Non-alcoholic fatty liver disease and diabetes mellitus as growing aetiologies of hepatocellular carcinomaKey points
Summary: Obesity-related complications such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) are well-established risk factors for the development of hepatocellular carcinoma (HCC). This review provides insights into the molecular mechanisms that underlie the role of steatosis,...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | JHEP Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589555923001428 |
| _version_ | 1797732884266614784 |
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| author | Stephanie Talamantes Michela Lisjak Eduardo H. Gilglioni Camilo J. Llamoza-Torres Bruno Ramos-Molina Esteban N. Gurzov |
| author_facet | Stephanie Talamantes Michela Lisjak Eduardo H. Gilglioni Camilo J. Llamoza-Torres Bruno Ramos-Molina Esteban N. Gurzov |
| author_sort | Stephanie Talamantes |
| collection | DOAJ |
| description | Summary: Obesity-related complications such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) are well-established risk factors for the development of hepatocellular carcinoma (HCC). This review provides insights into the molecular mechanisms that underlie the role of steatosis, hyperinsulinemia and hepatic inflammation in HCC development and progression. We focus on recent findings linking intracellular pathways and transcription factors that can trigger the reprogramming of hepatic cells. In addition, we highlight the role of enzymes in dysregulated metabolic activity and consequent dysfunctional signalling. Finally, we discuss the potential uses and challenges of novel therapeutic strategies to prevent and treat NAFLD/T2D-associated HCC. |
| first_indexed | 2024-03-12T12:19:59Z |
| format | Article |
| id | doaj.art-bdc6868083954ef9bc3215c297727189 |
| institution | Directory Open Access Journal |
| issn | 2589-5559 |
| language | English |
| last_indexed | 2024-03-12T12:19:59Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JHEP Reports |
| spelling | doaj.art-bdc6868083954ef9bc3215c2977271892023-08-30T05:54:40ZengElsevierJHEP Reports2589-55592023-09-0159100811Non-alcoholic fatty liver disease and diabetes mellitus as growing aetiologies of hepatocellular carcinomaKey pointsStephanie Talamantes0Michela Lisjak1Eduardo H. Gilglioni2Camilo J. Llamoza-Torres3Bruno Ramos-Molina4Esteban N. Gurzov5Signal Transduction and Metabolism Laboratory, Laboratoire de Gastroentérologie Expérimental et Endotools, Université Libre de Bruxelles, Route de Lennik 808, Brussels, 1070, BelgiumSignal Transduction and Metabolism Laboratory, Laboratoire de Gastroentérologie Expérimental et Endotools, Université Libre de Bruxelles, Route de Lennik 808, Brussels, 1070, BelgiumSignal Transduction and Metabolism Laboratory, Laboratoire de Gastroentérologie Expérimental et Endotools, Université Libre de Bruxelles, Route de Lennik 808, Brussels, 1070, BelgiumDepartment of Hepatology, Virgen de la Arrixaca University Hospital, Murcia, 30120, Spain; Obesity and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), Murcia, 30120, SpainObesity and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), Murcia, 30120, SpainSignal Transduction and Metabolism Laboratory, Laboratoire de Gastroentérologie Expérimental et Endotools, Université Libre de Bruxelles, Route de Lennik 808, Brussels, 1070, Belgium; Obesity and Metabolism Laboratory, Biomedical Research Institute of Murcia (IMIB), Murcia, 30120, Spain; WELBIO Department, WEL Research Institute, Avenue Pasteur 6, Wavre, 1300, Belgium; Corresponding author. Address: Signal Transduction and Metabolism Laboratory, Route de Lennik 808, Brussels, B1070, Belgium; Tel.: +32 2 555 8908.Summary: Obesity-related complications such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) are well-established risk factors for the development of hepatocellular carcinoma (HCC). This review provides insights into the molecular mechanisms that underlie the role of steatosis, hyperinsulinemia and hepatic inflammation in HCC development and progression. We focus on recent findings linking intracellular pathways and transcription factors that can trigger the reprogramming of hepatic cells. In addition, we highlight the role of enzymes in dysregulated metabolic activity and consequent dysfunctional signalling. Finally, we discuss the potential uses and challenges of novel therapeutic strategies to prevent and treat NAFLD/T2D-associated HCC.http://www.sciencedirect.com/science/article/pii/S2589555923001428Hepatocellular carcinomaobesitynon-alcoholic fatty liver diseasetype 2 diabeteshepatocyte transformation |
| spellingShingle | Stephanie Talamantes Michela Lisjak Eduardo H. Gilglioni Camilo J. Llamoza-Torres Bruno Ramos-Molina Esteban N. Gurzov Non-alcoholic fatty liver disease and diabetes mellitus as growing aetiologies of hepatocellular carcinomaKey points JHEP Reports Hepatocellular carcinoma obesity non-alcoholic fatty liver disease type 2 diabetes hepatocyte transformation |
| title | Non-alcoholic fatty liver disease and diabetes mellitus as growing aetiologies of hepatocellular carcinomaKey points |
| title_full | Non-alcoholic fatty liver disease and diabetes mellitus as growing aetiologies of hepatocellular carcinomaKey points |
| title_fullStr | Non-alcoholic fatty liver disease and diabetes mellitus as growing aetiologies of hepatocellular carcinomaKey points |
| title_full_unstemmed | Non-alcoholic fatty liver disease and diabetes mellitus as growing aetiologies of hepatocellular carcinomaKey points |
| title_short | Non-alcoholic fatty liver disease and diabetes mellitus as growing aetiologies of hepatocellular carcinomaKey points |
| title_sort | non alcoholic fatty liver disease and diabetes mellitus as growing aetiologies of hepatocellular carcinomakey points |
| topic | Hepatocellular carcinoma obesity non-alcoholic fatty liver disease type 2 diabetes hepatocyte transformation |
| url | http://www.sciencedirect.com/science/article/pii/S2589555923001428 |
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