CRISPR/Cas9: the Jedi against the dark empire of diseases
Abstract Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes. The scientific community is using CRISPR/Cas9 for various biotechnological and medical purposes. One of its most important uses...
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| Format: | Article |
| Language: | English |
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BMC
2018-03-01
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| Series: | Journal of Biomedical Science |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12929-018-0425-5 |
| _version_ | 1811330601139044352 |
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| author | Sehrish Khan Muhammad Shahid Mahmood Sajjad ur Rahman Hassan Zafar Sultan Habibullah Zulqarnain khan Aftab Ahmad |
| author_facet | Sehrish Khan Muhammad Shahid Mahmood Sajjad ur Rahman Hassan Zafar Sultan Habibullah Zulqarnain khan Aftab Ahmad |
| author_sort | Sehrish Khan |
| collection | DOAJ |
| description | Abstract Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes. The scientific community is using CRISPR/Cas9 for various biotechnological and medical purposes. One of its most important uses is developing potential therapeutic strategies against diseases. CRISPR/Cas9 based approaches have been increasingly applied to the treatment of human diseases like cancer, genetic, immunological and neurological disorders and viral diseases. These strategies using CRISPR/Cas9 are not only therapy oriented but can also be used for disease modeling as well, which in turn can lead to the improved understanding of mechanisms of various infectious and genetic diseases. In addition, CRISPR/Cas9 system can also be used as programmable antibiotics to kill the bacteria sequence specifically and therefore can bypass multidrug resistance. Furthermore, CRISPR/Cas9 based gene drive may also hold the potential to limit the spread of vector borne diseases. This bacterial and archaeal adaptive immune system might be a therapeutic answer to previous incurable diseases, of course rigorous testing is required to corroborate these claims. In this review, we provide an insight about the recent developments using CRISPR/Cas9 against various diseases with respect to disease modeling and treatment, and what future perspectives should be noted while using this technology. |
| first_indexed | 2024-04-13T16:04:47Z |
| format | Article |
| id | doaj.art-bdd1ccb3b0494fedad8cbc4b41c835e2 |
| institution | Directory Open Access Journal |
| issn | 1423-0127 |
| language | English |
| last_indexed | 2024-04-13T16:04:47Z |
| publishDate | 2018-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj.art-bdd1ccb3b0494fedad8cbc4b41c835e22022-12-22T02:40:25ZengBMCJournal of Biomedical Science1423-01272018-03-0125111810.1186/s12929-018-0425-5CRISPR/Cas9: the Jedi against the dark empire of diseasesSehrish Khan0Muhammad Shahid Mahmood1Sajjad ur Rahman2Hassan Zafar3Sultan Habibullah4Zulqarnain khan5Aftab Ahmad6Institute of Microbiology University of AgricultureInstitute of Microbiology University of AgricultureInstitute of Microbiology University of AgricultureInstitute of Microbiology University of AgricultureCenter of Agricultural Biochemistry and Biotechnology, University of AgricultureCenter of Agricultural Biochemistry and Biotechnology, University of AgricultureDepartment of Biochemistry/U.S.-Pakistan Center for Advanced Studies in Agriculture and Food Security (USPCAS-AFS), University of Agriculture Faisalabad (UAF)Abstract Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes. The scientific community is using CRISPR/Cas9 for various biotechnological and medical purposes. One of its most important uses is developing potential therapeutic strategies against diseases. CRISPR/Cas9 based approaches have been increasingly applied to the treatment of human diseases like cancer, genetic, immunological and neurological disorders and viral diseases. These strategies using CRISPR/Cas9 are not only therapy oriented but can also be used for disease modeling as well, which in turn can lead to the improved understanding of mechanisms of various infectious and genetic diseases. In addition, CRISPR/Cas9 system can also be used as programmable antibiotics to kill the bacteria sequence specifically and therefore can bypass multidrug resistance. Furthermore, CRISPR/Cas9 based gene drive may also hold the potential to limit the spread of vector borne diseases. This bacterial and archaeal adaptive immune system might be a therapeutic answer to previous incurable diseases, of course rigorous testing is required to corroborate these claims. In this review, we provide an insight about the recent developments using CRISPR/Cas9 against various diseases with respect to disease modeling and treatment, and what future perspectives should be noted while using this technology.http://link.springer.com/article/10.1186/s12929-018-0425-5CRISPR/Cas9Disease modelingGenetic diseases |
| spellingShingle | Sehrish Khan Muhammad Shahid Mahmood Sajjad ur Rahman Hassan Zafar Sultan Habibullah Zulqarnain khan Aftab Ahmad CRISPR/Cas9: the Jedi against the dark empire of diseases Journal of Biomedical Science CRISPR/Cas9 Disease modeling Genetic diseases |
| title | CRISPR/Cas9: the Jedi against the dark empire of diseases |
| title_full | CRISPR/Cas9: the Jedi against the dark empire of diseases |
| title_fullStr | CRISPR/Cas9: the Jedi against the dark empire of diseases |
| title_full_unstemmed | CRISPR/Cas9: the Jedi against the dark empire of diseases |
| title_short | CRISPR/Cas9: the Jedi against the dark empire of diseases |
| title_sort | crispr cas9 the jedi against the dark empire of diseases |
| topic | CRISPR/Cas9 Disease modeling Genetic diseases |
| url | http://link.springer.com/article/10.1186/s12929-018-0425-5 |
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