Biochemical Evaluation of the Therapeutic Effectiveness of Honey in Oral Mucosal Ulcers
The aim of this study was to describe and quantify the therapeutic value of honey in oral mucosal ulcers healing in comparison with Glyceroloxytriester (TGO). We also aimed to biochemically evaluate the healing effects of honey which had been collected from the Blacksea region flora on mucosal ulcer...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2009-11-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/2781 |
| _version_ | 1797260844233392128 |
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| author | Nergiz Yılmaz Özlem Nisbet Cevat Nisbet Gözlem Ceylan Fatih Hoşgör Ö.Doğu Dede |
| author_facet | Nergiz Yılmaz Özlem Nisbet Cevat Nisbet Gözlem Ceylan Fatih Hoşgör Ö.Doğu Dede |
| author_sort | Nergiz Yılmaz |
| collection | DOAJ |
| description | The aim of this study was to describe and quantify the therapeutic value of honey in oral mucosal ulcers healing in comparison with Glyceroloxytriester (TGO). We also aimed to biochemically evaluate the healing effects of honey which had been collected from the Blacksea region flora on mucosal ulcers resulting in material loss.
Thirty wistar rats (240±30 g) were enrolled in this study. Excisional wounds were performed in all rats for animal oral mucosal ulcer model. They were randomly allocated to three groups: group 1 was treated with Apitherapeutic agent or honey (0,1 ml, 2x1), group 2 was treated with TGO (0,1ml, 2x1) locally, Group 3 served as the control group.
Following the surgical procedure on day 7, biopsy specimens were taken from right buccal mucosa and on day 14 biopsy specimens were taken from left bucal mucosa in all rats. Afterwards, hydroxy pyroline levels were measured. Data were analyzed statistically
There was no statistically significant difference between Group 1 and 2, and also between Group 2 and 3, but there was statistically significant difference between Group 1 and 3 on day 7. There was no statistically significant difference between Group 1, 2 and 3 on day 14.
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| first_indexed | 2024-04-24T23:31:47Z |
| format | Article |
| id | doaj.art-bdb6b489dc6940c3be6f7ecac5cbc24a |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:31:47Z |
| publishDate | 2009-11-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-bdb6b489dc6940c3be6f7ecac5cbc24a2024-03-15T14:37:09ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2009-11-019410.17305/bjbms.2009.2781475Biochemical Evaluation of the Therapeutic Effectiveness of Honey in Oral Mucosal UlcersNergiz Yılmaz0Özlem Nisbet1Cevat Nisbet2Gözlem Ceylan3Fatih Hoşgör4Ö.Doğu Dede5Department of Oral and Maxillofacial Surgery, Dental Faculty, Ondokuz Mayis UniversityDepartment of Surgery, Veterinerian Faculty, Ondokuz Mayis UniversityDepartment of Biochemistry, Veterinerian Faculty, Ondokuz Mayis UniversityDepartment of Prosthodontics, Dental Faculty, Ondokuz Mayis UniversityDepartment of Oral and Maxillofacial Surgery, Dental Faculty, Ondokuz Mayis UniversityDepartment of Prosthodontics, Dental Faculty, Ondokuz Mayis UniversityThe aim of this study was to describe and quantify the therapeutic value of honey in oral mucosal ulcers healing in comparison with Glyceroloxytriester (TGO). We also aimed to biochemically evaluate the healing effects of honey which had been collected from the Blacksea region flora on mucosal ulcers resulting in material loss. Thirty wistar rats (240±30 g) were enrolled in this study. Excisional wounds were performed in all rats for animal oral mucosal ulcer model. They were randomly allocated to three groups: group 1 was treated with Apitherapeutic agent or honey (0,1 ml, 2x1), group 2 was treated with TGO (0,1ml, 2x1) locally, Group 3 served as the control group. Following the surgical procedure on day 7, biopsy specimens were taken from right buccal mucosa and on day 14 biopsy specimens were taken from left bucal mucosa in all rats. Afterwards, hydroxy pyroline levels were measured. Data were analyzed statistically There was no statistically significant difference between Group 1 and 2, and also between Group 2 and 3, but there was statistically significant difference between Group 1 and 3 on day 7. There was no statistically significant difference between Group 1, 2 and 3 on day 14. https://www.bjbms.org/ojs/index.php/bjbms/article/view/2781honeyoral ulcershydroxy pyroline |
| spellingShingle | Nergiz Yılmaz Özlem Nisbet Cevat Nisbet Gözlem Ceylan Fatih Hoşgör Ö.Doğu Dede Biochemical Evaluation of the Therapeutic Effectiveness of Honey in Oral Mucosal Ulcers Biomolecules & Biomedicine honey oral ulcers hydroxy pyroline |
| title | Biochemical Evaluation of the Therapeutic Effectiveness of Honey in Oral Mucosal Ulcers |
| title_full | Biochemical Evaluation of the Therapeutic Effectiveness of Honey in Oral Mucosal Ulcers |
| title_fullStr | Biochemical Evaluation of the Therapeutic Effectiveness of Honey in Oral Mucosal Ulcers |
| title_full_unstemmed | Biochemical Evaluation of the Therapeutic Effectiveness of Honey in Oral Mucosal Ulcers |
| title_short | Biochemical Evaluation of the Therapeutic Effectiveness of Honey in Oral Mucosal Ulcers |
| title_sort | biochemical evaluation of the therapeutic effectiveness of honey in oral mucosal ulcers |
| topic | honey oral ulcers hydroxy pyroline |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/2781 |
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