Notch signaling regulates the lifespan of vascular endothelial cells via a p16-dependent pathway.

Notch signaling regulates the lifespan of vascular endothelial cells via a p16-dependent pathway.

Evolutionarily conserved Notch signaling controls cell fate determination and differentiation during development, and is also essential for neovascularization in adults. Although recent studies suggest that the Notch pathway is associated with age-related conditions, it remains unclear whether Notch...

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Bibliographic Details
Main Authors: Yohko Yoshida, Yuka Hayashi, Masayoshi Suda, Kaoru Tateno, Sho Okada, Junji Moriya, Masataka Yokoyama, Aika Nojima, Masakatsu Yamashita, Yoshio Kobayashi, Ippei Shimizu, Tohru Minamino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4065107?pdf=render

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