Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma
Astrocytes play important roles in neuroinflammatory diseases. Here the authors characterize human glioblastoma-associated astrocytes by gene expression and demonstrate their immunosuppressive role promoted by interactions with tumor and microglia cells in an organotypic model.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10493-6 |
| _version_ | 1818992721824579584 |
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| author | Dieter Henrik Heiland Vidhya M. Ravi Simon P. Behringer Jan Hendrik Frenking Julian Wurm Kevin Joseph Nicklas W. C. Garrelfs Jakob Strähle Sabrina Heynckes Jürgen Grauvogel Pamela Franco Irina Mader Matthias Schneider Anna-Laura Potthoff Daniel Delev Ulrich G. Hofmann Christian Fung Jürgen Beck Roman Sankowski Marco Prinz Oliver Schnell |
| author_facet | Dieter Henrik Heiland Vidhya M. Ravi Simon P. Behringer Jan Hendrik Frenking Julian Wurm Kevin Joseph Nicklas W. C. Garrelfs Jakob Strähle Sabrina Heynckes Jürgen Grauvogel Pamela Franco Irina Mader Matthias Schneider Anna-Laura Potthoff Daniel Delev Ulrich G. Hofmann Christian Fung Jürgen Beck Roman Sankowski Marco Prinz Oliver Schnell |
| author_sort | Dieter Henrik Heiland |
| collection | DOAJ |
| description | Astrocytes play important roles in neuroinflammatory diseases. Here the authors characterize human glioblastoma-associated astrocytes by gene expression and demonstrate their immunosuppressive role promoted by interactions with tumor and microglia cells in an organotypic model. |
| first_indexed | 2024-12-20T20:30:40Z |
| format | Article |
| id | doaj.art-bda58627bc774fe381635dc078c37616 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:30:40Z |
| publishDate | 2019-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bda58627bc774fe381635dc078c376162022-12-21T19:27:22ZengNature PortfolioNature Communications2041-17232019-06-0110111210.1038/s41467-019-10493-6Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastomaDieter Henrik Heiland0Vidhya M. Ravi1Simon P. Behringer2Jan Hendrik Frenking3Julian Wurm4Kevin Joseph5Nicklas W. C. Garrelfs6Jakob Strähle7Sabrina Heynckes8Jürgen Grauvogel9Pamela Franco10Irina Mader11Matthias Schneider12Anna-Laura Potthoff13Daniel Delev14Ulrich G. Hofmann15Christian Fung16Jürgen Beck17Roman Sankowski18Marco Prinz19Oliver Schnell20Translational NeuroOncology Research Group, Medical Center, University of FreiburgDepartment of Neurosurgery, Medical Center, University of FreiburgTranslational NeuroOncology Research Group, Medical Center, University of FreiburgTranslational NeuroOncology Research Group, Medical Center, University of FreiburgTranslational NeuroOncology Research Group, Medical Center, University of FreiburgDepartment of Neurosurgery, Medical Center, University of FreiburgTranslational NeuroOncology Research Group, Medical Center, University of FreiburgDepartment of Neurosurgery, Medical Center, University of FreiburgTranslational NeuroOncology Research Group, Medical Center, University of FreiburgDepartment of Neurosurgery, Medical Center, University of FreiburgTranslational NeuroOncology Research Group, Medical Center, University of FreiburgDepartment of Neuroradiology, Medical Center, University of FreiburgDepartment of Neurosurgery, University of BonnDepartment of Neurosurgery, University of BonnDepartment of Neurosurgery, University of AachenDepartment of Neurosurgery, Medical Center, University of FreiburgDepartment of Neurosurgery, Medical Center, University of FreiburgDepartment of Neurosurgery, Medical Center, University of FreiburgFaculty of Medicine, Freiburg UniversityFaculty of Medicine, Freiburg UniversityTranslational NeuroOncology Research Group, Medical Center, University of FreiburgAstrocytes play important roles in neuroinflammatory diseases. Here the authors characterize human glioblastoma-associated astrocytes by gene expression and demonstrate their immunosuppressive role promoted by interactions with tumor and microglia cells in an organotypic model.https://doi.org/10.1038/s41467-019-10493-6 |
| spellingShingle | Dieter Henrik Heiland Vidhya M. Ravi Simon P. Behringer Jan Hendrik Frenking Julian Wurm Kevin Joseph Nicklas W. C. Garrelfs Jakob Strähle Sabrina Heynckes Jürgen Grauvogel Pamela Franco Irina Mader Matthias Schneider Anna-Laura Potthoff Daniel Delev Ulrich G. Hofmann Christian Fung Jürgen Beck Roman Sankowski Marco Prinz Oliver Schnell Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma Nature Communications |
| title | Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma |
| title_full | Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma |
| title_fullStr | Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma |
| title_full_unstemmed | Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma |
| title_short | Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma |
| title_sort | tumor associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma |
| url | https://doi.org/10.1038/s41467-019-10493-6 |
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