Cachexia index as a prognostic predictor after resection of pancreatic ductal adenocarcinoma
Abstract Aim This study was performed to investigate the relationship between the preoperative cachexia index (CXI) and long‐term outcomes in patients who have undergone radical resection of pancreatic ductal adenocarcinoma (PDAC). Methods In total, 144 patients who underwent pancreatic resection fo...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Annals of Gastroenterological Surgery |
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| Online Access: | https://doi.org/10.1002/ags3.12686 |
| _version_ | 1827773008852287488 |
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| author | Tomonari Shimagaki Keishi Sugimachi Yohei Mano Emi Onishi Tomohiro Iguchi Yuichiro Nakashima Masahiko Sugiyama Manabu Yamamoto Masaru Morita Yasushi Toh |
| author_facet | Tomonari Shimagaki Keishi Sugimachi Yohei Mano Emi Onishi Tomohiro Iguchi Yuichiro Nakashima Masahiko Sugiyama Manabu Yamamoto Masaru Morita Yasushi Toh |
| author_sort | Tomonari Shimagaki |
| collection | DOAJ |
| description | Abstract Aim This study was performed to investigate the relationship between the preoperative cachexia index (CXI) and long‐term outcomes in patients who have undergone radical resection of pancreatic ductal adenocarcinoma (PDAC). Methods In total, 144 patients who underwent pancreatic resection for treatment of PDAC were retrospectively analyzed. The relationship between the CXI and the patients' long‐term outcomes after PDAC resection was investigated. The CXI was calculated based on the preoperative skeletal muscle index, serum albumin level, and neutrophil‐to‐lymphocyte ratio. After propensity‐score matching, we compared clinicopathological features and outcomes. Results The multivariate analysis showed that lymph node metastasis (hazard ratio [HR], 1.93; 95% confidence interval [CI], 1.16–3.23; P = 0.0118), R1 resection (HR, 57.20; 95% CI, 9.39–348.30; P < 0.0001), and a low CXI (HR, 2.10; 95% CI, 1.27–3.46; P = 0.0038) were independent and significant predictors of disease‐free survival (DFS) after PDAC resection. Moreover, a low CXI (HR, 3.14; 95% CI, 1.71–5.75; P = 0.0002) was an independent and significant predictor of overall survival (OS) after PDAC resection. After propensity‐score matching, the low CXI group had a significantly worse prognosis than the high CXI group for both DFS and OS. Conclusion The CXI can be a useful prognostic factor for DFS and OS after pancreatic resection for treatment of PDAC. |
| first_indexed | 2024-03-11T13:15:58Z |
| format | Article |
| id | doaj.art-bdb21f7ea9fb4d449ac25ad67b67f744 |
| institution | Directory Open Access Journal |
| issn | 2475-0328 |
| language | English |
| last_indexed | 2024-03-11T13:15:58Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Gastroenterological Surgery |
| spelling | doaj.art-bdb21f7ea9fb4d449ac25ad67b67f7442023-11-03T13:04:50ZengWileyAnnals of Gastroenterological Surgery2475-03282023-11-017697798610.1002/ags3.12686Cachexia index as a prognostic predictor after resection of pancreatic ductal adenocarcinomaTomonari Shimagaki0Keishi Sugimachi1Yohei Mano2Emi Onishi3Tomohiro Iguchi4Yuichiro Nakashima5Masahiko Sugiyama6Manabu Yamamoto7Masaru Morita8Yasushi Toh9Department of Hepatobiliary and Pancreatic Surgery National Hospital Organization Kyushu Cancer Center Fukuoka JapanDepartment of Hepatobiliary and Pancreatic Surgery National Hospital Organization Kyushu Cancer Center Fukuoka JapanDepartment of Hepatobiliary and Pancreatic Surgery National Hospital Organization Kyushu Cancer Center Fukuoka JapanDepartment of Hepatobiliary and Pancreatic Surgery National Hospital Organization Kyushu Cancer Center Fukuoka JapanDepartment of Hepatobiliary and Pancreatic Surgery National Hospital Organization Kyushu Cancer Center Fukuoka JapanDepartment of Gastroenterological Surgery National Hospital Organization Kyushu Cancer Center Fukuoka JapanDepartment of Gastroenterological Surgery National Hospital Organization Kyushu Cancer Center Fukuoka JapanDepartment of Gastroenterological Surgery National Hospital Organization Kyushu Cancer Center Fukuoka JapanDepartment of Gastroenterological Surgery National Hospital Organization Kyushu Cancer Center Fukuoka JapanDepartment of Gastroenterological Surgery National Hospital Organization Kyushu Cancer Center Fukuoka JapanAbstract Aim This study was performed to investigate the relationship between the preoperative cachexia index (CXI) and long‐term outcomes in patients who have undergone radical resection of pancreatic ductal adenocarcinoma (PDAC). Methods In total, 144 patients who underwent pancreatic resection for treatment of PDAC were retrospectively analyzed. The relationship between the CXI and the patients' long‐term outcomes after PDAC resection was investigated. The CXI was calculated based on the preoperative skeletal muscle index, serum albumin level, and neutrophil‐to‐lymphocyte ratio. After propensity‐score matching, we compared clinicopathological features and outcomes. Results The multivariate analysis showed that lymph node metastasis (hazard ratio [HR], 1.93; 95% confidence interval [CI], 1.16–3.23; P = 0.0118), R1 resection (HR, 57.20; 95% CI, 9.39–348.30; P < 0.0001), and a low CXI (HR, 2.10; 95% CI, 1.27–3.46; P = 0.0038) were independent and significant predictors of disease‐free survival (DFS) after PDAC resection. Moreover, a low CXI (HR, 3.14; 95% CI, 1.71–5.75; P = 0.0002) was an independent and significant predictor of overall survival (OS) after PDAC resection. After propensity‐score matching, the low CXI group had a significantly worse prognosis than the high CXI group for both DFS and OS. Conclusion The CXI can be a useful prognostic factor for DFS and OS after pancreatic resection for treatment of PDAC.https://doi.org/10.1002/ags3.12686cachexia indexpancreatic ductal adenocarcinomapancreatic resection |
| spellingShingle | Tomonari Shimagaki Keishi Sugimachi Yohei Mano Emi Onishi Tomohiro Iguchi Yuichiro Nakashima Masahiko Sugiyama Manabu Yamamoto Masaru Morita Yasushi Toh Cachexia index as a prognostic predictor after resection of pancreatic ductal adenocarcinoma Annals of Gastroenterological Surgery cachexia index pancreatic ductal adenocarcinoma pancreatic resection |
| title | Cachexia index as a prognostic predictor after resection of pancreatic ductal adenocarcinoma |
| title_full | Cachexia index as a prognostic predictor after resection of pancreatic ductal adenocarcinoma |
| title_fullStr | Cachexia index as a prognostic predictor after resection of pancreatic ductal adenocarcinoma |
| title_full_unstemmed | Cachexia index as a prognostic predictor after resection of pancreatic ductal adenocarcinoma |
| title_short | Cachexia index as a prognostic predictor after resection of pancreatic ductal adenocarcinoma |
| title_sort | cachexia index as a prognostic predictor after resection of pancreatic ductal adenocarcinoma |
| topic | cachexia index pancreatic ductal adenocarcinoma pancreatic resection |
| url | https://doi.org/10.1002/ags3.12686 |
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