Interactions between Gut Microbiota and Oral Antihyperglycemic Drugs: A Systematic Review
The intestinal microbiota refers to the collection of microorganisms that exist in the human gut. It has been said that bacteria influence the development of metabolic diseases, such as diabetes mellitus, as they have roles in immunomodulation, protection against pathogens, blood vessel growth, repa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/6/3540 |
| _version_ | 1797240707967090688 |
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| author | Nicoleta Mihaela Mindrescu Cristian Guja Viorel Jinga Sorina Ispas Antoanela Curici Andreea Nelson Twakor Anca Mihaela Pantea Stoian |
| author_facet | Nicoleta Mihaela Mindrescu Cristian Guja Viorel Jinga Sorina Ispas Antoanela Curici Andreea Nelson Twakor Anca Mihaela Pantea Stoian |
| author_sort | Nicoleta Mihaela Mindrescu |
| collection | DOAJ |
| description | The intestinal microbiota refers to the collection of microorganisms that exist in the human gut. It has been said that bacteria influence the development of metabolic diseases, such as diabetes mellitus, as they have roles in immunomodulation, protection against pathogens, blood vessel growth, repairing the intestinal wall, and the development of the neurological system. In this review, we look at the latest research regarding interactions between gut microbiota and oral antihyperglycemic drugs and we present data suggesting that the microbiome may help counteract the reduced glucose tolerance and insulin resistance associated with metabolic disorders. We found that antidiabetic drugs can have significant impacts on gut microbiota composition and function, potentially influencing both the efficacy and side effects of these medications. Additionally, we discovered that microbial-based therapeutics, including probiotics, prebiotics, and postbiotics, and fecal microbiota can be considered when discussing preventive measures and personalized treatment options for type 2 diabetes mellitus. Understanding how antidiabetic drugs modulate gut microbiota composition and function is essential for optimizing their therapeutic efficacy and minimizing potential adverse effects. The relationship between the gut microbiota and glycemic agents, not fully understood, is currently the subject of increasing research and discussion. It has been proven that the microbiome can impact the effectiveness of the medications, but further research in this field may uncover novel therapeutic strategies for diabetes and other metabolic disorders by targeting the gut microbiota. |
| first_indexed | 2024-04-24T18:11:43Z |
| format | Article |
| id | doaj.art-bdafb95288584aa1b1891bf9c291ce0f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-24T18:11:43Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-bdafb95288584aa1b1891bf9c291ce0f2024-03-27T13:46:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01256354010.3390/ijms25063540Interactions between Gut Microbiota and Oral Antihyperglycemic Drugs: A Systematic ReviewNicoleta Mihaela Mindrescu0Cristian Guja1Viorel Jinga2Sorina Ispas3Antoanela Curici4Andreea Nelson Twakor5Anca Mihaela Pantea Stoian6Department of Diabetes, Nutrition and Metabolic Diseases, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Diabetes, Nutrition and Metabolic Diseases, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Diabetes, Nutrition and Metabolic Diseases, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Anatomy, Faculty of General Medicine, “Ovidius” University, 900470 Constanta, RomaniaDepartment of Cellular and Molecular Biology, and Histology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Internal Medicine, Emergency County Hospital, 900591 Constanta, RomaniaDepartment of Diabetes, Nutrition and Metabolic Diseases, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaThe intestinal microbiota refers to the collection of microorganisms that exist in the human gut. It has been said that bacteria influence the development of metabolic diseases, such as diabetes mellitus, as they have roles in immunomodulation, protection against pathogens, blood vessel growth, repairing the intestinal wall, and the development of the neurological system. In this review, we look at the latest research regarding interactions between gut microbiota and oral antihyperglycemic drugs and we present data suggesting that the microbiome may help counteract the reduced glucose tolerance and insulin resistance associated with metabolic disorders. We found that antidiabetic drugs can have significant impacts on gut microbiota composition and function, potentially influencing both the efficacy and side effects of these medications. Additionally, we discovered that microbial-based therapeutics, including probiotics, prebiotics, and postbiotics, and fecal microbiota can be considered when discussing preventive measures and personalized treatment options for type 2 diabetes mellitus. Understanding how antidiabetic drugs modulate gut microbiota composition and function is essential for optimizing their therapeutic efficacy and minimizing potential adverse effects. The relationship between the gut microbiota and glycemic agents, not fully understood, is currently the subject of increasing research and discussion. It has been proven that the microbiome can impact the effectiveness of the medications, but further research in this field may uncover novel therapeutic strategies for diabetes and other metabolic disorders by targeting the gut microbiota.https://www.mdpi.com/1422-0067/25/6/3540oral antihyperglycemic drugsgut microbiotadiabetes mellitus |
| spellingShingle | Nicoleta Mihaela Mindrescu Cristian Guja Viorel Jinga Sorina Ispas Antoanela Curici Andreea Nelson Twakor Anca Mihaela Pantea Stoian Interactions between Gut Microbiota and Oral Antihyperglycemic Drugs: A Systematic Review International Journal of Molecular Sciences oral antihyperglycemic drugs gut microbiota diabetes mellitus |
| title | Interactions between Gut Microbiota and Oral Antihyperglycemic Drugs: A Systematic Review |
| title_full | Interactions between Gut Microbiota and Oral Antihyperglycemic Drugs: A Systematic Review |
| title_fullStr | Interactions between Gut Microbiota and Oral Antihyperglycemic Drugs: A Systematic Review |
| title_full_unstemmed | Interactions between Gut Microbiota and Oral Antihyperglycemic Drugs: A Systematic Review |
| title_short | Interactions between Gut Microbiota and Oral Antihyperglycemic Drugs: A Systematic Review |
| title_sort | interactions between gut microbiota and oral antihyperglycemic drugs a systematic review |
| topic | oral antihyperglycemic drugs gut microbiota diabetes mellitus |
| url | https://www.mdpi.com/1422-0067/25/6/3540 |
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