A COMPLETE NMR STUDY OF DOXAZOSIN CHARACTERIZATION
Doxazosin is an important drug used for treating hypertension and prostatic hyperplasia. An enantiomeric mixture (R)/(S) doxazosin mesylate was complete characterized by NMR and additionally FT-IR spectroscopy techniques. Were performed different NMR experiments, such as APT, HSQC, and HMBC in orde...
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| Format: | Article |
| Language: | English |
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Universidade Federal do Rio Grande do Sul
2017-08-01
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| Series: | Drug Analytical Research |
| Online Access: | https://seer.ufrgs.br/index.php/produto&producao/ojs/index.php/dar/article/view/73960 |
| _version_ | 1797311740061417472 |
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| author | Itamar Luís Gonçalves Mariana Maier Gaelzer Gabriel Oliveira de Azambuja Christianne Gazzana Salbego Vera Lucia Eifler-Lima |
| author_facet | Itamar Luís Gonçalves Mariana Maier Gaelzer Gabriel Oliveira de Azambuja Christianne Gazzana Salbego Vera Lucia Eifler-Lima |
| author_sort | Itamar Luís Gonçalves |
| collection | DOAJ |
| description |
Doxazosin is an important drug used for treating hypertension and prostatic hyperplasia. An enantiomeric mixture (R)/(S) doxazosin mesylate was complete characterized by NMR and additionally FT-IR spectroscopy techniques. Were performed different NMR experiments, such as APT, HSQC, and HMBC in order to confirm the NMR signals assignments. All the hydrogens and the most of carbons atoms were assigned.
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| first_indexed | 2024-03-08T02:05:09Z |
| format | Article |
| id | doaj.art-bda146b704ff439b910aee903f427430 |
| institution | Directory Open Access Journal |
| issn | 2527-2616 |
| language | English |
| last_indexed | 2024-03-08T02:05:09Z |
| publishDate | 2017-08-01 |
| publisher | Universidade Federal do Rio Grande do Sul |
| record_format | Article |
| series | Drug Analytical Research |
| spelling | doaj.art-bda146b704ff439b910aee903f4274302024-02-13T18:15:12ZengUniversidade Federal do Rio Grande do SulDrug Analytical Research2527-26162017-08-0111A COMPLETE NMR STUDY OF DOXAZOSIN CHARACTERIZATIONItamar Luís Gonçalves0Mariana Maier Gaelzer1Gabriel Oliveira de Azambuja2Christianne Gazzana Salbego3Vera Lucia Eifler-Lima4Laboratório de Síntese Orgânica Medicinal/LaSOM, Programa de Pós-Graduação em Ciências Farmacêuticas/PPGCF, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre-RS, BrazilPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil,aLaboratório de Síntese Orgânica Medicinal/LaSOM, Programa de Pós-Graduação em Ciências Farmacêuticas/PPGCF, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre-RS, BrazilPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, BrasilLaboratório de Síntese Orgânica Medicinal/LaSOM, Programa de Pós-Graduação em Ciências Farmacêuticas/PPGCF, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre-RS, Brazil Doxazosin is an important drug used for treating hypertension and prostatic hyperplasia. An enantiomeric mixture (R)/(S) doxazosin mesylate was complete characterized by NMR and additionally FT-IR spectroscopy techniques. Were performed different NMR experiments, such as APT, HSQC, and HMBC in order to confirm the NMR signals assignments. All the hydrogens and the most of carbons atoms were assigned. https://seer.ufrgs.br/index.php/produto&producao/ojs/index.php/dar/article/view/73960 |
| spellingShingle | Itamar Luís Gonçalves Mariana Maier Gaelzer Gabriel Oliveira de Azambuja Christianne Gazzana Salbego Vera Lucia Eifler-Lima A COMPLETE NMR STUDY OF DOXAZOSIN CHARACTERIZATION Drug Analytical Research |
| title | A COMPLETE NMR STUDY OF DOXAZOSIN CHARACTERIZATION |
| title_full | A COMPLETE NMR STUDY OF DOXAZOSIN CHARACTERIZATION |
| title_fullStr | A COMPLETE NMR STUDY OF DOXAZOSIN CHARACTERIZATION |
| title_full_unstemmed | A COMPLETE NMR STUDY OF DOXAZOSIN CHARACTERIZATION |
| title_short | A COMPLETE NMR STUDY OF DOXAZOSIN CHARACTERIZATION |
| title_sort | complete nmr study of doxazosin characterization |
| url | https://seer.ufrgs.br/index.php/produto&producao/ojs/index.php/dar/article/view/73960 |
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