Diagnostic accuracy of 99mTc-antigranulocyte SPECT/CT in patients with osteomyelitis and orthopaedic device-related infections: A retrospective analysis
Objectives: Conventional imaging techniques are routinely used in the diagnostic work-up of patients with suspected osteomyelitis or orthopaedic implant-associated infections. Hybrid nuclear medicine imaging techniques are a suitable alternative to routine imaging modalities as they provide anatomic...
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| Format: | Article |
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Elsevier
2020-02-01
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| Series: | International Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971219304564 |
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| author | A. Plate V. Weichselbaumer R. Schüpbach S.F. Fucentese M. Berli M. Hüllner Y. Achermann |
| author_facet | A. Plate V. Weichselbaumer R. Schüpbach S.F. Fucentese M. Berli M. Hüllner Y. Achermann |
| author_sort | A. Plate |
| collection | DOAJ |
| description | Objectives: Conventional imaging techniques are routinely used in the diagnostic work-up of patients with suspected osteomyelitis or orthopaedic implant-associated infections. Hybrid nuclear medicine imaging techniques are a suitable alternative to routine imaging modalities as they provide anatomical and functional information within one procedure. Our study investigated the performance of anti-granulocyte SPECT/CT using 99mTc-labelled monoclonal antibodies in the diagnosis of osteomyelitis and orthopaedic implant-associated infections. Methods: In this retrospective analysis, we included patients with 99mTc-antigranulocyte SPECT/CT acquired in the context of a suspected bone and joint infection. All patients underwent routine diagnostics and/or had a clinical follow-up of at least 12 months. Results: 26 episodes were included. Fifteen exams were performed for suspected osteomyelitis, and 11 for suspected orthopaedic implant-associated infection. SPECT/CT was ordered most often if standard diagnostic tests or conventional imaging modalities remained inconclusive. The overall sensitivity and specificity for the diagnosis of an infection were 77.8% and 94.1%, respectively. The positive predictive value was 87.5% and the negative predictive value 88.9%. Diagnostic accuracy was 88.5%. Conclusions: 99mTc-antigranulocyte SPECT/CT imaging has a high accuracy in the diagnosis of osteomyelitis and orthopaedic implant-associated infections and is a suitable non-invasive diagnostic tool if standard diagnostic examinations are inconclusive or not applicable. Keywords: Periprosthetic joint infection (PJI), Osteosynthesis associated infections (OAI), Osteomyelitis, 99mTc-antigranulocyte SPECT/CT, Monoclonal antibody, Diagnosis |
| first_indexed | 2024-12-12T00:57:58Z |
| format | Article |
| id | doaj.art-bdcd78b3c73b42df87ebb08efac90538 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-12T00:57:58Z |
| publishDate | 2020-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-bdcd78b3c73b42df87ebb08efac905382022-12-22T00:43:49ZengElsevierInternational Journal of Infectious Diseases1201-97122020-02-01917986Diagnostic accuracy of 99mTc-antigranulocyte SPECT/CT in patients with osteomyelitis and orthopaedic device-related infections: A retrospective analysisA. Plate0V. Weichselbaumer1R. Schüpbach2S.F. Fucentese3M. Berli4M. Hüllner5Y. Achermann6Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Rämistrasse 100, Zurich, 8091, Switzerland; Corresponding author.Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Rämistrasse 100, Zurich, 8091, SwitzerlandDepartment of Orthopaedics, University Hospital Balgrist, University of Zurich, Forchstrasse 340, Zurich, 8008 SwitzerlandDepartment of Orthopaedics, University Hospital Balgrist, University of Zurich, Forchstrasse 340, Zurich, 8008 SwitzerlandDepartment of Orthopaedics, University Hospital Balgrist, University of Zurich, Forchstrasse 340, Zurich, 8008 SwitzerlandDepartment of Nuclear Medicine, University Hospital Zurich, University of Zurich, Rämistrasse 100, Zurich, 8091, SwitzerlandDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Rämistrasse 100, Zurich, 8091, SwitzerlandObjectives: Conventional imaging techniques are routinely used in the diagnostic work-up of patients with suspected osteomyelitis or orthopaedic implant-associated infections. Hybrid nuclear medicine imaging techniques are a suitable alternative to routine imaging modalities as they provide anatomical and functional information within one procedure. Our study investigated the performance of anti-granulocyte SPECT/CT using 99mTc-labelled monoclonal antibodies in the diagnosis of osteomyelitis and orthopaedic implant-associated infections. Methods: In this retrospective analysis, we included patients with 99mTc-antigranulocyte SPECT/CT acquired in the context of a suspected bone and joint infection. All patients underwent routine diagnostics and/or had a clinical follow-up of at least 12 months. Results: 26 episodes were included. Fifteen exams were performed for suspected osteomyelitis, and 11 for suspected orthopaedic implant-associated infection. SPECT/CT was ordered most often if standard diagnostic tests or conventional imaging modalities remained inconclusive. The overall sensitivity and specificity for the diagnosis of an infection were 77.8% and 94.1%, respectively. The positive predictive value was 87.5% and the negative predictive value 88.9%. Diagnostic accuracy was 88.5%. Conclusions: 99mTc-antigranulocyte SPECT/CT imaging has a high accuracy in the diagnosis of osteomyelitis and orthopaedic implant-associated infections and is a suitable non-invasive diagnostic tool if standard diagnostic examinations are inconclusive or not applicable. Keywords: Periprosthetic joint infection (PJI), Osteosynthesis associated infections (OAI), Osteomyelitis, 99mTc-antigranulocyte SPECT/CT, Monoclonal antibody, Diagnosishttp://www.sciencedirect.com/science/article/pii/S1201971219304564 |
| spellingShingle | A. Plate V. Weichselbaumer R. Schüpbach S.F. Fucentese M. Berli M. Hüllner Y. Achermann Diagnostic accuracy of 99mTc-antigranulocyte SPECT/CT in patients with osteomyelitis and orthopaedic device-related infections: A retrospective analysis International Journal of Infectious Diseases |
| title | Diagnostic accuracy of 99mTc-antigranulocyte SPECT/CT in patients with osteomyelitis and orthopaedic device-related infections: A retrospective analysis |
| title_full | Diagnostic accuracy of 99mTc-antigranulocyte SPECT/CT in patients with osteomyelitis and orthopaedic device-related infections: A retrospective analysis |
| title_fullStr | Diagnostic accuracy of 99mTc-antigranulocyte SPECT/CT in patients with osteomyelitis and orthopaedic device-related infections: A retrospective analysis |
| title_full_unstemmed | Diagnostic accuracy of 99mTc-antigranulocyte SPECT/CT in patients with osteomyelitis and orthopaedic device-related infections: A retrospective analysis |
| title_short | Diagnostic accuracy of 99mTc-antigranulocyte SPECT/CT in patients with osteomyelitis and orthopaedic device-related infections: A retrospective analysis |
| title_sort | diagnostic accuracy of 99mtc antigranulocyte spect ct in patients with osteomyelitis and orthopaedic device related infections a retrospective analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1201971219304564 |
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