibody levels.http://www.sciencedirect.com/science/article/pii/S2667038022000217SARS-CoV-2COVID-19Healthcare workersInfluenzavirusVaccinationSerology |
| spellingShingle | Andreina Baj Daniela Dalla Gasperina Daniele Focosi Greta Forlani Francesca Drago Ferrante Federica Novazzi Lorenzo Azzi Fabrizio Maggi Safety and immunogenicity of synchronous COVID19 and influenza vaccination Journal of Clinical Virology Plus SARS-CoV-2 COVID-19 Healthcare workers Influenzavirus Vaccination Serology |
| title | Safety and immunogenicity of synchronous COVID19 and influenza vaccination |
| title_full | Safety and immunogenicity of synchronous COVID19 and influenza vaccination |
| title_fullStr | Safety and immunogenicity of synchronous COVID19 and influenza vaccination |
| title_full_unstemmed | Safety and immunogenicity of synchronous COVID19 and influenza vaccination |
| title_short | Safety and immunogenicity of synchronous COVID19 and influenza vaccination |
| title_sort | safety and immunogenicity of synchronous covid19 and influenza vaccination |
| topic | SARS-CoV-2 COVID-19 Healthcare workers Influenzavirus Vaccination Serology |
| url | http://www.sciencedirect.com/science/article/pii/S2667038022000217 |
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