The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes.
Myelin is essential for rapid saltatory conduction and is produced by Schwann cells in the peripheral nervous system and oligodendrocytes in the central nervous system. In both cell types the transcription factor Sox10 is an essential component of the myelin-specific regulatory network. Here we iden...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-10-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3814293?pdf=render |
| _version_ | 1811296280027070464 |
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| author | Julia Hornig Franziska Fröb Michael R Vogl Irm Hermans-Borgmeyer Ernst R Tamm Michael Wegner |
| author_facet | Julia Hornig Franziska Fröb Michael R Vogl Irm Hermans-Borgmeyer Ernst R Tamm Michael Wegner |
| author_sort | Julia Hornig |
| collection | DOAJ |
| description | Myelin is essential for rapid saltatory conduction and is produced by Schwann cells in the peripheral nervous system and oligodendrocytes in the central nervous system. In both cell types the transcription factor Sox10 is an essential component of the myelin-specific regulatory network. Here we identify Myrf as an oligodendrocyte-specific target of Sox10 and map a Sox10 responsive enhancer to an evolutionarily conserved element in intron 1 of the Myrf gene. Once induced, Myrf cooperates with Sox10 to implement the myelination program as evident from the physical interaction between both proteins and the synergistic activation of several myelin-specific genes. This is strongly reminiscent of the situation in Schwann cells where Sox10 first induces and then cooperates with Krox20 during myelination. Our analyses indicate that the regulatory network for myelination in oligodendrocytes is organized along similar general principles as the one in Schwann cells, but is differentially implemented. |
| first_indexed | 2024-04-13T05:46:15Z |
| format | Article |
| id | doaj.art-bdc94ced4883423eb2f33c834848cad9 |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-04-13T05:46:15Z |
| publishDate | 2013-10-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-bdc94ced4883423eb2f33c834848cad92022-12-22T02:59:57ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042013-10-01910e100390710.1371/journal.pgen.1003907The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes.Julia HornigFranziska FröbMichael R VoglIrm Hermans-BorgmeyerErnst R TammMichael WegnerMyelin is essential for rapid saltatory conduction and is produced by Schwann cells in the peripheral nervous system and oligodendrocytes in the central nervous system. In both cell types the transcription factor Sox10 is an essential component of the myelin-specific regulatory network. Here we identify Myrf as an oligodendrocyte-specific target of Sox10 and map a Sox10 responsive enhancer to an evolutionarily conserved element in intron 1 of the Myrf gene. Once induced, Myrf cooperates with Sox10 to implement the myelination program as evident from the physical interaction between both proteins and the synergistic activation of several myelin-specific genes. This is strongly reminiscent of the situation in Schwann cells where Sox10 first induces and then cooperates with Krox20 during myelination. Our analyses indicate that the regulatory network for myelination in oligodendrocytes is organized along similar general principles as the one in Schwann cells, but is differentially implemented.http://europepmc.org/articles/PMC3814293?pdf=render |
| spellingShingle | Julia Hornig Franziska Fröb Michael R Vogl Irm Hermans-Borgmeyer Ernst R Tamm Michael Wegner The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes. PLoS Genetics |
| title | The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes. |
| title_full | The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes. |
| title_fullStr | The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes. |
| title_full_unstemmed | The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes. |
| title_short | The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes. |
| title_sort | transcription factors sox10 and myrf define an essential regulatory network module in differentiating oligodendrocytes |
| url | http://europepmc.org/articles/PMC3814293?pdf=render |
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