The SWI/SNF ATPase BRG1 facilitates multiple pro-tumorigenic gene expression programs in SMARCB1-deficient cancer cells

The SWI/SNF ATPase BRG1 facilitates multiple pro-tumorigenic gene expression programs in SMARCB1-deficient cancer cells

Abstract Malignant rhabdoid tumor (MRT) is driven by the loss of the SNF5 subunit of the SWI/SNF chromatin remodeling complex and then thought to be maintained by residual SWI/SNF (rSWI/SNF) complexes that remain present in the absence of SNF5. rSWI/SNF subunits colocalize extensively on chromatin w...

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Bibliographic Details
Main Authors: Kylie C. Moe, Jack N. Maxwell, Jing Wang, Cheyenne A. Jones, Grace T. Csaki, Andrea C. Florian, Alexander S. Romer, Daniel L. Bryant, Anthony L. Farone, Qi Liu, William P. Tansey, April M. Weissmiller
Format: Article
Language:English
Published: Nature Publishing Group 2022-06-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-022-00406-6

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