Vitamin D role in hepatitis B: focus on immune system and genetics mechanism
According to the World Health Organization (WHO) report, viral hepatitis has been a problem in human society. Vitamins play a significant role in preventing the hepatocarcinoma and liver cirrhosis. In this report, we will first focus on the vitamin D function in the immune system reactions, and then...
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| Language: | English |
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Elsevier
2022-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022028572 |
| _version_ | 1811320519825293312 |
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| author | Arghavan Asghari Fatemeh Jafari Maryam Jameshorani Hossein Chiti Mohsen Naseri Anahita Ghafourirankouhi Omid Kooshkaki Alireza Abdshah Negin Parsamanesh |
| author_facet | Arghavan Asghari Fatemeh Jafari Maryam Jameshorani Hossein Chiti Mohsen Naseri Anahita Ghafourirankouhi Omid Kooshkaki Alireza Abdshah Negin Parsamanesh |
| author_sort | Arghavan Asghari |
| collection | DOAJ |
| description | According to the World Health Organization (WHO) report, viral hepatitis has been a problem in human society. Vitamins play a significant role in preventing the hepatocarcinoma and liver cirrhosis. In this report, we will first focus on the vitamin D function in the immune system reactions, and then investigate its role in the viral infections and the signaling pathway of hepatitis B virus.The existence of the cytochrome P450 (CYP) 27B1 enzyme, which is involved in vitamin D synthesis in immune system cells, has drawn researchers ' attention to the field of immune system. Toll like receptor (TLR) play a significant role in the immune system, and are one of the primary receptors of the innate immune system. In addition, the synthesis of inflammatory cytokines, such as Interferon γ (IFNγ) and Interleukin-2 (IL-2) is one of the key roles of T helper type 1 (Th1) cells; these cells can suppress two cited cytokines via vitamin D. In the chronic phase of hepatitis B, Cytotoxic T lymphocytes (CTLs) cells have weaker performance than the acute phase of the disease. The association between vitamin D physiologies with viral infections is also confirmed by genetic studies, carried out on genetic variations of vitamin D receptor (VDR) R-encoding disease susceptibility gene. Vitamin D affects different phases of the disease. Therefore, further experiments in this area are proposed. |
| first_indexed | 2024-04-13T13:01:06Z |
| format | Article |
| id | doaj.art-bdb7654243ac4c34a5c95b1f679a9c75 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-13T13:01:06Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-bdb7654243ac4c34a5c95b1f679a9c752022-12-22T02:45:54ZengElsevierHeliyon2405-84402022-11-01811e11569Vitamin D role in hepatitis B: focus on immune system and genetics mechanismArghavan Asghari0Fatemeh Jafari1Maryam Jameshorani2Hossein Chiti3Mohsen Naseri4Anahita Ghafourirankouhi5Omid Kooshkaki6Alireza Abdshah7Negin Parsamanesh8Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran; Birjand University of Medical Sciences, Birjand, IranRadiation Oncology Research Center, Iran Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IranZanjan Metabolic Diseases Research Center, Zanjan University of Medical Science, Zanjan, Iran; Department of Internal Medicine, School of Medicine, Zanjan University of Medical Science, Zanjan, IranZanjan Metabolic Diseases Research Center, Zanjan University of Medical Science, Zanjan, IranDepartment of Immunology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran; Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, IranZanjan University of Medical Science, Zanjan, IranBirjand University of Medical Sciences, Birjand, IranSchool of Medicine, Tehran University of Medical Science, Tehran, IranZanjan Metabolic Diseases Research Center, Zanjan University of Medical Science, Zanjan, Iran; Corresponding author.According to the World Health Organization (WHO) report, viral hepatitis has been a problem in human society. Vitamins play a significant role in preventing the hepatocarcinoma and liver cirrhosis. In this report, we will first focus on the vitamin D function in the immune system reactions, and then investigate its role in the viral infections and the signaling pathway of hepatitis B virus.The existence of the cytochrome P450 (CYP) 27B1 enzyme, which is involved in vitamin D synthesis in immune system cells, has drawn researchers ' attention to the field of immune system. Toll like receptor (TLR) play a significant role in the immune system, and are one of the primary receptors of the innate immune system. In addition, the synthesis of inflammatory cytokines, such as Interferon γ (IFNγ) and Interleukin-2 (IL-2) is one of the key roles of T helper type 1 (Th1) cells; these cells can suppress two cited cytokines via vitamin D. In the chronic phase of hepatitis B, Cytotoxic T lymphocytes (CTLs) cells have weaker performance than the acute phase of the disease. The association between vitamin D physiologies with viral infections is also confirmed by genetic studies, carried out on genetic variations of vitamin D receptor (VDR) R-encoding disease susceptibility gene. Vitamin D affects different phases of the disease. Therefore, further experiments in this area are proposed.http://www.sciencedirect.com/science/article/pii/S2405844022028572Vitamin DHepatitis BImmune systemGenetics |
| spellingShingle | Arghavan Asghari Fatemeh Jafari Maryam Jameshorani Hossein Chiti Mohsen Naseri Anahita Ghafourirankouhi Omid Kooshkaki Alireza Abdshah Negin Parsamanesh Vitamin D role in hepatitis B: focus on immune system and genetics mechanism Heliyon Vitamin D Hepatitis B Immune system Genetics |
| title | Vitamin D role in hepatitis B: focus on immune system and genetics mechanism |
| title_full | Vitamin D role in hepatitis B: focus on immune system and genetics mechanism |
| title_fullStr | Vitamin D role in hepatitis B: focus on immune system and genetics mechanism |
| title_full_unstemmed | Vitamin D role in hepatitis B: focus on immune system and genetics mechanism |
| title_short | Vitamin D role in hepatitis B: focus on immune system and genetics mechanism |
| title_sort | vitamin d role in hepatitis b focus on immune system and genetics mechanism |
| topic | Vitamin D Hepatitis B Immune system Genetics |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022028572 |
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