Nintedanib and Dasatinib Treatments Induce Protective Autophagy as a Potential Resistance Mechanism in MPM Cells

Nintedanib and Dasatinib Treatments Induce Protective Autophagy as a Potential Resistance Mechanism in MPM Cells

Malignant pleural mesothelioma (MPM) is a rare type of cancer with a grim prognosis. So far, no targetable oncogenic mutation was identified in MPM and biomarkers with predictive value toward drug sensitivity or resistance are also lacking. Nintedanib (BIBF1120) is a small-molecule tyrosine kinase i...

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Bibliographic Details
Main Authors: Luca Hegedüs, Kata D. Szücs, Matthias Kudla, Julian Heidenreich, Verena Jendrossek, Samuel Peña-Llopis, Tamas Garay, Andras Czirok, Clemens Aigner, Till Plönes, Silvia Vega-Rubin-de-Celis, Balazs Hegedüs
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
malignant pleural mesothelioma
autophagy
TFEB
nintedanib
dasatinib
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.852812/full

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