The taming of PARP1 and its impact on NAD+ metabolism

The taming of PARP1 and its impact on NAD+ metabolism

Background: Poly-ADP-ribose polymerases (PARPs) are key mediators of cellular stress response. They are intimately linked to cellular metabolism through the consumption of NAD+. PARP1/ARTD1 in the nucleus is the major NAD+ consuming activity and plays a key role in maintaining genomic integrity. Sco...

Full description

Bibliographic Details
Main Authors: Sarah Hurtado-Bagès, Gunnar Knobloch, Andreas G. Ladurner, Marcus Buschbeck
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Molecular Metabolism
Subjects:
PARP1
NAD+
Epigenetics
MacroH2A
Metabolism
Homeostasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820300223

Similar Items

Similar Items