Click Chemistry in Natural Product Modification
Click chemistry is perhaps the most powerful synthetic toolbox that can efficiently access the molecular diversity and unique functions of complex natural products up to now. It enables the ready synthesis of diverse sets of natural product derivatives either for the optimization of their drawbacks...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2021.774977/full |
| _version_ | 1818750792493957120 |
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| author | Xiang Zhang Shuning Zhang Songfeng Zhao Xuan Wang Bo Liu Hongtao Xu |
| author_facet | Xiang Zhang Shuning Zhang Songfeng Zhao Xuan Wang Bo Liu Hongtao Xu |
| author_sort | Xiang Zhang |
| collection | DOAJ |
| description | Click chemistry is perhaps the most powerful synthetic toolbox that can efficiently access the molecular diversity and unique functions of complex natural products up to now. It enables the ready synthesis of diverse sets of natural product derivatives either for the optimization of their drawbacks or for the construction of natural product-like drug screening libraries. This paper showcases the state-of-the-art development of click chemistry in natural product modification and summarizes the pharmacological activities of the active derivatives as well as the mechanism of action. The aim of this paper is to gain a deep understanding of the fruitful achievements and to provide perspectives, trends, and directions regarding further research in natural product medicinal chemistry. |
| first_indexed | 2024-12-18T04:25:18Z |
| format | Article |
| id | doaj.art-bdd32c1de0a84da0ac7d7a280a820b0c |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-18T04:25:18Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-bdd32c1de0a84da0ac7d7a280a820b0c2022-12-21T21:21:08ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-11-01910.3389/fchem.2021.774977774977Click Chemistry in Natural Product ModificationXiang Zhang0Shuning Zhang1Songfeng Zhao2Xuan Wang3Bo Liu4Hongtao Xu5Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, ChinaThe Second Clinical Medical College, Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Second Clinical Medical College, Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, ChinaShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, ChinaClick chemistry is perhaps the most powerful synthetic toolbox that can efficiently access the molecular diversity and unique functions of complex natural products up to now. It enables the ready synthesis of diverse sets of natural product derivatives either for the optimization of their drawbacks or for the construction of natural product-like drug screening libraries. This paper showcases the state-of-the-art development of click chemistry in natural product modification and summarizes the pharmacological activities of the active derivatives as well as the mechanism of action. The aim of this paper is to gain a deep understanding of the fruitful achievements and to provide perspectives, trends, and directions regarding further research in natural product medicinal chemistry.https://www.frontiersin.org/articles/10.3389/fchem.2021.774977/fullnatural productclick chemistrydrug discoverymodular synthesistriazolesulfur(VI) fluoride exchange |
| spellingShingle | Xiang Zhang Shuning Zhang Songfeng Zhao Xuan Wang Bo Liu Hongtao Xu Click Chemistry in Natural Product Modification Frontiers in Chemistry natural product click chemistry drug discovery modular synthesis triazole sulfur(VI) fluoride exchange |
| title | Click Chemistry in Natural Product Modification |
| title_full | Click Chemistry in Natural Product Modification |
| title_fullStr | Click Chemistry in Natural Product Modification |
| title_full_unstemmed | Click Chemistry in Natural Product Modification |
| title_short | Click Chemistry in Natural Product Modification |
| title_sort | click chemistry in natural product modification |
| topic | natural product click chemistry drug discovery modular synthesis triazole sulfur(VI) fluoride exchange |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2021.774977/full |
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