NTRK fusions in osteosarcoma are rare and non‐functional events

NTRK fusions in osteosarcoma are rare and non‐functional events

Abstract Neurotrophic tyrosine receptor kinase (NTRK) fusions are promising molecular targets that have been described in a broad range of malignant tumours. Fusions commonly lead to the expression of chimeric proteins with constitutive tyrosine kinase activation that drives tumorigenesis. Despite a...

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Bibliographic Details
Main Authors: Baptiste Ameline, Karim H Saba, Michal Kovac, Linda Magnusson, Olaf Witt, Stefan Bielack, Michaela Nathrath, Karolin H Nord, Daniel Baumhoer
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:The Journal of Pathology: Clinical Research
Subjects:
NTRK
tyrosine kinase inhibitors
osteosarcoma
Online Access:https://doi.org/10.1002/cjp2.158

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