Loss of glucocorticoid receptor phosphorylation contributes to cognitive and neurocentric damages of the amyloid-β pathway

Loss of glucocorticoid receptor phosphorylation contributes to cognitive and neurocentric damages of the amyloid-β pathway

Abstract Aberrant cortisol and activation of the glucocorticoid receptor (GR) play an essential role in age-related progression of Alzheimer's disease (AD). However, the GR pathways required for influencing the pathobiology of AD dementia remain unknown. To address this, we studied an early pha...

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Bibliographic Details
Main Authors: Yann Dromard, Margarita Arango-Lievano, Amelie Borie, Maheva Dedin, Pierre Fontanaud, Joan Torrent, Michael J. Garabedian, Stephen D. Ginsberg, Freddy Jeanneteau
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Acta Neuropathologica Communications
Subjects:
Glucocorticoid receptor
BDNF
Memory
Neuroimaging
Spine dynamics
Online Access:https://doi.org/10.1186/s40478-022-01396-7

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