No difference in risk of hospitalization between reported cases of the SARS-CoV-2 Delta variant and Alpha variant in Norway
ABSTRACT: Objectives: To estimate the risk of hospitalization among reported cases of the Delta variant of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) compared with the Alpha variant in Norway, and the risk of hospitalization by vaccination status. Methods: A cohort study was condu...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-02-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971221012182 |
| _version_ | 1818366553920372736 |
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| author | Lamprini Veneti Beatriz Valcarcel Salamanca Elina Seppälä Jostein Starrfelt Margrethe Larsdatter Storm Karoline Bragstad Olav Hungnes Håkon Bøås Reidar Kvåle Line Vold Karin Nygård Eirik Alnes Buanes Robert Whittaker |
| author_facet | Lamprini Veneti Beatriz Valcarcel Salamanca Elina Seppälä Jostein Starrfelt Margrethe Larsdatter Storm Karoline Bragstad Olav Hungnes Håkon Bøås Reidar Kvåle Line Vold Karin Nygård Eirik Alnes Buanes Robert Whittaker |
| author_sort | Lamprini Veneti |
| collection | DOAJ |
| description | ABSTRACT: Objectives: To estimate the risk of hospitalization among reported cases of the Delta variant of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) compared with the Alpha variant in Norway, and the risk of hospitalization by vaccination status. Methods: A cohort study was conducted on laboratory-confirmed cases of SARS-CoV-2 in Norway, diagnosed between 3 May and 15 August 2021. Adjusted risk ratios (aRR) with 95% confidence intervals (CI) were calculated using multi-variable log-binomial regression, accounting for variant, vaccination status, demographic characteristics, week of sampling and underlying comorbidities. Results: In total, 7977 cases of the Delta variant and 12,078 cases of the Alpha variant were included in this study. Overall, 347 (1.7%) cases were hospitalized. The aRR of hospitalization for the Delta variant compared with the Alpha variant was 0.97 (95% CI 0.76–1.23). Partially vaccinated cases had a 72% reduced risk of hospitalization (95% CI 59–82%), and fully vaccinated cases had a 76% reduced risk of hospitalization (95% CI 61–85%) compared with unvaccinated cases. Conclusions: No difference was found between the risk of hospitalization for Delta cases and Alpha cases in Norway. The results of this study support the notion that partially and fully vaccinated cases are highly protected against hospitalization with coronavirus disease 2019. |
| first_indexed | 2024-12-13T22:38:00Z |
| format | Article |
| id | doaj.art-bdb300a680ac4d0da8526edb1236b3b9 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-13T22:38:00Z |
| publishDate | 2022-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-bdb300a680ac4d0da8526edb1236b3b92022-12-21T23:28:56ZengElsevierInternational Journal of Infectious Diseases1201-97122022-02-01115178184No difference in risk of hospitalization between reported cases of the SARS-CoV-2 Delta variant and Alpha variant in NorwayLamprini Veneti0Beatriz Valcarcel Salamanca1Elina Seppälä2Jostein Starrfelt3Margrethe Larsdatter Storm4Karoline Bragstad5Olav Hungnes6Håkon Bøås7Reidar Kvåle8Line Vold9Karin Nygård10Eirik Alnes Buanes11Robert Whittaker12Department of Infection Control and Preparedness, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Method Development and Analytics, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Infection Control and Vaccines, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Infection Control and Preparedness, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Infectious Disease Registries, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Virology, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Virology, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Infection Control and Preparedness, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, NorwayDepartment of Infection Control and Preparedness, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Infection Control and Preparedness, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway; Norwegian Intensive Care and Pandemic Registry, Haukeland University Hospital, Bergen, NorwayDepartment of Infection Control and Vaccines, Norwegian Institute of Public Health, Oslo, Norway; Corresponding author. Address: Norwegian Institute of Public Health, Lovisenberggata 8, 0456 Oslo, Norway. Tel.: +47 21 07 63 93.ABSTRACT: Objectives: To estimate the risk of hospitalization among reported cases of the Delta variant of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) compared with the Alpha variant in Norway, and the risk of hospitalization by vaccination status. Methods: A cohort study was conducted on laboratory-confirmed cases of SARS-CoV-2 in Norway, diagnosed between 3 May and 15 August 2021. Adjusted risk ratios (aRR) with 95% confidence intervals (CI) were calculated using multi-variable log-binomial regression, accounting for variant, vaccination status, demographic characteristics, week of sampling and underlying comorbidities. Results: In total, 7977 cases of the Delta variant and 12,078 cases of the Alpha variant were included in this study. Overall, 347 (1.7%) cases were hospitalized. The aRR of hospitalization for the Delta variant compared with the Alpha variant was 0.97 (95% CI 0.76–1.23). Partially vaccinated cases had a 72% reduced risk of hospitalization (95% CI 59–82%), and fully vaccinated cases had a 76% reduced risk of hospitalization (95% CI 61–85%) compared with unvaccinated cases. Conclusions: No difference was found between the risk of hospitalization for Delta cases and Alpha cases in Norway. The results of this study support the notion that partially and fully vaccinated cases are highly protected against hospitalization with coronavirus disease 2019.http://www.sciencedirect.com/science/article/pii/S1201971221012182NorwaySARS-CoV-2HospitalizationVariants of concernDeltaAlpha |
| spellingShingle | Lamprini Veneti Beatriz Valcarcel Salamanca Elina Seppälä Jostein Starrfelt Margrethe Larsdatter Storm Karoline Bragstad Olav Hungnes Håkon Bøås Reidar Kvåle Line Vold Karin Nygård Eirik Alnes Buanes Robert Whittaker No difference in risk of hospitalization between reported cases of the SARS-CoV-2 Delta variant and Alpha variant in Norway International Journal of Infectious Diseases Norway SARS-CoV-2 Hospitalization Variants of concern Delta Alpha |
| title | No difference in risk of hospitalization between reported cases of the SARS-CoV-2 Delta variant and Alpha variant in Norway |
| title_full | No difference in risk of hospitalization between reported cases of the SARS-CoV-2 Delta variant and Alpha variant in Norway |
| title_fullStr | No difference in risk of hospitalization between reported cases of the SARS-CoV-2 Delta variant and Alpha variant in Norway |
| title_full_unstemmed | No difference in risk of hospitalization between reported cases of the SARS-CoV-2 Delta variant and Alpha variant in Norway |
| title_short | No difference in risk of hospitalization between reported cases of the SARS-CoV-2 Delta variant and Alpha variant in Norway |
| title_sort | no difference in risk of hospitalization between reported cases of the sars cov 2 delta variant and alpha variant in norway |
| topic | Norway SARS-CoV-2 Hospitalization Variants of concern Delta Alpha |
| url | http://www.sciencedirect.com/science/article/pii/S1201971221012182 |
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