Histological Disorganization of Spleen Compartments and Severe Visceral Leishmaniasis
The spleen is a secondary lymphoid organ responsible for immune surveillance against blood-circulating pathogens. Absence of the spleen is associated with increased susceptibility to systemic spread and fatal infection by different pathogens. Severe forms of visceral leishmaniasis are associated wit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2018.00394/full |
| _version_ | 1818501447152566272 |
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| author | Micely d'El-Rei Hermida Caroline Vilas Boas de Melo Isadora dos Santos Lima Geraldo Gileno de Sá Oliveira Washington L. C. dos-Santos |
| author_facet | Micely d'El-Rei Hermida Caroline Vilas Boas de Melo Isadora dos Santos Lima Geraldo Gileno de Sá Oliveira Washington L. C. dos-Santos |
| author_sort | Micely d'El-Rei Hermida |
| collection | DOAJ |
| description | The spleen is a secondary lymphoid organ responsible for immune surveillance against blood-circulating pathogens. Absence of the spleen is associated with increased susceptibility to systemic spread and fatal infection by different pathogens. Severe forms of visceral leishmaniasis are associated with disorganization of spleen compartments where cell interactions essential for splenic immunological function take place. White pulp atrophies, secondary lymphoid follicles and marginal zones vanish, and the boundaries separating white and red pulp blur. Leukocyte populations are reduced or disappear or are replaced by plasma cells. In this paper, we review the published data on spleen disorganization in severe forms of visceral leishmaniasis and propose a histological classification to help the exchange of information among research groups. |
| first_indexed | 2024-12-10T20:56:18Z |
| format | Article |
| id | doaj.art-bdc8226277c349dab10faf2c2a0b5385 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-10T20:56:18Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-bdc8226277c349dab10faf2c2a0b53852022-12-22T01:33:57ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882018-11-01810.3389/fcimb.2018.00394408184Histological Disorganization of Spleen Compartments and Severe Visceral LeishmaniasisMicely d'El-Rei HermidaCaroline Vilas Boas de MeloIsadora dos Santos LimaGeraldo Gileno de Sá OliveiraWashington L. C. dos-SantosThe spleen is a secondary lymphoid organ responsible for immune surveillance against blood-circulating pathogens. Absence of the spleen is associated with increased susceptibility to systemic spread and fatal infection by different pathogens. Severe forms of visceral leishmaniasis are associated with disorganization of spleen compartments where cell interactions essential for splenic immunological function take place. White pulp atrophies, secondary lymphoid follicles and marginal zones vanish, and the boundaries separating white and red pulp blur. Leukocyte populations are reduced or disappear or are replaced by plasma cells. In this paper, we review the published data on spleen disorganization in severe forms of visceral leishmaniasis and propose a histological classification to help the exchange of information among research groups.https://www.frontiersin.org/article/10.3389/fcimb.2018.00394/fullvisceral leishmaniasiswhite pulp disruptionspleen disorganizationLeishmania infantumspleen pathology |
| spellingShingle | Micely d'El-Rei Hermida Caroline Vilas Boas de Melo Isadora dos Santos Lima Geraldo Gileno de Sá Oliveira Washington L. C. dos-Santos Histological Disorganization of Spleen Compartments and Severe Visceral Leishmaniasis Frontiers in Cellular and Infection Microbiology visceral leishmaniasis white pulp disruption spleen disorganization Leishmania infantum spleen pathology |
| title | Histological Disorganization of Spleen Compartments and Severe Visceral Leishmaniasis |
| title_full | Histological Disorganization of Spleen Compartments and Severe Visceral Leishmaniasis |
| title_fullStr | Histological Disorganization of Spleen Compartments and Severe Visceral Leishmaniasis |
| title_full_unstemmed | Histological Disorganization of Spleen Compartments and Severe Visceral Leishmaniasis |
| title_short | Histological Disorganization of Spleen Compartments and Severe Visceral Leishmaniasis |
| title_sort | histological disorganization of spleen compartments and severe visceral leishmaniasis |
| topic | visceral leishmaniasis white pulp disruption spleen disorganization Leishmania infantum spleen pathology |
| url | https://www.frontiersin.org/article/10.3389/fcimb.2018.00394/full |
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