Clinico-epidemiological Profile and Outcome of Testicular Germ Cell Tumors: A Retrospective Study from a Tertiary Cancer Centre of North-East India
Introduction: Testicular Germ Cell Tumor (GCT) is a disease of young adults and is also highly curable. But in India, most of the patients present in an advanced stage and succumb to the disease as compared to the Western nations where patients present at an earlier stage and are mostly cured. Also,...
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| Format: | Article |
| Language: | English |
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West Asia Organization for Cancer Prevention
2023-12-01
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| Series: | Asian Pacific Journal of Cancer Care |
| Subjects: | |
| Online Access: | http://www.waocp.com/journal/index.php/apjcc/article/view/1212 |
| _version_ | 1797342057613754368 |
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| author | Amritjot Singh Randhawa Manas Dubey Partha Sarathi Roy Munlima Hazarika Duncan Khanikar |
| author_facet | Amritjot Singh Randhawa Manas Dubey Partha Sarathi Roy Munlima Hazarika Duncan Khanikar |
| author_sort | Amritjot Singh Randhawa |
| collection | DOAJ |
| description | Introduction: Testicular Germ Cell Tumor (GCT) is a disease of young adults and is also highly curable. But in India, most of the patients present in an advanced stage and succumb to the disease as compared to the Western nations where patients present at an earlier stage and are mostly cured. Also, there is a scarcity of literature on testicular GCT from the Indian subcontinent. We present our experience from the Tata Memorial Centre of North-east India.
Methods: This retrospective study was conducted at Tata Memorial Centre - BBCI, Guwahati for the period of 5 years from January 2018 to December 2022. The study focused on epidemiology, clinical presentation, and treatment outcomes.
Results: Seventy-two cases of testicular GCTs were studied (28 cases were seminoma, and 44 were non-seminoma). Most common presenting stage was stage I in seminoma (53.6%), and stage III (77.2%) in non-seminoma. As per the International Germ Cell Cancer Collaborative Group (IGCCCG) classification, 25%, 35%, and 40% of patients were good-risk, intermediate-risk, and poor-risk in non-seminoma. In patients with seminoma, 54% and 46% were in good and intermediate-risk, respectively. Seventy-two percent and 21% had achieved a radiologic complete response (CR) and partial response (PR) with conventional chemotherapy in patients with seminoma. Radiologic CR and PR rates were 20% and 61% among non-seminoma patients. The median recurrence-free survival (RFS) was 43 months. RFS was better in seminoma versus non-seminoma, stage I versus stage III, and good-risk versus high-risk group.
Conclusion: Most of our patients presented with an advanced stage of the disease and a high nodal burden. In patients with non-seminoma GCT, the best response to conventional chemotherapy was a partial response. The use of an alternative chemotherapy regimen to improve outcomes for such patients can be further explored. |
| first_indexed | 2024-03-08T10:27:54Z |
| format | Article |
| id | doaj.art-bdbe1f548676441c94b7064e5671dd10 |
| institution | Directory Open Access Journal |
| issn | 2588-3682 |
| language | English |
| last_indexed | 2024-03-08T10:27:54Z |
| publishDate | 2023-12-01 |
| publisher | West Asia Organization for Cancer Prevention |
| record_format | Article |
| series | Asian Pacific Journal of Cancer Care |
| spelling | doaj.art-bdbe1f548676441c94b7064e5671dd102024-01-27T07:07:39ZengWest Asia Organization for Cancer PreventionAsian Pacific Journal of Cancer Care2588-36822023-12-018472973410.31557/apjcc.2023.8.4.729-7341212Clinico-epidemiological Profile and Outcome of Testicular Germ Cell Tumors: A Retrospective Study from a Tertiary Cancer Centre of North-East IndiaAmritjot Singh Randhawa0Manas Dubey1Partha Sarathi Roy2Munlima Hazarika3Duncan Khanikar4Department of Medical Oncology, Tata Memorial Centre - BBCI (Dr. Bhubaneswar Borooah Cancer Institute), Guwahati, India.Department of Medical Oncology, Tata Memorial Centre - BBCI (Dr. Bhubaneswar Borooah Cancer Institute), Guwahati, India.Department of Medical Oncology, Tata Memorial Centre - BBCI (Dr. Bhubaneswar Borooah Cancer Institute), Guwahati, India.Department of Medical Oncology, Tata Memorial Centre - BBCI (Dr. Bhubaneswar Borooah Cancer Institute), Guwahati, India.Department of Medical Oncology, Tata Memorial Centre - BBCI (Dr. Bhubaneswar Borooah Cancer Institute), Guwahati, India.Introduction: Testicular Germ Cell Tumor (GCT) is a disease of young adults and is also highly curable. But in India, most of the patients present in an advanced stage and succumb to the disease as compared to the Western nations where patients present at an earlier stage and are mostly cured. Also, there is a scarcity of literature on testicular GCT from the Indian subcontinent. We present our experience from the Tata Memorial Centre of North-east India. Methods: This retrospective study was conducted at Tata Memorial Centre - BBCI, Guwahati for the period of 5 years from January 2018 to December 2022. The study focused on epidemiology, clinical presentation, and treatment outcomes. Results: Seventy-two cases of testicular GCTs were studied (28 cases were seminoma, and 44 were non-seminoma). Most common presenting stage was stage I in seminoma (53.6%), and stage III (77.2%) in non-seminoma. As per the International Germ Cell Cancer Collaborative Group (IGCCCG) classification, 25%, 35%, and 40% of patients were good-risk, intermediate-risk, and poor-risk in non-seminoma. In patients with seminoma, 54% and 46% were in good and intermediate-risk, respectively. Seventy-two percent and 21% had achieved a radiologic complete response (CR) and partial response (PR) with conventional chemotherapy in patients with seminoma. Radiologic CR and PR rates were 20% and 61% among non-seminoma patients. The median recurrence-free survival (RFS) was 43 months. RFS was better in seminoma versus non-seminoma, stage I versus stage III, and good-risk versus high-risk group. Conclusion: Most of our patients presented with an advanced stage of the disease and a high nodal burden. In patients with non-seminoma GCT, the best response to conventional chemotherapy was a partial response. The use of an alternative chemotherapy regimen to improve outcomes for such patients can be further explored.http://www.waocp.com/journal/index.php/apjcc/article/view/1212seminomanon-seminomametastasissurvivaltesticular germ cell tumourepidemiologyoutcomes |
| spellingShingle | Amritjot Singh Randhawa Manas Dubey Partha Sarathi Roy Munlima Hazarika Duncan Khanikar Clinico-epidemiological Profile and Outcome of Testicular Germ Cell Tumors: A Retrospective Study from a Tertiary Cancer Centre of North-East India Asian Pacific Journal of Cancer Care seminoma non-seminoma metastasis survival testicular germ cell tumour epidemiology outcomes |
| title | Clinico-epidemiological Profile and Outcome of Testicular Germ Cell Tumors: A Retrospective Study from a Tertiary Cancer Centre of North-East India |
| title_full | Clinico-epidemiological Profile and Outcome of Testicular Germ Cell Tumors: A Retrospective Study from a Tertiary Cancer Centre of North-East India |
| title_fullStr | Clinico-epidemiological Profile and Outcome of Testicular Germ Cell Tumors: A Retrospective Study from a Tertiary Cancer Centre of North-East India |
| title_full_unstemmed | Clinico-epidemiological Profile and Outcome of Testicular Germ Cell Tumors: A Retrospective Study from a Tertiary Cancer Centre of North-East India |
| title_short | Clinico-epidemiological Profile and Outcome of Testicular Germ Cell Tumors: A Retrospective Study from a Tertiary Cancer Centre of North-East India |
| title_sort | clinico epidemiological profile and outcome of testicular germ cell tumors a retrospective study from a tertiary cancer centre of north east india |
| topic | seminoma non-seminoma metastasis survival testicular germ cell tumour epidemiology outcomes |
| url | http://www.waocp.com/journal/index.php/apjcc/article/view/1212 |
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