S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma

S1PR1/S1PR3-YAP signaling and S1P-ALOX15 signaling contribute to an aggressive behavior in obesity-lymphoma

Highlights • Obesity negatively impacted progression-free survival and overall survival in lymphoma patients while an aggressive tumor growth pattern was found in obesity-lymphoma mice. • S1P-S1PR1/S1PR3-YAP signaling mediated lymphomagenesis contributing to tumor aggressive growth in obesity-lympho...

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Bibliographic Details
Main Authors: Xingtong Wang, Wei Guo, Xiaoju Shi, Yujia Chen, Youxi Yu, Beibei Du, Min Tan, Li Tong, Anna Wang, Xianying Yin, Jing Guo, Robert C. Martin, Ou Bai, Yan Li
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Lymphoma
Free fatty acid
S1P/SPHK signaling
Tumor microenvironment
Obesity
Online Access:https://doi.org/10.1186/s13046-022-02589-7

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