S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma
Highlights • Obesity negatively impacted progression-free survival and overall survival in lymphoma patients while an aggressive tumor growth pattern was found in obesity-lymphoma mice. • S1P-S1PR1/S1PR3-YAP signaling mediated lymphomagenesis contributing to tumor aggressive growth in obesity-lympho...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-022-02589-7 |
| _version_ | 1797958433944633344 |
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| author | Xingtong Wang Wei Guo Xiaoju Shi Yujia Chen Youxi Yu Beibei Du Min Tan Li Tong Anna Wang Xianying Yin Jing Guo Robert C. Martin Ou Bai Yan Li |
| author_facet | Xingtong Wang Wei Guo Xiaoju Shi Yujia Chen Youxi Yu Beibei Du Min Tan Li Tong Anna Wang Xianying Yin Jing Guo Robert C. Martin Ou Bai Yan Li |
| author_sort | Xingtong Wang |
| collection | DOAJ |
| description | Highlights • Obesity negatively impacted progression-free survival and overall survival in lymphoma patients while an aggressive tumor growth pattern was found in obesity-lymphoma mice. • S1P-S1PR1/S1PR3-YAP signaling mediated lymphomagenesis contributing to tumor aggressive growth in obesity-lymphoma. • S1P-ALOX15 signaling mediated TAMs contributing to immunosuppressive microenvironment in obesity-lymphoma. • S1P-targeted therapy could be potentially effective and immune-enhancive against obesity-lymphomagenesis. |
| first_indexed | 2024-04-11T00:20:04Z |
| format | Article |
| id | doaj.art-bdb3aeff498240b0b2b4c8f510739b12 |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-04-11T00:20:04Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-bdb3aeff498240b0b2b4c8f510739b122023-01-08T12:23:38ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662023-01-0142111710.1186/s13046-022-02589-7S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphomaXingtong Wang0Wei Guo1Xiaoju Shi2Yujia Chen3Youxi Yu4Beibei Du5Min Tan6Li Tong7Anna Wang8Xianying Yin9Jing Guo10Robert C. Martin11Ou Bai12Yan Li13Department of Surgery, School of Medicine, University of LouisvilleDepartment of Surgery, School of Medicine, University of LouisvilleDepartment of Surgery, School of Medicine, University of LouisvilleDepartment of Surgery, School of Medicine, University of LouisvilleDepartment of Surgery, School of Medicine, University of LouisvilleDepartment of Cardiology, China-Japan Union hospital of Jilin UniversityDepartment of Surgery, School of Medicine, University of LouisvilleDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin UniversityDepartment of Hematology, Cancer Center, The First Hospital of Jilin UniversityDepartment of Hematology, Cancer Center, The First Hospital of Jilin UniversityDepartment of Hematology, Cancer Center, The First Hospital of Jilin UniversityDepartment of Surgery, School of Medicine, University of LouisvilleDepartment of Hematology, Cancer Center, The First Hospital of Jilin UniversityDepartment of Surgery, School of Medicine, University of LouisvilleHighlights • Obesity negatively impacted progression-free survival and overall survival in lymphoma patients while an aggressive tumor growth pattern was found in obesity-lymphoma mice. • S1P-S1PR1/S1PR3-YAP signaling mediated lymphomagenesis contributing to tumor aggressive growth in obesity-lymphoma. • S1P-ALOX15 signaling mediated TAMs contributing to immunosuppressive microenvironment in obesity-lymphoma. • S1P-targeted therapy could be potentially effective and immune-enhancive against obesity-lymphomagenesis.https://doi.org/10.1186/s13046-022-02589-7LymphomaFree fatty acidS1P/SPHK signalingTumor microenvironmentObesity |
| spellingShingle | Xingtong Wang Wei Guo Xiaoju Shi Yujia Chen Youxi Yu Beibei Du Min Tan Li Tong Anna Wang Xianying Yin Jing Guo Robert C. Martin Ou Bai Yan Li S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma Journal of Experimental & Clinical Cancer Research Lymphoma Free fatty acid S1P/SPHK signaling Tumor microenvironment Obesity |
| title | S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma |
| title_full | S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma |
| title_fullStr | S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma |
| title_full_unstemmed | S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma |
| title_short | S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma |
| title_sort | s1pr1 s1pr3 yap signaling and s1p alox15 signaling contribute to an aggressive behavior in obesity lymphoma |
| topic | Lymphoma Free fatty acid S1P/SPHK signaling Tumor microenvironment Obesity |
| url | https://doi.org/10.1186/s13046-022-02589-7 |
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