Usefulness of the APTT waveform for the diagnosis of DIC and prediction of the outcome or bleeding risk
Abstract Background The usefulness of the activated partial thromboplastin time (APTT) waveform has been reported in hemophilia, acquired hemophilia and monitoring for anticoagulants. Material and methods The APTT waveform was examined in patients suspected of having disseminated intravascular coagu...
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| Format: | Article |
| Language: | English |
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BMC
2019-06-01
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| Series: | Thrombosis Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12959-019-0201-0 |
| _version_ | 1818383352659443712 |
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| author | Kei Suzuki Hideo Wada Takeshi Matsumoto Makoto Ikejiri Kohshi Ohishi Yoshiki Yamashita Hiroshi Imai Toshiaki Iba Naoyuki Katayama |
| author_facet | Kei Suzuki Hideo Wada Takeshi Matsumoto Makoto Ikejiri Kohshi Ohishi Yoshiki Yamashita Hiroshi Imai Toshiaki Iba Naoyuki Katayama |
| author_sort | Kei Suzuki |
| collection | DOAJ |
| description | Abstract Background The usefulness of the activated partial thromboplastin time (APTT) waveform has been reported in hemophilia, acquired hemophilia and monitoring for anticoagulants. Material and methods The APTT waveform was examined in patients suspected of having disseminated intravascular coagulation (DIC) to analyze its usefulness for the diagnosis of DIC or the prediction of the outcome or bleeding risk. Results DIC with fibrinogen < 2 g/L was frequently associated with infectious diseases (43.3%). The heights of the first derivative peak (1stDP) and second DP (2ndDP) were extremely low in DIC, especially DIC with hypofibrinogenemia, but high in infectious patients without DIC. The peak time and width of the 1stDP and 2ndDP were prolonged in patients with DIC. The heights of the 1stDP and 2ndDP were markedly low in patients with a poor outcome or those with hemoglobin < 8.0 g/dl. Discussion and conclusion As bleeding type DIC was observed in infectious DIC, DIC without hypofibrinogenemia might switch to DIC with hypofibrinogenemia by the progression of DIC. The height of the 1stDP and 2ndDP is useful for the diagnosis of DIC and prediction of the bleeding risk or outcome. |
| first_indexed | 2024-12-14T03:05:00Z |
| format | Article |
| id | doaj.art-bdc55231676143878f5a64e96962c586 |
| institution | Directory Open Access Journal |
| issn | 1477-9560 |
| language | English |
| last_indexed | 2024-12-14T03:05:00Z |
| publishDate | 2019-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj.art-bdc55231676143878f5a64e96962c5862022-12-21T23:19:25ZengBMCThrombosis Journal1477-95602019-06-011711810.1186/s12959-019-0201-0Usefulness of the APTT waveform for the diagnosis of DIC and prediction of the outcome or bleeding riskKei Suzuki0Hideo Wada1Takeshi Matsumoto2Makoto Ikejiri3Kohshi Ohishi4Yoshiki Yamashita5Hiroshi Imai6Toshiaki Iba7Naoyuki Katayama8Emergency Critical Care Center, Mie University Graduate School of MedicineDepartments of Molecular and Laboratory Medicine, Mie University Graduate School of MedicineDivision of Blood Transfusion Medicine and Cell Therapy, Mie University Graduate School of MedicineCentral laboratory, Mie University Graduate School of MedicineDivision of Blood Transfusion Medicine and Cell Therapy, Mie University Graduate School of MedicineDepartment of Hematology and Oncology, Mie University Graduate School of MedicineEmergency Critical Care Center, Mie University Graduate School of MedicineDepartment of Emergency and Disaster Medicine, Juntendo University Graduate School of MedicineDepartment of Hematology and Oncology, Mie University Graduate School of MedicineAbstract Background The usefulness of the activated partial thromboplastin time (APTT) waveform has been reported in hemophilia, acquired hemophilia and monitoring for anticoagulants. Material and methods The APTT waveform was examined in patients suspected of having disseminated intravascular coagulation (DIC) to analyze its usefulness for the diagnosis of DIC or the prediction of the outcome or bleeding risk. Results DIC with fibrinogen < 2 g/L was frequently associated with infectious diseases (43.3%). The heights of the first derivative peak (1stDP) and second DP (2ndDP) were extremely low in DIC, especially DIC with hypofibrinogenemia, but high in infectious patients without DIC. The peak time and width of the 1stDP and 2ndDP were prolonged in patients with DIC. The heights of the 1stDP and 2ndDP were markedly low in patients with a poor outcome or those with hemoglobin < 8.0 g/dl. Discussion and conclusion As bleeding type DIC was observed in infectious DIC, DIC without hypofibrinogenemia might switch to DIC with hypofibrinogenemia by the progression of DIC. The height of the 1stDP and 2ndDP is useful for the diagnosis of DIC and prediction of the bleeding risk or outcome.http://link.springer.com/article/10.1186/s12959-019-0201-0APTT waveformHypofibrinogenemiaBleedingOutcome |
| spellingShingle | Kei Suzuki Hideo Wada Takeshi Matsumoto Makoto Ikejiri Kohshi Ohishi Yoshiki Yamashita Hiroshi Imai Toshiaki Iba Naoyuki Katayama Usefulness of the APTT waveform for the diagnosis of DIC and prediction of the outcome or bleeding risk Thrombosis Journal APTT waveform Hypofibrinogenemia Bleeding Outcome |
| title | Usefulness of the APTT waveform for the diagnosis of DIC and prediction of the outcome or bleeding risk |
| title_full | Usefulness of the APTT waveform for the diagnosis of DIC and prediction of the outcome or bleeding risk |
| title_fullStr | Usefulness of the APTT waveform for the diagnosis of DIC and prediction of the outcome or bleeding risk |
| title_full_unstemmed | Usefulness of the APTT waveform for the diagnosis of DIC and prediction of the outcome or bleeding risk |
| title_short | Usefulness of the APTT waveform for the diagnosis of DIC and prediction of the outcome or bleeding risk |
| title_sort | usefulness of the aptt waveform for the diagnosis of dic and prediction of the outcome or bleeding risk |
| topic | APTT waveform Hypofibrinogenemia Bleeding Outcome |
| url | http://link.springer.com/article/10.1186/s12959-019-0201-0 |
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