Phellinus igniarius ameliorates renal aging in a rat model of focal and segmental glomerulosclerosis
Objective: To comparatively investigate the ameliorative effect of Phellinus igniarius (P. igniarius) on renal aging in a rat model of focal and segmental glomerulosclerosis (FSGS). Methods: The FSGS model was established in rats by uninephrectomy combined with tail vein injection of doxorubicin. Th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Asian Pacific Journal of Tropical Biomedicine |
| Subjects: | |
| Online Access: | http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=8;spage=359;epage=368;aulast=Wang |
| _version_ | 1827242851715514368 |
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| author | Zhou-Ting Wang Yue-Wen Tang Feng Wan Ru-Chun Yang Yan Guo Jie Zheng You-Gui Li Wei-Ming He |
| author_facet | Zhou-Ting Wang Yue-Wen Tang Feng Wan Ru-Chun Yang Yan Guo Jie Zheng You-Gui Li Wei-Ming He |
| author_sort | Zhou-Ting Wang |
| collection | DOAJ |
| description | Objective: To comparatively investigate the ameliorative effect of Phellinus igniarius (P. igniarius) on renal aging in a rat model of focal and segmental glomerulosclerosis (FSGS).
Methods: The FSGS model was established in rats by uninephrectomy combined with tail vein injection of doxorubicin. The FSGS rats were randomly divided into the model group, the P. igniarius decoction group, the P. igniarius polysaccharides group, and the P. igniarius polyphenols group. Molecular indicators of cell senescence, renal function indexes, and podocyte injury markers were tested after ten weeks of intragastric administration. Besides, the pathological renal lesions and the ultrastructural changes were observed.
Results: FSGS developed in the model group within ten weeks and showed segmental glomerular scarring and renal aging. Following the 10-week intervention, 24 h proteinuria, serum creatinine, blood urea nitrogen, P16INK4α, thrombospondin-1, and transforming growth factor-β1 were decreased in each treatment group, whereas albumin, erythropoietin, nephrin, and podocin were increased; the pathological renal injury was alleviated, and the number of senescent cells was reduced, especially in rats treated with P. igniarius decoction.
Conclusions: P. igniarius ameliorates renal aging and renal injury in the FSGS rat model. Compared with the effective constituents (polysaccharides and polyphenols), P. igniarius decoction has a better curative effect, which is expected to provide a new therapeutic idea for FSGS. |
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| format | Article |
| id | doaj.art-bdc9f47049b04099826f95d010795cc9 |
| institution | Directory Open Access Journal |
| issn | 2221-1691 2588-9222 |
| language | English |
| last_indexed | 2025-03-21T22:02:57Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Biomedicine |
| spelling | doaj.art-bdc9f47049b04099826f95d010795cc92024-05-25T11:46:22ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912588-92222023-01-0113835936810.4103/2221-1691.383690Phellinus igniarius ameliorates renal aging in a rat model of focal and segmental glomerulosclerosisZhou-Ting WangYue-Wen TangFeng WanRu-Chun YangYan GuoJie ZhengYou-Gui LiWei-Ming HeObjective: To comparatively investigate the ameliorative effect of Phellinus igniarius (P. igniarius) on renal aging in a rat model of focal and segmental glomerulosclerosis (FSGS). Methods: The FSGS model was established in rats by uninephrectomy combined with tail vein injection of doxorubicin. The FSGS rats were randomly divided into the model group, the P. igniarius decoction group, the P. igniarius polysaccharides group, and the P. igniarius polyphenols group. Molecular indicators of cell senescence, renal function indexes, and podocyte injury markers were tested after ten weeks of intragastric administration. Besides, the pathological renal lesions and the ultrastructural changes were observed. Results: FSGS developed in the model group within ten weeks and showed segmental glomerular scarring and renal aging. Following the 10-week intervention, 24 h proteinuria, serum creatinine, blood urea nitrogen, P16INK4α, thrombospondin-1, and transforming growth factor-β1 were decreased in each treatment group, whereas albumin, erythropoietin, nephrin, and podocin were increased; the pathological renal injury was alleviated, and the number of senescent cells was reduced, especially in rats treated with P. igniarius decoction. Conclusions: P. igniarius ameliorates renal aging and renal injury in the FSGS rat model. Compared with the effective constituents (polysaccharides and polyphenols), P. igniarius decoction has a better curative effect, which is expected to provide a new therapeutic idea for FSGS.http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=8;spage=359;epage=368;aulast=Wangphellinus igniarius; polysaccharides; polyphenols; fsgs; renal aging; rat; renal injury |
| spellingShingle | Zhou-Ting Wang Yue-Wen Tang Feng Wan Ru-Chun Yang Yan Guo Jie Zheng You-Gui Li Wei-Ming He Phellinus igniarius ameliorates renal aging in a rat model of focal and segmental glomerulosclerosis Asian Pacific Journal of Tropical Biomedicine phellinus igniarius; polysaccharides; polyphenols; fsgs; renal aging; rat; renal injury |
| title | Phellinus igniarius ameliorates renal aging in a rat model of focal and segmental glomerulosclerosis |
| title_full | Phellinus igniarius ameliorates renal aging in a rat model of focal and segmental glomerulosclerosis |
| title_fullStr | Phellinus igniarius ameliorates renal aging in a rat model of focal and segmental glomerulosclerosis |
| title_full_unstemmed | Phellinus igniarius ameliorates renal aging in a rat model of focal and segmental glomerulosclerosis |
| title_short | Phellinus igniarius ameliorates renal aging in a rat model of focal and segmental glomerulosclerosis |
| title_sort | phellinus igniarius ameliorates renal aging in a rat model of focal and segmental glomerulosclerosis |
| topic | phellinus igniarius; polysaccharides; polyphenols; fsgs; renal aging; rat; renal injury |
| url | http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=8;spage=359;epage=368;aulast=Wang |
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