Ultra-High-Frequency Ultrasound as an Innovative Imaging Evaluation of Hyaluronic Acid Filler in Nasolabial Folds
Dermal hyaluronic acid (HA) fillers are used for nasolabial fold correction, but no study is still available on the use of ultra-high-frequency ultrasound (UHFUS) with 70 MHz probes for the evaluation of HA distribution and wrinkle amelioration. We selected 13 patients who received HA filler, evalua...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/17/2761 |
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| author | Giorgia Salvia Nicola Zerbinati Flavia Manzo Margiotta Alessandra Michelucci Giammarco Granieri Cristian Fidanzi Riccardo Morganti Marco Romanelli Valentina Dini |
| author_facet | Giorgia Salvia Nicola Zerbinati Flavia Manzo Margiotta Alessandra Michelucci Giammarco Granieri Cristian Fidanzi Riccardo Morganti Marco Romanelli Valentina Dini |
| author_sort | Giorgia Salvia |
| collection | DOAJ |
| description | Dermal hyaluronic acid (HA) fillers are used for nasolabial fold correction, but no study is still available on the use of ultra-high-frequency ultrasound (UHFUS) with 70 MHz probes for the evaluation of HA distribution and wrinkle amelioration. We selected 13 patients who received HA filler, evaluated before (Time (T) 0) and after injection (T1), and after 24 weeks (T2). The dermal thickness and distribution of HA were registered, as well as the Wrinkle Severity Rating Scale (WSRS), Global Aesthetic Improvement Scale (GAIS), and wrinkle 3D fullness. The UHFUS dermal thickness was increased by 11% for both sides at T1 and by 7.4% and 6.8% for the right and left side, respectively, at T2 (<i>p</i> < 0.01). The 3D wrinkle fullness showed a T1 increase (+0.59 cc and +0.79 cc for the right and left side, respectively) with a T2 maintenance of 45% of the T1 fullness (<i>p</i>-value < 0.001). The only clinical score significantly modified was WSRS, with a reduction of 56% at T1 and of 47.1% at T2 (<i>p</i>-value < 0.001). Our study then demonstrated the efficacy of UHFUS in the assessment of nasolabial fold correction, representing also the first multi-modal evaluation of HA persistence and its visual subsequent aesthetic results. |
| first_indexed | 2024-03-10T23:26:07Z |
| format | Article |
| id | doaj.art-bdc50c025eb84f89b39cf75bd2f47832 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T23:26:07Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-bdc50c025eb84f89b39cf75bd2f478322023-11-19T07:59:13ZengMDPI AGDiagnostics2075-44182023-08-011317276110.3390/diagnostics13172761Ultra-High-Frequency Ultrasound as an Innovative Imaging Evaluation of Hyaluronic Acid Filler in Nasolabial FoldsGiorgia Salvia0Nicola Zerbinati1Flavia Manzo Margiotta2Alessandra Michelucci3Giammarco Granieri4Cristian Fidanzi5Riccardo Morganti6Marco Romanelli7Valentina Dini8Department of Dermatology, University of Pisa, 56126 Pisa, ItalyDermatologic Unit, Department of Medicine and Surgery, University of Insubria, 21100 Varese, ItalyDepartment of Dermatology, University of Pisa, 56126 Pisa, ItalyDepartment of Dermatology, University of Pisa, 56126 Pisa, ItalyDepartment of Dermatology, University of Pisa, 56126 Pisa, ItalyDepartment of Dermatology, University of Pisa, 56126 Pisa, ItalySection of Statistics, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyDepartment of Dermatology, University of Pisa, 56126 Pisa, ItalyDepartment of Dermatology, University of Pisa, 56126 Pisa, ItalyDermal hyaluronic acid (HA) fillers are used for nasolabial fold correction, but no study is still available on the use of ultra-high-frequency ultrasound (UHFUS) with 70 MHz probes for the evaluation of HA distribution and wrinkle amelioration. We selected 13 patients who received HA filler, evaluated before (Time (T) 0) and after injection (T1), and after 24 weeks (T2). The dermal thickness and distribution of HA were registered, as well as the Wrinkle Severity Rating Scale (WSRS), Global Aesthetic Improvement Scale (GAIS), and wrinkle 3D fullness. The UHFUS dermal thickness was increased by 11% for both sides at T1 and by 7.4% and 6.8% for the right and left side, respectively, at T2 (<i>p</i> < 0.01). The 3D wrinkle fullness showed a T1 increase (+0.59 cc and +0.79 cc for the right and left side, respectively) with a T2 maintenance of 45% of the T1 fullness (<i>p</i>-value < 0.001). The only clinical score significantly modified was WSRS, with a reduction of 56% at T1 and of 47.1% at T2 (<i>p</i>-value < 0.001). Our study then demonstrated the efficacy of UHFUS in the assessment of nasolabial fold correction, representing also the first multi-modal evaluation of HA persistence and its visual subsequent aesthetic results.https://www.mdpi.com/2075-4418/13/17/2761fillerultra-high-frequency ultrasoundhyaluronic acidaesthetic medicine |
| spellingShingle | Giorgia Salvia Nicola Zerbinati Flavia Manzo Margiotta Alessandra Michelucci Giammarco Granieri Cristian Fidanzi Riccardo Morganti Marco Romanelli Valentina Dini Ultra-High-Frequency Ultrasound as an Innovative Imaging Evaluation of Hyaluronic Acid Filler in Nasolabial Folds Diagnostics filler ultra-high-frequency ultrasound hyaluronic acid aesthetic medicine |
| title | Ultra-High-Frequency Ultrasound as an Innovative Imaging Evaluation of Hyaluronic Acid Filler in Nasolabial Folds |
| title_full | Ultra-High-Frequency Ultrasound as an Innovative Imaging Evaluation of Hyaluronic Acid Filler in Nasolabial Folds |
| title_fullStr | Ultra-High-Frequency Ultrasound as an Innovative Imaging Evaluation of Hyaluronic Acid Filler in Nasolabial Folds |
| title_full_unstemmed | Ultra-High-Frequency Ultrasound as an Innovative Imaging Evaluation of Hyaluronic Acid Filler in Nasolabial Folds |
| title_short | Ultra-High-Frequency Ultrasound as an Innovative Imaging Evaluation of Hyaluronic Acid Filler in Nasolabial Folds |
| title_sort | ultra high frequency ultrasound as an innovative imaging evaluation of hyaluronic acid filler in nasolabial folds |
| topic | filler ultra-high-frequency ultrasound hyaluronic acid aesthetic medicine |
| url | https://www.mdpi.com/2075-4418/13/17/2761 |
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