Metallopanstimulin as a marker for head and neck cancer
<p>Abstract</p> <p>Background</p> <p>Metallopanstimulin (MPS-1) is a ribosomal protein that is found in elevated amounts in the sera of patients with head and neck squamous cell carcinoma (HNSCC). We used a test, denoted MPS-H, which detects MPS-1 and MPS-1-like protein...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2004-12-01
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| Series: | World Journal of Surgical Oncology |
| Online Access: | http://www.wjso.com/content/2/1/45 |
| _version_ | 1818347835658076160 |
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| author | Dunphy Frank R Lee Christopher M Hollenbeak Christopher S Stack Brendan C Lowe Val J Hamilton Paul D |
| author_facet | Dunphy Frank R Lee Christopher M Hollenbeak Christopher S Stack Brendan C Lowe Val J Hamilton Paul D |
| author_sort | Dunphy Frank R |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Metallopanstimulin (MPS-1) is a ribosomal protein that is found in elevated amounts in the sera of patients with head and neck squamous cell carcinoma (HNSCC). We used a test, denoted MPS-H, which detects MPS-1 and MPS-1-like proteins, to determine the relationship between MPS-H serum levels and clinical status of patients with, or at risk for, HNSCC.</p> <p>Patients and methods</p> <p>A total of 125 patients were prospectively enrolled from a university head and neck oncology clinic. Participants included only newly diagnosed HNSCC patients. Two control groups, including 25 non-smokers and 64 smokers, were studied for comparison. A total of 821 serum samples collected over a twenty-four month period were analyzed by the MPS-H radioimmunoassay.</p> <p>Results</p> <p>HNSCC, non-smokers, and smokers had average MPS-H values of 41.5 ng/mL, 10.2 ng/mL, and 12.8 ng/mL, respectively (p = 0.0001).</p> <p>Conclusion</p> <p>We conclude that MPS-1 and MPS-1-like proteins are elevated in patients with HNSCC, and that MPS-H appears to be a promising marker of presence of disease and response to treatment in HNSCC patients.</p> |
| first_indexed | 2024-12-13T17:40:29Z |
| format | Article |
| id | doaj.art-bdbfb28abe51405cb73d9d2db47e5ee2 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-13T17:40:29Z |
| publishDate | 2004-12-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-bdbfb28abe51405cb73d9d2db47e5ee22022-12-21T23:36:47ZengBMCWorld Journal of Surgical Oncology1477-78192004-12-01214510.1186/1477-7819-2-45Metallopanstimulin as a marker for head and neck cancerDunphy Frank RLee Christopher MHollenbeak Christopher SStack Brendan CLowe Val JHamilton Paul D<p>Abstract</p> <p>Background</p> <p>Metallopanstimulin (MPS-1) is a ribosomal protein that is found in elevated amounts in the sera of patients with head and neck squamous cell carcinoma (HNSCC). We used a test, denoted MPS-H, which detects MPS-1 and MPS-1-like proteins, to determine the relationship between MPS-H serum levels and clinical status of patients with, or at risk for, HNSCC.</p> <p>Patients and methods</p> <p>A total of 125 patients were prospectively enrolled from a university head and neck oncology clinic. Participants included only newly diagnosed HNSCC patients. Two control groups, including 25 non-smokers and 64 smokers, were studied for comparison. A total of 821 serum samples collected over a twenty-four month period were analyzed by the MPS-H radioimmunoassay.</p> <p>Results</p> <p>HNSCC, non-smokers, and smokers had average MPS-H values of 41.5 ng/mL, 10.2 ng/mL, and 12.8 ng/mL, respectively (p = 0.0001).</p> <p>Conclusion</p> <p>We conclude that MPS-1 and MPS-1-like proteins are elevated in patients with HNSCC, and that MPS-H appears to be a promising marker of presence of disease and response to treatment in HNSCC patients.</p>http://www.wjso.com/content/2/1/45 |
| spellingShingle | Dunphy Frank R Lee Christopher M Hollenbeak Christopher S Stack Brendan C Lowe Val J Hamilton Paul D Metallopanstimulin as a marker for head and neck cancer World Journal of Surgical Oncology |
| title | Metallopanstimulin as a marker for head and neck cancer |
| title_full | Metallopanstimulin as a marker for head and neck cancer |
| title_fullStr | Metallopanstimulin as a marker for head and neck cancer |
| title_full_unstemmed | Metallopanstimulin as a marker for head and neck cancer |
| title_short | Metallopanstimulin as a marker for head and neck cancer |
| title_sort | metallopanstimulin as a marker for head and neck cancer |
| url | http://www.wjso.com/content/2/1/45 |
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