Prevalence and genotype distribution of HPV6/11/16/18 infections among 180,276 outpatient females from a Women’s and Children’s Central Hospital, 2015–2021, Chengdu, China
Abstract The aims of this study on human papilloma virus (HPV) 6/11/16/18 infection among females in Chengdu were to provide more targeted strategies for the prevention and treatment of cervical cancer and genital warts. In this study, the infection status of 20 genotypes was analysed by gene chip t...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-48222-1 |
| _version_ | 1797388365273759744 |
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| author | Xiaoqing Wei Junying Zhang Youwen Mei Qianling Dai Xiaoli Yang Xuemei Wang |
| author_facet | Xiaoqing Wei Junying Zhang Youwen Mei Qianling Dai Xiaoli Yang Xuemei Wang |
| author_sort | Xiaoqing Wei |
| collection | DOAJ |
| description | Abstract The aims of this study on human papilloma virus (HPV) 6/11/16/18 infection among females in Chengdu were to provide more targeted strategies for the prevention and treatment of cervical cancer and genital warts. In this study, the infection status of 20 genotypes was analysed by gene chip technology. The prevalence rates of HPV-6, -11, -16, and -18 infection among 180,276 cases were 0.94%, 0.57%, 3.22%, and 1.28%, respectively. The prevalence of HPV 6/11/16/18 showed a bimodal U-shaped curve with age; the first and second peak occurred among females < 20 and ≥ 60 years old, respectively. As the multiplicity of infections involving HPV6/11/16/18 increases, the infection rate decreases. The ratios of HPV16 single infection showed a yearly increase. The top five genotypes with HPV-16, -18, -6, and -11 in coinfection were HPV52/58/53/51/33, HPV 52/16/53/58/51, HPV52/16/58/51/53 and HPV16/52/58/59/18, respectively, HPV16/18/6/11 were mainly coinfected with HR-HPV. In sum, among the five vaccines available, nonavalent vaccine is more suitable for Chengdu females. For young females prioritizing vaccination is essential in the current context, while HPV screening remains an effective approach for older females. Additionally, in patients with genital warts, it is necessary to assess the presence of high-risk HPV infection and manage it appropriately in patients with genital warts. |
| first_indexed | 2024-03-08T22:38:43Z |
| format | Article |
| id | doaj.art-bdb75bcd39494b659f87fdf5c6d5a098 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T22:38:43Z |
| publishDate | 2023-12-01 |
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| series | Scientific Reports |
| spelling | doaj.art-bdb75bcd39494b659f87fdf5c6d5a0982023-12-17T12:17:52ZengNature PortfolioScientific Reports2045-23222023-12-0113111210.1038/s41598-023-48222-1Prevalence and genotype distribution of HPV6/11/16/18 infections among 180,276 outpatient females from a Women’s and Children’s Central Hospital, 2015–2021, Chengdu, ChinaXiaoqing Wei0Junying Zhang1Youwen Mei2Qianling Dai3Xiaoli Yang4Xuemei Wang5Department of Cervical Disease and Cervical Cancer Prevention and Treatment, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaClinical Laboratory Department, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaDepartment of Assisted reproduction department, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaDepartment of Cervical Disease and Cervical Cancer Prevention and Treatment, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaDepartment of Cervical Disease and Cervical Cancer Prevention and Treatment, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaClinical Laboratory Department, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of ChinaAbstract The aims of this study on human papilloma virus (HPV) 6/11/16/18 infection among females in Chengdu were to provide more targeted strategies for the prevention and treatment of cervical cancer and genital warts. In this study, the infection status of 20 genotypes was analysed by gene chip technology. The prevalence rates of HPV-6, -11, -16, and -18 infection among 180,276 cases were 0.94%, 0.57%, 3.22%, and 1.28%, respectively. The prevalence of HPV 6/11/16/18 showed a bimodal U-shaped curve with age; the first and second peak occurred among females < 20 and ≥ 60 years old, respectively. As the multiplicity of infections involving HPV6/11/16/18 increases, the infection rate decreases. The ratios of HPV16 single infection showed a yearly increase. The top five genotypes with HPV-16, -18, -6, and -11 in coinfection were HPV52/58/53/51/33, HPV 52/16/53/58/51, HPV52/16/58/51/53 and HPV16/52/58/59/18, respectively, HPV16/18/6/11 were mainly coinfected with HR-HPV. In sum, among the five vaccines available, nonavalent vaccine is more suitable for Chengdu females. For young females prioritizing vaccination is essential in the current context, while HPV screening remains an effective approach for older females. Additionally, in patients with genital warts, it is necessary to assess the presence of high-risk HPV infection and manage it appropriately in patients with genital warts.https://doi.org/10.1038/s41598-023-48222-1 |
| spellingShingle | Xiaoqing Wei Junying Zhang Youwen Mei Qianling Dai Xiaoli Yang Xuemei Wang Prevalence and genotype distribution of HPV6/11/16/18 infections among 180,276 outpatient females from a Women’s and Children’s Central Hospital, 2015–2021, Chengdu, China Scientific Reports |
| title | Prevalence and genotype distribution of HPV6/11/16/18 infections among 180,276 outpatient females from a Women’s and Children’s Central Hospital, 2015–2021, Chengdu, China |
| title_full | Prevalence and genotype distribution of HPV6/11/16/18 infections among 180,276 outpatient females from a Women’s and Children’s Central Hospital, 2015–2021, Chengdu, China |
| title_fullStr | Prevalence and genotype distribution of HPV6/11/16/18 infections among 180,276 outpatient females from a Women’s and Children’s Central Hospital, 2015–2021, Chengdu, China |
| title_full_unstemmed | Prevalence and genotype distribution of HPV6/11/16/18 infections among 180,276 outpatient females from a Women’s and Children’s Central Hospital, 2015–2021, Chengdu, China |
| title_short | Prevalence and genotype distribution of HPV6/11/16/18 infections among 180,276 outpatient females from a Women’s and Children’s Central Hospital, 2015–2021, Chengdu, China |
| title_sort | prevalence and genotype distribution of hpv6 11 16 18 infections among 180 276 outpatient females from a women s and children s central hospital 2015 2021 chengdu china |
| url | https://doi.org/10.1038/s41598-023-48222-1 |
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