Bacterial Species and Antimicrobial Resistance of Clinical Isolates from Pediatric Patients in Yangon, Myanmar, 2020
Antimicrobial resistance (AMR) is a concern in medical care for children who have high burden of infectious diseases. We investigated the prevalence of bacterial species and their susceptibility to antimicrobials of 1019 clinical isolates from pediatric patients in a tertiary-care hospital in Yangon...
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MDPI AG
2022-01-01
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| Online Access: | https://www.mdpi.com/2036-7449/14/1/4 |
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| author | Thida San Meiji Soe Aung Nilar San Myat Myint Zu Aung Win Lei Yi Mon Thin Ei Thazin Nobumichi Kobayashi |
| author_facet | Thida San Meiji Soe Aung Nilar San Myat Myint Zu Aung Win Lei Yi Mon Thin Ei Thazin Nobumichi Kobayashi |
| author_sort | Thida San |
| collection | DOAJ |
| description | Antimicrobial resistance (AMR) is a concern in medical care for children who have high burden of infectious diseases. We investigated the prevalence of bacterial species and their susceptibility to antimicrobials of 1019 clinical isolates from pediatric patients in a tertiary-care hospital in Yangon, Myanmar for one-year period (2020). The most frequently recovered species was <i>Escherichia coli</i>, followed by <i>Klebsiella pneumoniae</i> and <i>Staphylococcus aureus</i>, all of which accounted for 43% of clinical isolates, while 25% of isolates comprised non-fermenter, including <i>Pseudomonas</i> sp. and <i>Acinetobacter</i> sp. Phenotypically determined ESBL (extended-spectrum beta-lactamase)-positive rates in <i>E. coli</i>, <i>K. pneumoniae</i>, and <i>Enterobacter</i> sp. were 82%, 88%, and 65%, respectively. High rates of multiple drug resistance were noted for <i>E. coli</i> (84%), <i>K. pneumoniae</i> (81%), and <i>Acinetobacter</i> sp. (65%), associated with carbapenem resistance in 48%, 42%, and 59% of isolates, respectively. In contrast, <i>S. aureus</i> isolates exhibited low resistance rates (<30%) to most of antimicrobials, with 22% being resistant to oxacillin/cefoxitin. Fluoroquinolone resistance was found in most of bacterial species with different prevalence rates. The present study revealed the current status on prevalence of bacterial species causing infections in pediatric patients in Myanmar, highlighting the significance to monitor AMR among children. |
| first_indexed | 2024-03-09T21:47:22Z |
| format | Article |
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| issn | 2036-7449 |
| language | English |
| last_indexed | 2024-03-09T21:47:22Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Infectious Disease Reports |
| spelling | doaj.art-bda5710dd7d146d382335eef95a4de042023-11-23T20:13:58ZengMDPI AGInfectious Disease Reports2036-74492022-01-01141263210.3390/idr14010004Bacterial Species and Antimicrobial Resistance of Clinical Isolates from Pediatric Patients in Yangon, Myanmar, 2020Thida San0Meiji Soe Aung1Nilar San2Myat Myint Zu Aung3Win Lei Yi Mon4Thin Ei Thazin5Nobumichi Kobayashi6Department of Clinical Laboratory, Yangon Children’s Hospital, Yangon 11191, MyanmarDepartment of Hygiene, School of Medicine, Sapporo Medical University, Sapporo 060-8556, JapanDepartment of Microbiology, University of Medicine 2, Yangon 11031, MyanmarDepartment of Microbiology, University of Medicine 1, Yangon 11131, MyanmarDepartment of Clinical Laboratory, Yangon General Hospital, Yangon 11131, MyanmarDepartment of Clinical Laboratory, Yangon Children’s Hospital, Yangon 11191, MyanmarDepartment of Hygiene, School of Medicine, Sapporo Medical University, Sapporo 060-8556, JapanAntimicrobial resistance (AMR) is a concern in medical care for children who have high burden of infectious diseases. We investigated the prevalence of bacterial species and their susceptibility to antimicrobials of 1019 clinical isolates from pediatric patients in a tertiary-care hospital in Yangon, Myanmar for one-year period (2020). The most frequently recovered species was <i>Escherichia coli</i>, followed by <i>Klebsiella pneumoniae</i> and <i>Staphylococcus aureus</i>, all of which accounted for 43% of clinical isolates, while 25% of isolates comprised non-fermenter, including <i>Pseudomonas</i> sp. and <i>Acinetobacter</i> sp. Phenotypically determined ESBL (extended-spectrum beta-lactamase)-positive rates in <i>E. coli</i>, <i>K. pneumoniae</i>, and <i>Enterobacter</i> sp. were 82%, 88%, and 65%, respectively. High rates of multiple drug resistance were noted for <i>E. coli</i> (84%), <i>K. pneumoniae</i> (81%), and <i>Acinetobacter</i> sp. (65%), associated with carbapenem resistance in 48%, 42%, and 59% of isolates, respectively. In contrast, <i>S. aureus</i> isolates exhibited low resistance rates (<30%) to most of antimicrobials, with 22% being resistant to oxacillin/cefoxitin. Fluoroquinolone resistance was found in most of bacterial species with different prevalence rates. The present study revealed the current status on prevalence of bacterial species causing infections in pediatric patients in Myanmar, highlighting the significance to monitor AMR among children.https://www.mdpi.com/2036-7449/14/1/4childrenantimicrobial resistance<i>Escherichia coli</i><i>Klebsiella pneumoniae</i>MRSA<i>Enterococcus</i> |
| spellingShingle | Thida San Meiji Soe Aung Nilar San Myat Myint Zu Aung Win Lei Yi Mon Thin Ei Thazin Nobumichi Kobayashi Bacterial Species and Antimicrobial Resistance of Clinical Isolates from Pediatric Patients in Yangon, Myanmar, 2020 Infectious Disease Reports children antimicrobial resistance <i>Escherichia coli</i> <i>Klebsiella pneumoniae</i> MRSA <i>Enterococcus</i> |
| title | Bacterial Species and Antimicrobial Resistance of Clinical Isolates from Pediatric Patients in Yangon, Myanmar, 2020 |
| title_full | Bacterial Species and Antimicrobial Resistance of Clinical Isolates from Pediatric Patients in Yangon, Myanmar, 2020 |
| title_fullStr | Bacterial Species and Antimicrobial Resistance of Clinical Isolates from Pediatric Patients in Yangon, Myanmar, 2020 |
| title_full_unstemmed | Bacterial Species and Antimicrobial Resistance of Clinical Isolates from Pediatric Patients in Yangon, Myanmar, 2020 |
| title_short | Bacterial Species and Antimicrobial Resistance of Clinical Isolates from Pediatric Patients in Yangon, Myanmar, 2020 |
| title_sort | bacterial species and antimicrobial resistance of clinical isolates from pediatric patients in yangon myanmar 2020 |
| topic | children antimicrobial resistance <i>Escherichia coli</i> <i>Klebsiella pneumoniae</i> MRSA <i>Enterococcus</i> |
| url | https://www.mdpi.com/2036-7449/14/1/4 |
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