Downregulated expression of peroxiredoxin 4 in granulosa cells from polycystic ovary syndrome.
Peroxiredoxin 4 (PRDX4), a member of Peroxiredoxin (PRDX) family, is a typical 2-Cys PRDX. PRDX4 monitors the oxidative burden within cellular compartment and reduces hydrogen peroxide and alkyl hydroperoxide related to oxidative stress and apoptosis. Antioxidant, like PRDX4, may promote follicle de...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3789707?pdf=render |
| _version_ | 1818502802551341056 |
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| author | Yan Meng Yi Qian Li Gao Ling-Bo Cai Yu-Gui Cui Jia-Yin Liu |
| author_facet | Yan Meng Yi Qian Li Gao Ling-Bo Cai Yu-Gui Cui Jia-Yin Liu |
| author_sort | Yan Meng |
| collection | DOAJ |
| description | Peroxiredoxin 4 (PRDX4), a member of Peroxiredoxin (PRDX) family, is a typical 2-Cys PRDX. PRDX4 monitors the oxidative burden within cellular compartment and reduces hydrogen peroxide and alkyl hydroperoxide related to oxidative stress and apoptosis. Antioxidant, like PRDX4, may promote follicle development and participate in the pathophysiology of PCOS. In our previous study, we found that PRDX4 was expressed in mice oocyte cumulus oophorus complex, and that PRDX4 could be associated with follicle development. In this study, we explored the expression of PRDX4 in human follicles and possible role of PRDX4 in PCOS pathophysiology. Our data showed that PRDX4 was mainly expressed in granulosa cells in human ovaries. When compared to control group, both PRDX4 mRNA level and protein level decreased in PCOS group. The lowered levels of PRDX4 may relate to oxidative stress in the pathophysiologic progress of PCOS. Furthermore, expression of PRDX4 in the granulosa cells of in vivo or in vitro matured follicles was higher than that in immatured follicles, which suggested that PRDX4 may have a close relationship with follicular development. Altogether, our findings may provide new clues of the pathophysiologic mechanism of PCOS and potential therapeutic strategy using antioxidant, like PRDX4. |
| first_indexed | 2024-12-10T21:15:18Z |
| format | Article |
| id | doaj.art-bda6ff56515e4ff29fc3975d76bd74e3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T21:15:18Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-bda6ff56515e4ff29fc3975d76bd74e32022-12-22T01:33:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7646010.1371/journal.pone.0076460Downregulated expression of peroxiredoxin 4 in granulosa cells from polycystic ovary syndrome.Yan MengYi QianLi GaoLing-Bo CaiYu-Gui CuiJia-Yin LiuPeroxiredoxin 4 (PRDX4), a member of Peroxiredoxin (PRDX) family, is a typical 2-Cys PRDX. PRDX4 monitors the oxidative burden within cellular compartment and reduces hydrogen peroxide and alkyl hydroperoxide related to oxidative stress and apoptosis. Antioxidant, like PRDX4, may promote follicle development and participate in the pathophysiology of PCOS. In our previous study, we found that PRDX4 was expressed in mice oocyte cumulus oophorus complex, and that PRDX4 could be associated with follicle development. In this study, we explored the expression of PRDX4 in human follicles and possible role of PRDX4 in PCOS pathophysiology. Our data showed that PRDX4 was mainly expressed in granulosa cells in human ovaries. When compared to control group, both PRDX4 mRNA level and protein level decreased in PCOS group. The lowered levels of PRDX4 may relate to oxidative stress in the pathophysiologic progress of PCOS. Furthermore, expression of PRDX4 in the granulosa cells of in vivo or in vitro matured follicles was higher than that in immatured follicles, which suggested that PRDX4 may have a close relationship with follicular development. Altogether, our findings may provide new clues of the pathophysiologic mechanism of PCOS and potential therapeutic strategy using antioxidant, like PRDX4.http://europepmc.org/articles/PMC3789707?pdf=render |
| spellingShingle | Yan Meng Yi Qian Li Gao Ling-Bo Cai Yu-Gui Cui Jia-Yin Liu Downregulated expression of peroxiredoxin 4 in granulosa cells from polycystic ovary syndrome. PLoS ONE |
| title | Downregulated expression of peroxiredoxin 4 in granulosa cells from polycystic ovary syndrome. |
| title_full | Downregulated expression of peroxiredoxin 4 in granulosa cells from polycystic ovary syndrome. |
| title_fullStr | Downregulated expression of peroxiredoxin 4 in granulosa cells from polycystic ovary syndrome. |
| title_full_unstemmed | Downregulated expression of peroxiredoxin 4 in granulosa cells from polycystic ovary syndrome. |
| title_short | Downregulated expression of peroxiredoxin 4 in granulosa cells from polycystic ovary syndrome. |
| title_sort | downregulated expression of peroxiredoxin 4 in granulosa cells from polycystic ovary syndrome |
| url | http://europepmc.org/articles/PMC3789707?pdf=render |
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