Pathogenicity of H5N8 High Pathogenicity Avian Influenza Virus in Chickens and Ducks from South Korea in 2020–2021
During the 2020–2021 winter season, an outbreak of clade 2.3.4.4b H5N8 high pathogenicity avian influenza (HPAI) virus occurred in South Korea. Here, we evaluated the pathogenicity and transmissibility of A/mandarin duck/Korea/H242/2020 (H5N8) (H242/20(H5N8)) first isolated from this outbreak in spe...
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MDPI AG
2021-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/10/1903 |
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| author | Min-Ji Park Ra Mi Cha Soo-Jeong Kye Yu-Na Lee Na-Yeong Kim Yoon-Gi Baek Gyeong-Beom Heo Mingeun Sagong Kwang-Nyeong Lee Youn-Jeong Lee Eun-Kyoung Lee |
| author_facet | Min-Ji Park Ra Mi Cha Soo-Jeong Kye Yu-Na Lee Na-Yeong Kim Yoon-Gi Baek Gyeong-Beom Heo Mingeun Sagong Kwang-Nyeong Lee Youn-Jeong Lee Eun-Kyoung Lee |
| author_sort | Min-Ji Park |
| collection | DOAJ |
| description | During the 2020–2021 winter season, an outbreak of clade 2.3.4.4b H5N8 high pathogenicity avian influenza (HPAI) virus occurred in South Korea. Here, we evaluated the pathogenicity and transmissibility of A/mandarin duck/Korea/H242/2020 (H5N8) (H242/20(H5N8)) first isolated from this outbreak in specific pathogen-free (SPF) chickens and commercial ducks in comparison with those of A/duck/Korea/HD1/2017(H5N6) (HD1/17(H5N6)) from a previous HPAI outbreak in 2017–2018. In chickens, the 50% chicken lethal dose and mean death time of H242/20(H5N8) group were 10<sup>4.5</sup> EID<sub>50</sub> and 4.3 days, respectively, which indicate less virulent than those of HD1/17(H5N6) (10<sup>3.6</sup> EID<sub>50</sub> and 2.2 days). Whereas, chickens inoculated with H242/20(H5N8) survived longer and had a higher titer of viral shedding than those inoculated with HD1/17(H5N6), which may increase the risk of viral contamination on farms. All ducks infected with either HPAI virus survived without clinical symptoms. In addition, they exhibited a longer virus shedding period and a higher transmission rate, indicating that ducks may play an important role as a silent carrier of both HPAI viruses. These results suggest that the pathogenic characteristics of HPAI viruses in chickens and ducks need to be considered to effectively control HPAI outbreaks in the field. |
| first_indexed | 2024-03-10T06:09:48Z |
| format | Article |
| id | doaj.art-bd9e3af165ca4fb9b19d30e34a226167 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T06:09:48Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-bd9e3af165ca4fb9b19d30e34a2261672023-11-22T20:17:49ZengMDPI AGViruses1999-49152021-09-011310190310.3390/v13101903Pathogenicity of H5N8 High Pathogenicity Avian Influenza Virus in Chickens and Ducks from South Korea in 2020–2021Min-Ji Park0Ra Mi Cha1Soo-Jeong Kye2Yu-Na Lee3Na-Yeong Kim4Yoon-Gi Baek5Gyeong-Beom Heo6Mingeun Sagong7Kwang-Nyeong Lee8Youn-Jeong Lee9Eun-Kyoung Lee10Avian Influenza Research & Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, Gyeongsangbuk-do, KoreaAvian Influenza Research & Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, Gyeongsangbuk-do, KoreaAvian Influenza Research & Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, Gyeongsangbuk-do, KoreaAvian Influenza Research & Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, Gyeongsangbuk-do, KoreaAvian Influenza Research & Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, Gyeongsangbuk-do, KoreaAvian Influenza Research & Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, Gyeongsangbuk-do, KoreaAvian Influenza Research & Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, Gyeongsangbuk-do, KoreaAvian Influenza Research & Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, Gyeongsangbuk-do, KoreaAvian Influenza Research & Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, Gyeongsangbuk-do, KoreaAvian Influenza Research & Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, Gyeongsangbuk-do, KoreaAvian Influenza Research & Diagnostic Division, Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon-si 39660, Gyeongsangbuk-do, KoreaDuring the 2020–2021 winter season, an outbreak of clade 2.3.4.4b H5N8 high pathogenicity avian influenza (HPAI) virus occurred in South Korea. Here, we evaluated the pathogenicity and transmissibility of A/mandarin duck/Korea/H242/2020 (H5N8) (H242/20(H5N8)) first isolated from this outbreak in specific pathogen-free (SPF) chickens and commercial ducks in comparison with those of A/duck/Korea/HD1/2017(H5N6) (HD1/17(H5N6)) from a previous HPAI outbreak in 2017–2018. In chickens, the 50% chicken lethal dose and mean death time of H242/20(H5N8) group were 10<sup>4.5</sup> EID<sub>50</sub> and 4.3 days, respectively, which indicate less virulent than those of HD1/17(H5N6) (10<sup>3.6</sup> EID<sub>50</sub> and 2.2 days). Whereas, chickens inoculated with H242/20(H5N8) survived longer and had a higher titer of viral shedding than those inoculated with HD1/17(H5N6), which may increase the risk of viral contamination on farms. All ducks infected with either HPAI virus survived without clinical symptoms. In addition, they exhibited a longer virus shedding period and a higher transmission rate, indicating that ducks may play an important role as a silent carrier of both HPAI viruses. These results suggest that the pathogenic characteristics of HPAI viruses in chickens and ducks need to be considered to effectively control HPAI outbreaks in the field.https://www.mdpi.com/1999-4915/13/10/1903high pathogenicity avian influenzapathogenicitychickenducks |
| spellingShingle | Min-Ji Park Ra Mi Cha Soo-Jeong Kye Yu-Na Lee Na-Yeong Kim Yoon-Gi Baek Gyeong-Beom Heo Mingeun Sagong Kwang-Nyeong Lee Youn-Jeong Lee Eun-Kyoung Lee Pathogenicity of H5N8 High Pathogenicity Avian Influenza Virus in Chickens and Ducks from South Korea in 2020–2021 Viruses high pathogenicity avian influenza pathogenicity chicken ducks |
| title | Pathogenicity of H5N8 High Pathogenicity Avian Influenza Virus in Chickens and Ducks from South Korea in 2020–2021 |
| title_full | Pathogenicity of H5N8 High Pathogenicity Avian Influenza Virus in Chickens and Ducks from South Korea in 2020–2021 |
| title_fullStr | Pathogenicity of H5N8 High Pathogenicity Avian Influenza Virus in Chickens and Ducks from South Korea in 2020–2021 |
| title_full_unstemmed | Pathogenicity of H5N8 High Pathogenicity Avian Influenza Virus in Chickens and Ducks from South Korea in 2020–2021 |
| title_short | Pathogenicity of H5N8 High Pathogenicity Avian Influenza Virus in Chickens and Ducks from South Korea in 2020–2021 |
| title_sort | pathogenicity of h5n8 high pathogenicity avian influenza virus in chickens and ducks from south korea in 2020 2021 |
| topic | high pathogenicity avian influenza pathogenicity chicken ducks |
| url | https://www.mdpi.com/1999-4915/13/10/1903 |
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