Adiponectin in Chronic Kidney Disease
Adiponectin is the adipokine associated with insulin sensitization, reducing liver gluconeogenesis, and increasing fatty acid oxidation and glucose uptake. Adiponectin is present in the kidneys, mainly in the arterial endothelium and smooth muscle cells, as well as in the capillary endothelium, and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/24/9375 |
| _version_ | 1797545263571664896 |
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| author | Jarosław Przybyciński Violetta Dziedziejko Kamila Puchałowicz Leszek Domański Andrzej Pawlik |
| author_facet | Jarosław Przybyciński Violetta Dziedziejko Kamila Puchałowicz Leszek Domański Andrzej Pawlik |
| author_sort | Jarosław Przybyciński |
| collection | DOAJ |
| description | Adiponectin is the adipokine associated with insulin sensitization, reducing liver gluconeogenesis, and increasing fatty acid oxidation and glucose uptake. Adiponectin is present in the kidneys, mainly in the arterial endothelium and smooth muscle cells, as well as in the capillary endothelium, and might be considered as a marker of many negative factors in chronic kidney disease. The last few years have brought a rising body of evidence that adiponectin is a multipotential protein with anti-inflammatory, metabolic, anti-atherogenic, and reactive oxygen species (ROS) protective actions. Similarly, adiponectin has shown many positive and direct actions in kidney diseases, and among many kidney cells. Data from large cross-sectional and cohort studies showed a positive correlation between serum adiponectin and mortality in chronic kidney disease. This suggests a complex interaction between local adiponectin action, comorbidities, and uremic milieu. In this review we discuss the role of adiponectin in chronic kidney disease. |
| first_indexed | 2024-03-10T14:13:01Z |
| format | Article |
| id | doaj.art-bdbf3ffbab7344c6a8c62718d4af106a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:13:01Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-bdbf3ffbab7344c6a8c62718d4af106a2023-11-21T00:01:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-012124937510.3390/ijms21249375Adiponectin in Chronic Kidney DiseaseJarosław Przybyciński0Violetta Dziedziejko1Kamila Puchałowicz2Leszek Domański3Andrzej Pawlik4Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72, 70-111 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72, 70-111 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72, 70-111 Szczecin, PolandDepartment of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University in Szczecin, Powstańców Wlkp. 72, 70-111 Szczecin, PolandAdiponectin is the adipokine associated with insulin sensitization, reducing liver gluconeogenesis, and increasing fatty acid oxidation and glucose uptake. Adiponectin is present in the kidneys, mainly in the arterial endothelium and smooth muscle cells, as well as in the capillary endothelium, and might be considered as a marker of many negative factors in chronic kidney disease. The last few years have brought a rising body of evidence that adiponectin is a multipotential protein with anti-inflammatory, metabolic, anti-atherogenic, and reactive oxygen species (ROS) protective actions. Similarly, adiponectin has shown many positive and direct actions in kidney diseases, and among many kidney cells. Data from large cross-sectional and cohort studies showed a positive correlation between serum adiponectin and mortality in chronic kidney disease. This suggests a complex interaction between local adiponectin action, comorbidities, and uremic milieu. In this review we discuss the role of adiponectin in chronic kidney disease.https://www.mdpi.com/1422-0067/21/24/9375adiponectin receptorsatherosclerosisbonediabetesdialysiskidney |
| spellingShingle | Jarosław Przybyciński Violetta Dziedziejko Kamila Puchałowicz Leszek Domański Andrzej Pawlik Adiponectin in Chronic Kidney Disease International Journal of Molecular Sciences adiponectin receptors atherosclerosis bone diabetes dialysis kidney |
| title | Adiponectin in Chronic Kidney Disease |
| title_full | Adiponectin in Chronic Kidney Disease |
| title_fullStr | Adiponectin in Chronic Kidney Disease |
| title_full_unstemmed | Adiponectin in Chronic Kidney Disease |
| title_short | Adiponectin in Chronic Kidney Disease |
| title_sort | adiponectin in chronic kidney disease |
| topic | adiponectin receptors atherosclerosis bone diabetes dialysis kidney |
| url | https://www.mdpi.com/1422-0067/21/24/9375 |
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