Diagnostic Value of Endoscopic Ultrasound after Neoadjuvant Chemotherapy for Gastric Cancer Restaging: A Meta-Analysis of Diagnostic Test
This study aimed to evaluate the diagnostic value of endoscopic ultrasound (EUS) after neoadjuvant therapy (NT) for gastric cancer restaging by meta-analysis. We conducted a systematic search of studies published on PubMed and Web of Science up to 30th August 2021. Assessing the risk of bias in the...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/1/100 |
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| author | Victor Mihai Sacerdotianu Bogdan Silviu Ungureanu Sevastita Iordache Adina Turcu-Stiolica Antonio Facciorusso Stefano Francesco Crinò Adrian Saftoiu |
| author_facet | Victor Mihai Sacerdotianu Bogdan Silviu Ungureanu Sevastita Iordache Adina Turcu-Stiolica Antonio Facciorusso Stefano Francesco Crinò Adrian Saftoiu |
| author_sort | Victor Mihai Sacerdotianu |
| collection | DOAJ |
| description | This study aimed to evaluate the diagnostic value of endoscopic ultrasound (EUS) after neoadjuvant therapy (NT) for gastric cancer restaging by meta-analysis. We conducted a systematic search of studies published on PubMed and Web of Science up to 30th August 2021. Assessing the risk of bias in the included studies was done with the QUADAS-2 tool. We used R and Review Manager 5.4.1 for calculations and statistical analysis. To evaluate the diagnostic value of EUS after NT for gastric cancer restaging, we performed a meta-analysis on six studies, with a total of 283 patients, including true-positive, true-negative, false-positive, and false-negative results for T1-T4, N0. EUS as a diagnostic test for GC patients after chemotherapy has a relatively low DOR for the T2 (3.96) and T4 stages (4.79) and a relatively high partial AUC for the T2 (0.85) and T4 (0.71) stages. Our results reveal that the pooled sensitivity for T stages after chemotherapy is rather low (29–56%), except for the T3 stage (71%). A potential limitation of our study was the small number of included studies, but no significant heterogeneity was found between them. Our meta-analysis concludes that EUS is not recommended or is still under debate for GC restaging after NT. |
| first_indexed | 2024-03-10T01:38:46Z |
| format | Article |
| id | doaj.art-bda188d141d44cef9fc892d90fa2318b |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T01:38:46Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-bda188d141d44cef9fc892d90fa2318b2023-11-23T13:28:13ZengMDPI AGDiagnostics2075-44182022-01-0112110010.3390/diagnostics12010100Diagnostic Value of Endoscopic Ultrasound after Neoadjuvant Chemotherapy for Gastric Cancer Restaging: A Meta-Analysis of Diagnostic TestVictor Mihai Sacerdotianu0Bogdan Silviu Ungureanu1Sevastita Iordache2Adina Turcu-Stiolica3Antonio Facciorusso4Stefano Francesco Crinò5Adrian Saftoiu6Gastroenterology Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaGastroenterology Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaGastroenterology Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaPharmacoeconomics Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaPancreas Center, Gastroenterology Unit, Department of Medicine, University of Verona, 37134 Verona, ItalyPancreas Center, Gastroenterology Unit, Department of Medicine, University of Verona, 37134 Verona, ItalyGastroenterology Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaThis study aimed to evaluate the diagnostic value of endoscopic ultrasound (EUS) after neoadjuvant therapy (NT) for gastric cancer restaging by meta-analysis. We conducted a systematic search of studies published on PubMed and Web of Science up to 30th August 2021. Assessing the risk of bias in the included studies was done with the QUADAS-2 tool. We used R and Review Manager 5.4.1 for calculations and statistical analysis. To evaluate the diagnostic value of EUS after NT for gastric cancer restaging, we performed a meta-analysis on six studies, with a total of 283 patients, including true-positive, true-negative, false-positive, and false-negative results for T1-T4, N0. EUS as a diagnostic test for GC patients after chemotherapy has a relatively low DOR for the T2 (3.96) and T4 stages (4.79) and a relatively high partial AUC for the T2 (0.85) and T4 (0.71) stages. Our results reveal that the pooled sensitivity for T stages after chemotherapy is rather low (29–56%), except for the T3 stage (71%). A potential limitation of our study was the small number of included studies, but no significant heterogeneity was found between them. Our meta-analysis concludes that EUS is not recommended or is still under debate for GC restaging after NT.https://www.mdpi.com/2075-4418/12/1/100endoscopic ultrasoundgastric cancerrestaging |
| spellingShingle | Victor Mihai Sacerdotianu Bogdan Silviu Ungureanu Sevastita Iordache Adina Turcu-Stiolica Antonio Facciorusso Stefano Francesco Crinò Adrian Saftoiu Diagnostic Value of Endoscopic Ultrasound after Neoadjuvant Chemotherapy for Gastric Cancer Restaging: A Meta-Analysis of Diagnostic Test Diagnostics endoscopic ultrasound gastric cancer restaging |
| title | Diagnostic Value of Endoscopic Ultrasound after Neoadjuvant Chemotherapy for Gastric Cancer Restaging: A Meta-Analysis of Diagnostic Test |
| title_full | Diagnostic Value of Endoscopic Ultrasound after Neoadjuvant Chemotherapy for Gastric Cancer Restaging: A Meta-Analysis of Diagnostic Test |
| title_fullStr | Diagnostic Value of Endoscopic Ultrasound after Neoadjuvant Chemotherapy for Gastric Cancer Restaging: A Meta-Analysis of Diagnostic Test |
| title_full_unstemmed | Diagnostic Value of Endoscopic Ultrasound after Neoadjuvant Chemotherapy for Gastric Cancer Restaging: A Meta-Analysis of Diagnostic Test |
| title_short | Diagnostic Value of Endoscopic Ultrasound after Neoadjuvant Chemotherapy for Gastric Cancer Restaging: A Meta-Analysis of Diagnostic Test |
| title_sort | diagnostic value of endoscopic ultrasound after neoadjuvant chemotherapy for gastric cancer restaging a meta analysis of diagnostic test |
| topic | endoscopic ultrasound gastric cancer restaging |
| url | https://www.mdpi.com/2075-4418/12/1/100 |
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