Promising Strategies for Transdermal Delivery of Arthritis Drugs: Microneedle Systems
Arthritis is a general term for various types of inflammatory joint diseases. The most common clinical conditions are mainly represented by rheumatoid arthritis and osteoarthritis, which affect more than 4% of people worldwide and seriously limit their mobility. Arthritis medication generally requir...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/8/1736 |
| _version_ | 1797442725733203968 |
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| author | Jitong Wang Jia Zeng Zhidan Liu Qin Zhou Xin Wang Fan Zhao Yu Zhang Jiamiao Wang Minchen Liu Ruofei Du |
| author_facet | Jitong Wang Jia Zeng Zhidan Liu Qin Zhou Xin Wang Fan Zhao Yu Zhang Jiamiao Wang Minchen Liu Ruofei Du |
| author_sort | Jitong Wang |
| collection | DOAJ |
| description | Arthritis is a general term for various types of inflammatory joint diseases. The most common clinical conditions are mainly represented by rheumatoid arthritis and osteoarthritis, which affect more than 4% of people worldwide and seriously limit their mobility. Arthritis medication generally requires long-term application, while conventional administrations by oral delivery or injections may cause gastrointestinal side effects and are inconvenient for patients during long-term application. Emerging microneedle (MN) technology in recent years has created new avenues of transdermal delivery for arthritis drugs due to its advantages of painless skin perforation and efficient local delivery. This review summarizes various types of arthritis and current therapeutic agents. The current development of MNs in the delivery of arthritis drugs is highlighted, demonstrating their capabilities in achieving different drug release profiles through different self-enhancement methods or the incorporation of nanocarriers. Furthermore, the challenges of translating MNs from laboratory studies to the clinical practice and the marketplace are discussed. This promising technology provides a new approach to the current drug delivery paradigm in treating arthritis in transdermal delivery. |
| first_indexed | 2024-03-09T12:46:09Z |
| format | Article |
| id | doaj.art-bdba7394a3b1418fa7541f3388a98dac |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T12:46:09Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-bdba7394a3b1418fa7541f3388a98dac2023-11-30T22:12:16ZengMDPI AGPharmaceutics1999-49232022-08-01148173610.3390/pharmaceutics14081736Promising Strategies for Transdermal Delivery of Arthritis Drugs: Microneedle SystemsJitong Wang0Jia Zeng1Zhidan Liu2Qin Zhou3Xin Wang4Fan Zhao5Yu Zhang6Jiamiao Wang7Minchen Liu8Ruofei Du9Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaNHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai 200032, ChinaDepartment of Rehabilitation, Baoshan Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai 201999, ChinaEngineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaEngineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaEngineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaEngineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaEngineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaEngineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaArthritis is a general term for various types of inflammatory joint diseases. The most common clinical conditions are mainly represented by rheumatoid arthritis and osteoarthritis, which affect more than 4% of people worldwide and seriously limit their mobility. Arthritis medication generally requires long-term application, while conventional administrations by oral delivery or injections may cause gastrointestinal side effects and are inconvenient for patients during long-term application. Emerging microneedle (MN) technology in recent years has created new avenues of transdermal delivery for arthritis drugs due to its advantages of painless skin perforation and efficient local delivery. This review summarizes various types of arthritis and current therapeutic agents. The current development of MNs in the delivery of arthritis drugs is highlighted, demonstrating their capabilities in achieving different drug release profiles through different self-enhancement methods or the incorporation of nanocarriers. Furthermore, the challenges of translating MNs from laboratory studies to the clinical practice and the marketplace are discussed. This promising technology provides a new approach to the current drug delivery paradigm in treating arthritis in transdermal delivery.https://www.mdpi.com/1999-4923/14/8/1736arthritismicroneedletransdermal routedrug delivery |
| spellingShingle | Jitong Wang Jia Zeng Zhidan Liu Qin Zhou Xin Wang Fan Zhao Yu Zhang Jiamiao Wang Minchen Liu Ruofei Du Promising Strategies for Transdermal Delivery of Arthritis Drugs: Microneedle Systems Pharmaceutics arthritis microneedle transdermal route drug delivery |
| title | Promising Strategies for Transdermal Delivery of Arthritis Drugs: Microneedle Systems |
| title_full | Promising Strategies for Transdermal Delivery of Arthritis Drugs: Microneedle Systems |
| title_fullStr | Promising Strategies for Transdermal Delivery of Arthritis Drugs: Microneedle Systems |
| title_full_unstemmed | Promising Strategies for Transdermal Delivery of Arthritis Drugs: Microneedle Systems |
| title_short | Promising Strategies for Transdermal Delivery of Arthritis Drugs: Microneedle Systems |
| title_sort | promising strategies for transdermal delivery of arthritis drugs microneedle systems |
| topic | arthritis microneedle transdermal route drug delivery |
| url | https://www.mdpi.com/1999-4923/14/8/1736 |
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