The value of endoscopic resection for non-ampullary duodenal lesions: A single-center experience
Background: To observe and preliminarily evaluate the efficacy and safety of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) in the treatment of non-ampullary duodenal lesions (NADLs). Methods: This retrospective observational study included 84 patients who underwent en...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2021;volume=27;issue=5;spage=302;epage=308;aulast=Li |
| _version_ | 1819145343056478208 |
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| author | Zhengqi Li Lizhou Dou Yong Liu Yueming Zhang Shun He Jiqing Zhu Yan Ke Xudong Liu Yumeng Liu Hoiloi Ng Guiqi Wang |
| author_facet | Zhengqi Li Lizhou Dou Yong Liu Yueming Zhang Shun He Jiqing Zhu Yan Ke Xudong Liu Yumeng Liu Hoiloi Ng Guiqi Wang |
| author_sort | Zhengqi Li |
| collection | DOAJ |
| description | Background: To observe and preliminarily evaluate the efficacy and safety of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) in the treatment of non-ampullary duodenal lesions (NADLs).
Methods: This retrospective observational study included 84 patients who underwent endoscopic resection (ER) with non-ampullary duodenal lesions, between March 2010 and November 2020, at the Cancer Hospital of the Chinese Academy of Medical Sciences (Beijing, China). Data on patient demographics, therapeutic outcomes, and follow-up results were analyzed.
Results: There were 44 patients undergoing EMR, and 40 patients accepting ESD. The overall en bloc resection rate was 98.8% (83/84). For the neoplastic lesions, the overall en bloc resection rate and curative rate were 98.5% (67/68) and 89.7% (61/68), respectively. The procedure-related bleeding and perforation rates were 2.4% and 10.7%, respectively. Univariate analysis results indicated that the main correlation factor of non-curative pathologic resection was tumor size (p = 0.004) and resection size (P < 0.01). There showed a higher curative rate in patients with tumors less than 25 mm in diameter. Multivariate logistic regression analyses determined that the tumor size (OR 0.935; 95% CI 0.878-0.995; P = 0.035) was associated with non-curative resection. No recurrences were observed in patients who had undergone a complete ER during a follow-up period of 42.8 months (range, 3-127 months).
Conclusion: Endoscopic resection is an effective, safe, and feasible treatment for non-ampullary duodenal lesions. |
| first_indexed | 2024-12-22T12:56:31Z |
| format | Article |
| id | doaj.art-bdbe96941fdd402da6eb3684c96f86d5 |
| institution | Directory Open Access Journal |
| issn | 1319-3767 1998-4049 |
| language | English |
| last_indexed | 2024-12-22T12:56:31Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-bdbe96941fdd402da6eb3684c96f86d52022-12-21T18:25:06ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492021-01-0127530230810.4103/sjg.sjg_646_20The value of endoscopic resection for non-ampullary duodenal lesions: A single-center experienceZhengqi LiLizhou DouYong LiuYueming ZhangShun HeJiqing ZhuYan KeXudong LiuYumeng LiuHoiloi NgGuiqi WangBackground: To observe and preliminarily evaluate the efficacy and safety of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) in the treatment of non-ampullary duodenal lesions (NADLs). Methods: This retrospective observational study included 84 patients who underwent endoscopic resection (ER) with non-ampullary duodenal lesions, between March 2010 and November 2020, at the Cancer Hospital of the Chinese Academy of Medical Sciences (Beijing, China). Data on patient demographics, therapeutic outcomes, and follow-up results were analyzed. Results: There were 44 patients undergoing EMR, and 40 patients accepting ESD. The overall en bloc resection rate was 98.8% (83/84). For the neoplastic lesions, the overall en bloc resection rate and curative rate were 98.5% (67/68) and 89.7% (61/68), respectively. The procedure-related bleeding and perforation rates were 2.4% and 10.7%, respectively. Univariate analysis results indicated that the main correlation factor of non-curative pathologic resection was tumor size (p = 0.004) and resection size (P < 0.01). There showed a higher curative rate in patients with tumors less than 25 mm in diameter. Multivariate logistic regression analyses determined that the tumor size (OR 0.935; 95% CI 0.878-0.995; P = 0.035) was associated with non-curative resection. No recurrences were observed in patients who had undergone a complete ER during a follow-up period of 42.8 months (range, 3-127 months). Conclusion: Endoscopic resection is an effective, safe, and feasible treatment for non-ampullary duodenal lesions.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2021;volume=27;issue=5;spage=302;epage=308;aulast=Liendoscopic resectionnon-ampullary duodenal lesions |
| spellingShingle | Zhengqi Li Lizhou Dou Yong Liu Yueming Zhang Shun He Jiqing Zhu Yan Ke Xudong Liu Yumeng Liu Hoiloi Ng Guiqi Wang The value of endoscopic resection for non-ampullary duodenal lesions: A single-center experience The Saudi Journal of Gastroenterology endoscopic resection non-ampullary duodenal lesions |
| title | The value of endoscopic resection for non-ampullary duodenal lesions: A single-center experience |
| title_full | The value of endoscopic resection for non-ampullary duodenal lesions: A single-center experience |
| title_fullStr | The value of endoscopic resection for non-ampullary duodenal lesions: A single-center experience |
| title_full_unstemmed | The value of endoscopic resection for non-ampullary duodenal lesions: A single-center experience |
| title_short | The value of endoscopic resection for non-ampullary duodenal lesions: A single-center experience |
| title_sort | value of endoscopic resection for non ampullary duodenal lesions a single center experience |
| topic | endoscopic resection non-ampullary duodenal lesions |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2021;volume=27;issue=5;spage=302;epage=308;aulast=Li |
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